1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 79, Issue 6
  4. Article
Volume 79, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

A Phase 1 study of the apical membrane antigen malaria vaccine AMA1-C1/Alhydrogel was conducted in 2–3-year-old children in a village in Mali. A high frequency of elevated levels of alanine aminotransferase (ALT) caused by hepatitis A was seen, with 8 of 36 children diagnosed by specific IgM antibody over the course of the study. Hepatitis A is a common cause of asymptomatic elevations of ALT levels in children, particularly in less-developed settings. Investigators should be aware of the frequency of hepatitis A in this age group to guard against inadvertently facilitating transmission at study facilities and to properly evaluate symptomatic or asymptomatic elevations of ALT levels.

Copyright 2008 The American Society of Tropical Medicine
Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2008.79.980
2008-12-01
2018-10-21

  • From This Site

    /content/journals/10.4269/ajtmh.2008.79.980
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/79/6/0790980.html?itemId=/content/journals/10.4269/ajtmh.2008.79.980&mimeType=html&fmt=ahah

References

  1. Dicko A, Sagara I, Ellis RD, Miura K, Guindo O, Kamate B, Sogoba M, Niambelé MB, Sissoko M, Baby M, Dolo A, Mullen GED, Fay MP, 2008. Pierce, Diallo DA, Saul A, Miller LH, Doumbo OK. Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children, 2008. PLoS ONE 3 : e1563.
  2. Bell BP, 2002. Global epidemiology of hepatitis A: implications for control strategies. Margolis HS, Alter MJ, Liang TJ, Dienstag JL, eds. Viral Hepatitis and Liver Disease. London: International Medical Press, 9–14.
  3. Ajdukiewicz A, Mosley JW, 1980. Hepatitis A antibody in West Africa. Lancet 2 : 695.
  4. Barin F, Denis F, Chotard J, Paulin R, Chiron JP, Maupas PH, Goudeau A, Coursaget P, 1980. Early asymptomatic hepatitis A in Senegalese children. Lancet 1 : 212–213.
  5. Hodges M, Sanders E, Aitken C, 1998. Seroprevalence of hepatitis markers: HAV, HBC, HCV, and HEV amongst primary school children in Freetown, Sierra Leone. West Afr J Med 17 : 36–37.
  6. Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP), 1999. MMWR Morb Mortal Wkly Rep 48 (RR-12): 1–37.
  7. Macete E, Aponte JJ, Guiinovart C, Sacarlal J, Ofori-Anyinam O, Mandomando I, Espasa M, Bevilacqua C, Leach A, Dubois MC, Heppner DG, Tello L, Milman J, Cohen J, Dubovsky F, Tornieporth N, Thompson R, Alonso PL, 2007. Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique. Trop Med Int Health 12 : 37–46.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2008.79.980
Loading
Elevated Levels of Alanine Aminotransferase and Hepatitis A in the Context of a Pediatric Malaria Vaccine Trial in a Village in Mali
The American Journal of Tropical Medicine and Hygiene 79, 980 (2008); https://doi.org/10.4269/ajtmh.2008.79.980
/content/journals/10.4269/ajtmh.2008.79.980
/content/journals/10.4269/ajtmh.2008.79.980
Loading

Data & Media loading...

  • Received : 19 May 2008
  • Accepted : 30 Jul 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error