Volume 79, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The aim of this study was to investigate the interference of a daily treatment of dexamethasone in the pulmonary cycle of infection in rats. Three principal effects were found: 1) increased alveolar hemorrhagic inflammation provoked by the passage of larvae into alveolar spaces; 2) significant decrease of eosinophil and mast cell migration to the axial septum of the lungs; and 3) impaired formation of the reticular fiber network, interfering with granuloma organization. This study showed that the use of drugs with immunomodulatory actions, such as dexamethasone, in addition to interfering with the morbidity from the pulmonary cycle of infection, may contribute to showing the mechanisms involved in its pathogenesis.


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  • Received : 09 May 2008
  • Accepted : 17 Jul 2008

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