Volume 79, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Fasting could be an important factor in the induction of hypoglycemia in children with malaria because fasting results in a decrease in endogenous glucose production. The influence of extended fasting on plasma glucose concentration, glucose production, and gluconeogenesis were measured using [6,6-H]glucose and HO in 12 Surinamese children with severe malaria and compared with 16 children with non-severe malaria during a 16-hour controlled fast. Glucose concentration and glucose production were comparable after 8 hours of fasting and decreased in both groups ( < 0.001) with an extension of the fast up to 16 hours. Glucose concentration decreased faster in the non-severe group than in the severe group ( = 0.029). The decrease in glucose production was not different between groups ( = 0.954). Thus, fasting predisposes for hypoglycemia in young children with malaria. Hypoglycemia caused by fasting develops later in young children with severe malaria than in children with non-severe malaria.


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  • Received : 26 Jan 2008
  • Accepted : 08 Jul 2008

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