Volume 79, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Plague is a deadly infectious disease caused by the gram-negative bacterium, . In 2005, five plague patients were confirmed in the Yulong County of the Yunnan Province, China. In this study, the serologic survey of > 2,900 serum samples from domestic dogs and cats in and around the county, where human plague occurred, confirmed that domestic dogs and cats could serve as sentinel animals for plague surveillance. Meanwhile, the antibody responses in the infected dogs and cats were profiled by microarray containing 218 proteins of In addition to F1, LcrV, YPCD1.28c, and YPO2118 induced humoral responses in all or most of the individuals, providing complementary candidates to F1 antigen for diagnostic markers of plague.


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