Volume 81, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Particular alleles of the gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the -511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of and recurrence rate after treatment, -511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust eradication efforts in Peru.


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  • Received : 24 Sep 2008
  • Accepted : 14 Jul 2009

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