1921
Volume 79, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

This population-based cross-sectional study of 403 rural settlers in Brazilian Amazonia revealed an overall rate of IgG seropositivity to excretory-secretory larval antigen of 26.8% (95% confidence interval [CI], 22.5–31.4%). Multilevel logistic regression analysis identified current infection with hookworm (odds ratio [OR], 2.32; 95% CI, 1.11–4.86) and residence in the most recently occupied sectors of the settlement (OR, 1.81; 95%CI, 1.3–2.52) as significant risk factors for seropositivity; age > 14 years (OR, 0.46; 95% CI, 0.28–0.73) and the presence of cats in the household (OR, 0.57; 95% CI, 0.32–1.02) appeared to be protective. Two significant high-prevalence clusters were detected in the area, together comprising 38.9% of the seropositive subjects; households in the clusters had slightly lower socioeconomic status and were less likely to have cats as pets. The obstacles for controlling human toxocariasis in this and other tropical rural settings are discussed.

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2008-07-01
2017-09-20
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References

  1. Wilder HC, 1950. Nematode endophthalmitis. Trans Am Acad Ophthalmol Otolaryngol 55 : 99–109.
  2. Beaver PC, Snyder CH, Carrera GM, 1952. Chronic eosinophilia due to visceral larva migrans. Pediatrics 9 : 7–19.
  3. Pawlowski Z, 2001. Toxocariasis in humans: clinical expression and treatment dilemma. J Helminthol 75 : 299–305.
  4. Despommier D, 2003. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev 16 : 265–272.
  5. Magnaval JF, Glickman LT, Dorchies P, Morassin B, 2001. Highlights of human toxocariasis. Korean J Parasitol 39 : 1–11.
  6. Baboolal S, Rawlins SC, 2002. Seroprevalence of toxocariasis in schoolchildren in Trinidad. Trans R Soc Trop Med Hyg 96 : 139–143.
  7. Fan CK, Hung CC, Du WY, Liao CW, Su KE, 2004. Seroepidemiology of Toxocara canis infection among mountain aboriginal schoolchildren living in contaminated districts in eastern Taiwan. Trop Med Int Health 9 : 1312–1318.
  8. Hayashi E, Tuda J, Imada M, Akao N, Fujita K, 2005. The high prevalence of asymptomatic Toxocara infection among schoolchildren in Manado, Indonesia. Southeast J Trop Med Public Health 36 : 1399–1406.
  9. Paquet-Durand I, Hernández J, Dolz G, Zuñiga JJR, Schneider T, Epe C, 2007. Prevalence of Toxocara spp., Toxacaris leonina and ancylostomidae in public parks and beaches in different climate zones of Costa Rica. Acta Trop 104 : 30–37.
  10. Capuano DM, Rocha G de M, 2005. Environmental contamination by Toxocara sp. eggs in Ribeirão Preto, São Paulo State, Brazil. Rev Inst Med Trop Sao Paulo 47 : 223–226.
  11. Chiodo P, Basualdo J, Ciarmela L, Pezzani B, Apezteguía M, Minvielle M, 2006. Related factors to human toxocariasis in a rural community of Argentina. Mem Inst Oswaldo Cruz 101 : 397–400.
  12. Moreira-Silva SF, Leão ME, Mendonça HFS, Pereira FEL, 1998. Prevalence of anti-Toxocara antibodies in a random sample of inpatients at a children’s hospital in Vitória, Espírito Santo, Brazil. Rev Inst Med Trop Sao Paulo 40 : 259–261.
  13. Alderete JMS, Jacob CMA, Pastorino AC, Elefant GR, Castro APM, Fomin ABF, Chieffi PP, 2003. Prevalence of Toxocara infection in schoolchildren from the Butantã region, São Paulo, Brazil. Mem Inst Oswaldo Cruz 98 : 593–597.
  14. Anaruma FF, Chieffi PP, Correa CR, Camargo ED, da Silveira EP, Aranha JJ, 2003. Human toxocariasis: incidence among residents in the outskirts of Campinas, State of São Paulo, Brazil. Rev Inst Med Trop Sao Paulo 45 : 293–294.
  15. Campos D Jr, Elefant GR, de Melo e Silva EO, Gandolfi L, Jacob CMA, Tofeti A, Pratesi R, 2003. Frequency of seropositivity to Toxocara canis in children of different socioeconomic strata. Rev Soc Bras Med Trop 36 : 509–513.
  16. Coelho RAL, Carvalho LB Jr, Perez EP, Araki K, Takeuchi T, Ito A, Aoki T, Yamasaki H, 2005. Prevalence of toxocariasis in Northeastern Brazil based on serology using recombinant Toxocara canis antigen. Am J Trop Med Hyg 72 : 103–107.
  17. Teixeira CR, Chieffi PP, Lescano AS, de Melo Silva EO, Fux B, Cury MC, 2006. Frequency and risk factors for toxocariasis in children from a pediatric outpatient center in southeastern Brazil. Rev Inst Med Trop Sao Paulo 48 : 251–255.
  18. Ferreira MU, Rubinsky-Elefant G, Castro TG, Hoffmann EHE, da Silva-Nunes M, Cardoso MA, Muniz PT, 2007. Bottle feeding and exposure to Toxocara as risk factors for wheezing illness among under-five Amazonian children: a population-based cross-sectional survey. J Trop Pediatr 53 : 119–124.
