Volume 81, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Although we have encountered many cases of monoclonal gammopathies (MGs) or oligoclonal gammopathies (OGs) in patients with infections, the clinical course of MG/OG associated with these infections has rarely been reported. We serially monitored 18 cases of MG/OG that appeared in the acute phase or early convalescent phase of scrub typhus. All MGs/OGs associated with infection with disappeared 7–15 weeks after treatment with doxycycline. In three cases of scrub typhus, MGs/OGs appeared before seropositive conversion (presence of antibodies against ) and disappeared before seronegative conversion. Understanding our cases may be helpful for relevant clinical counseling and making appropriate medical decisions to avoid unnecessary invasive or cost-intensive diagnostic procedures for MGs/OGs in scrub typhus, especially in disease-endemic areas. We also suggest that 2–4 months after antibiotic treatment might be the optimal follow-up time to observe the disappearance of MGs/OGs associated with infections.


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  • Received : 31 Jan 2009
  • Accepted : 05 Jul 2009

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