Volume 79, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We investigated whether concurrent infection with , an intestinal nematode, modulated anti-malaria parasite immunity and development of experimental cerebral malaria (ECM) in mice. The C57BL/6 mice infected with ANKA showed typical symptoms of ECM. Interestingly, preceding infection did not alter ECM development, despite accelerated growth . Our observation provides a new insight that ECM can be induced in a fashion independent of the immune responses affected by concurrent . Differentiation between protective immunity and infection-associated host-damaging inflammatory response is urgently required for understanding the pathogenesis of cerebral malaria.


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  • Received : 19 Apr 2008
  • Accepted : 20 Aug 2008

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