  19. Anaruma Filho F, Chieffi PP, Correa CR, Camargo ED, Silveira EP, Aranha JJ, Ribeiro MC, 2002. Human toxocariasis: a seroepidemiological survey in the municipality of Campinas (SP), Brazil. Rev Inst Med Trop S Paulo 44 : 303–307.
  20. Souza EA, da Silva-Nunes M, Malafronte RS, Muniz PT, Cardoso MA, Ferreira MU, 2007. Prevalence and intestinal distribution of intestinal parasitic infections in a rural Amazonian settlement, Acre State, Brazil. Cad Saude Publica 23 : 427–434.
  21. Filmer D, Pritchett LH, 2001. Estimating wealth effects without expenditure data-or tear: an application to educational enrolments in states of India. Demography 38 : 115–132.
  22. Elefant GR, Shimizu SH, Sanchez MCA, Jacob CMA, Ferreira AW, 2006. A serological follow-up of toxocariasis patients after chemotherapy based on the detection of IgG, IgA and IgE antibodies by enzyme-linked immunosorbent assay. J Clin Lab Anal 20 : 164–172.
  23. Kennedy MW, Maizels RM, Meghji M, Young L, Qureshi F, Smith HV, 1987. Species-specific and common epitopes on the secreted and surface antigens of Toxocara canis and Toxocara cati infective larvae. Parasite Immunol 9 : 407–420.
  24. Romasanta A, Romero JL, Arias M, Sánchez-Andrade R, López C, Suárez JL, Días P, Díez-Baños P, Morrondo P, Paz-Silva A, 2003. Diagnosis of parasitic zoonosis by immunoenzymatic assays—analysis of cross-reactivity among the excretory/secretory antigens of Fasciola hepatica, Toxocara canis, and Ascaris suum. Immunol Invest 32 : 131–142.
  25. Gyorkos TW, McLean JD, Law CG, 1989. Absence of significant differences in intestinal parasite prevalence estimates after examination of either one or two stool specimens. Am J Epidemiol 130 : 976–980.
  26. Kulldorff M, Nagarwalla N, 1995. Spatial disease clusters: detection and inference. Stat Med 14 : 799–819.
  27. Holland CV, O’Lorcain P, Taylor MR, Kelly A, 1995. Seroepidemiology of toxocariasis in school children. Parasitology 110 : 535–545.
  28. Rai SK, Uga S, Ono K, Nakanishi M, Shrestha HG, Matsumura T, 1996. Seroepidemiological study of Toxocara infection in Nepal. Southeast J Trop Med Public Health 27 : 286–290.
  29. Alonso JM, Bojanich MV, Chamorro M, Gorodner JO, 2000. Toxocara seroprevalence in children from a subtropical city in Argentina. Rev Inst Med Trop S Paulo 42 : 235–237.
  30. Kanafani ZA, Skoury A, Araj GF, El-Khoury M, Sawaya RA, Atweh SF, Kanj SS, 2006. Seroprevalence of toxocariasis in Lebanon: a pilot survey. Parasitology 132 : 635–639.
  31. Magnaval J, Baixench M, 1993. Toxocariasis in the Midi Pyrenées region. In JW Lewis, RM Maizels (eds). Toxocara and Toxocariasis. British Society for Parasitology, London, pp. 63–69.
  32. Glickman LT, Schantz PM, Cypess RH, 1979. Epidemiological characteristics and clinical findings in patients with serologically proven toxocariasis. Trans R Soc Trop Med Hyg 73 : 254–258.
  33. Jiménez JF, Valladares B, Fernández-Palacios JM, de Armas F, del Castillo A, 1997. A serological study of human toxocariasis in the Canary Islands (Spain): environmental influences. Am J Trop Med Hyg 56 : 113–115.
  34. Sadjjadi SM, Khosravi M, Mehrabani D, Orya A, 2000. Seroprevalence of Toxocara infection in school children in Shiraz, southern Iran. J Trop Pediatr 46 : 327–330.
  35. Fan CK, Lan HS, Hung CC, Chung WC, Liao CW, Du WY, Su KE, 2004. Seroepidemiology of Toxocara canis infection among mountain aboriginal adults in Taiwan. Am J Trop Med Hyg 71 : 216–221.
  36. Herrmann N, Glickman LT, Schantz PM, Weston MG, Domanski LM, 1985. Seroprevalence of zoonotic toxocariasis in the United States: 1971–1973. Am J Epidemiol 122 : 890–896.
  37. González-Quintella A, Gude F, Campos J, Garea MT, Romero PA, Rey J, Meijide LM, Fernández-Merino MC, Vidal C, 2006. Toxocara infection seroprevalence and its relationship with atopic features in a general adult population. Int Arch Allergy Immunol 139 : 317–324.
  38. Marmor M, Glickman LT, Shofer F, Faich LA, Rosenberg C, Cornblatt B, Friedman S, 1987. Toxocara infection in children: epidemiologic and neuropsychologic findings. Am J Public Health 77 : 554–559.
  39. Fan CK, Liao CW, Kao TC, Li MH, Du WY, Su KE, 2005. Seroepidemiology of Toxocara canis infection among aboriginal schoolchildren in the mountainous areas of north-eastern Taiwan. Ann Trop Med Parasitol 99 : 593–600.
  40. Ajayi OO, Duhlinka DD, Agwale SM, Njoku M, 2000. Frequency of human toxocariasis in Jos, Plateau state, Nigeria. Mem Inst Oswaldo Cruz 95 : 147–149.
  41. Wells DL, 2007. Public understanding of toxocariasis. Public Health 121 : 187–188.
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  • Received : 14 Nov 2007
  • Accepted : 30 Mar 2008

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