1921
Volume 79, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We conducted a cross-sectional study of Chagas disease in five endemic areas in Argentina, Bolivia, Honduras, and México to estimate the prevalence of specific antibodies in pregnant women, and to assess the use of a rapid test (Chagas Stat-Pak) to screen for infection at the time of delivery. The prevalence of antibodies to measured by enzyme-linked immunosorbent assay (ELISA) in maternal blood was 5.5% (a range of 0.8–28.8% among the countries) in 2,495 women enrolled. Compared with ELISA in maternal blood samples, the Chagas Stat-Pak rapid test sensitivity and specificity in umbilical cord blood were 94.6% and 99.0%, respectively. These results show the ability for a rapid determination of the presence of specific antibodies in umbilical cord blood as a pragmatic strategy to screen for infection in pregnant women.

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2008-11-01
2017-11-20
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  • Received : 27 Mar 2008
  • Accepted : 01 Aug 2008

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