1921
Volume 79, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We investigated whether concurrent infection with , an intestinal nematode, modulated anti-malaria parasite immunity and development of experimental cerebral malaria (ECM) in mice. The C57BL/6 mice infected with ANKA showed typical symptoms of ECM. Interestingly, preceding infection did not alter ECM development, despite accelerated growth . Our observation provides a new insight that ECM can be induced in a fashion independent of the immune responses affected by concurrent . Differentiation between protective immunity and infection-associated host-damaging inflammatory response is urgently required for understanding the pathogenesis of cerebral malaria.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2008.79.819
2008-12-01
2017-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/79/6/0790819.html?itemId=/content/journals/10.4269/ajtmh.2008.79.819&mimeType=html&fmt=ahah

References

  1. van der Heyde HC, Nolan J, Combes V, Gramaglia I, Grau GE, 2006. A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to micro-circulatory dysfunction. Trends Parasitol 22 : 503–508.
  2. Medana IM, Chaudhri G, Chan-Ling T, Hunt NH, 2001. Central nervous system in cerebral malaria: “innocent bystander” or active participant in the induction of immunopathology? Immunol Cell Biol 79 : 101–120.
  3. van Riet E, Hartgers FC, Yazdanbakhsh M, 2007. Chronic helminth infections induce immunomodulation: consequences and mechanisms. Immunobiol 212 : 475–490.
  4. World Health Organization, 2004. Malaria cases (per 100,000) by country, latest available data. Available at: http://gamapserver.who.int/mapLibrary/Files/Maps/global_cases.jpg. Accessed April 8, 2008.
  5. World Health Organization, 2006. Soil-transmitted helminth (STH) infections are widely distributed in tropical and subtropical areas – 2006. Available at: http://www.who.int/intestinal_worms/epidemiology/map/en/index.html. Accessed April 8, 2008.
  6. Nacher M, Singhasivanon P, Yimsamran S, Manibunyong W, Thanyavanich N, Wuthisen P, Looareesuwan S, 2002. Intestinal helminth infections are associated with increased incidence of Plasmodium falciparum malaria in Thailand. J Parasitol 88 : 55–58.
  7. Nacher M, Gay F, Singhasivanon P, Krudsood S, Treeprasertsuk S, Mazier D, Vouldoukis I, Looareesuwan S, 2000. Ascaris lumbricoides infection is associated with protection from cerebral malaria. Parasite Immunol 22 : 107–113.
  8. Gause WC, Urban JF Jr, Stadecker MJ, 2003. The immune response to parasitic helminths: insights from murine models. Trends Immunol 24 : 269–277.
  9. Su Z, Segura M, Morgan K, Loredo-Osti JC, Stevenson MM, 2005. Impairment of protective immunity to blood-stage malaria by concurrent nematode infection. Infect Immun 73 : 3531–3539.
  10. Anthony RM, Urban JF Jr, Alem F, Hamed HA, Rozo CT, Boucher JL, van Rooijen N, Gause WC, 2006. Memory Th2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med 12 : 955–960.
  11. Finney CAM, Taylor MD, Wilson MS, Maizels RM, 2007. Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection. Eur J Immunol 37 : 1874–1886.
  12. Shear HL, Srinivasan R, Nolan T, Ng C, 1989. Role of IFN-γ in lethal and nonlethal malaria in susceptible and resistant murine hosts. J Immunol 143 : 2038–2044.
  13. Grau GE, Heremans H, Piguet PF, Pointaire P, Lambert PH, Billiau A, Vassalli P, 1989. Monoclonal antibody against interferon γ can prevent experimental cerebral malaria and its associated overproduction of tumour necrosis factor. Proc Natl Acad Sci USA 86 : 5572–5574.
  14. Wilson MS, Taylor MD, Balic A, Finney CAM, Lamb JR, Maizels RM, 2005. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 202 : 1199–1212.
  15. La Flamme AC, Ruddenklau K, Baecktroem BT, 2003. Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immun 71 : 4996–5004.
  16. Gruden-Movsesijan A, Ilic N, Mostarica-Stojkovic M, Stosic-Grujicic S, Milic M, Sofronic-Milosavljevic Lj, 2008. Trichinella spiralis: modulation of experimental autoimmune encephalomyelitis in DA rats. Exp Parasitol 118 : 641–647.
  17. Yanez DM, Manning DD, Cooley AJ, Weidanz WP, van der Heyde HC, 1996. Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria. J Immunol 157 : 1620–1624.
  18. Vinetz JM, Kumar S, Good MF, Fowlkes BJ, Berzofsky JA, Miller LH, 1990. Adoptive transfer of CD8+ cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria. J Immunol 144 : 1069–1074.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2008.79.819
Loading
/content/journals/10.4269/ajtmh.2008.79.819
Loading

Data & Media loading...

  • Received : 19 Apr 2008
  • Accepted : 20 Aug 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error