1921
Volume 79, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENV seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11 DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerase chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population.

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2008-10-01
2017-09-22
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References

  1. Tauil PL, 2006. Perspectivas de controle de doenças transmitidas por vetores no Brasil. Rev Soc Bras Med Trop 39 : 275–277.
  2. Siqueira JB, Martelli CMT, Coelho GE, Simplício ACR, Hatch DL, 2005. Dengue and dengue hemorrhagic fever, Brazil, 1981–2002. Emerg Infect Dis 11 : 48–53.
  3. Torres JR, Castro J, 2007. The health and economic impact of dengue in Latin America. Cad Saude Publica 23 (Suppl. 1): S23–S31.
  4. Chareonsook O, Foy HM, Teeraratkul A, Silarug N, 1999. Changing epidemiology of dengue hemorrhagic fever in Thailand. Epidemiol Infect 122 : 161–166.
  5. Strickman D, Sithiprasasna R, Kittayapong P, Innis BL, 2000. Distribution of dengue and Japanese encephalitis virus among children in rural and suburban Thai villages. Am J Trop Med Hyg 63 : 27–35.
  6. Lian CW, Seng CM, Chai WY, 2006. Spatial, environmental and entomological risk factor analysis on a rural dengue outbreak in Lundu District in Sarawak, Malaysia. Trop Biomed 23 : 85–96.
  7. Kumar A, Sharma SK, Padbidri VS, Thakare JP, Jain DC, Datta KK, 2001. An outbreak of dengue fever in rural areas of northern India. J Commun Dis 33 : 274–281.
  8. Tewari SC, Thenmozhi V, Katholi CR, Manavalan R, Munirathinam A, Gajanana A, 2004. Dengue vector prevalence and virus infection in a rural area in south India. Trop Med Int Health 9 : 499–507.
  9. Hayes CG, Phillips IA, Callahan JD, Griebenow WF, Hyams KC, Wu SJ, Watts DM, 1996. The epidemiology of dengue virus infection among urban, jungle, and rural populations in the Amazon Region of Peru. Am J Trop Med Hyg 55 : 459–463.
  10. Reiskind MH, Baisley KJ, Calampa C, Sharp TW, Watts DM, Wilson ML, 2001. Epidemiological and ecological characteristics of past dengue virus infection in Santa Clara, Peru. Trop Med Int Health 6 : 212–218.
  11. Silva-Nunes M, Malafronte Rdos S, Luz Bde A, Souza EA, Martins LC, Rodrigues SG, Chiang JO, Vasconcelos PF, Muniz PT, Ferreira MU, 2006. The Acre project: the epidemiology of malaria and arthropod-borne virus infections in a rural Amazonian population. Cad Saude Publica 22 : 1325–1334.
  12. Filmer D, Pritchett LH, 2001. Estimating wealth effects without expenditure data-or tear: an application to educational enrolments in states of India. Demography 38 : 115–132.
  13. Trape JF, 1985. Rapid evaluation of malaria parasite density and standardization of thick smear examination for epidemiological investigations. Trans R Soc Trop Med Hyg 79 : 181–184.
  14. de Souza VAF, Fernandes S, Araújo ES, Tateno AF, Oliveira OMNPF, Oliveira RR, Pannuti CS, 2004. Use of an immunoglobulin G avidity test to discriminate between primary and secondary dengue virus infections. J Clin Microbiol 42 : 1782–1784.
  15. Stefano I, Sato HK, Pannuti CS, Omoto TM, Mann G, Freire MS, Yamamura AM, Vasconcelos PF, Oselka GW, Weckx LW, Salgado MF, Noale LF, Souza VA, 1999. Recent immunization against measles does not interfere with the seroresponse to yellow fever vaccine. Vaccine 17 : 1042–1046.
  16. Freire MS, Mann GF, Marchevsky RS, Yamamura AMY, Almeida LFC, Jabor AV, Malachias JMN, Coutinho ESF, Galler R, 2005. Production of yellow fever 17DD vaccine in primary culture of chicken embryo fibroblasts: yields, thermo and genetic stability, attenuation and immunogenicity. Vaccine 23 : 250–252.
  17. Chomczynski P, Sacchi P, 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 : 156–159.
  18. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV, 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30 : 545–551.
  19. de Morais Bronzoni RV, Baleotti FG, Ribeiro Nogueira RM, Nunes M, Moraes Figueiredo LT, 2005. Duplex reverse transcription-PCR followed by nested PCR assays for detection and identification of Brazilian alphaviruses and flaviviruses. J Clin Microbiol 43 : 696–702.
  20. Tamura K, Dudley J, Nei M, Kumar S, 2007. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol Biol Evol 24 : 1596–1599.
  21. Regato M, Recarey R, Moratorio G, de Mora D, Garcia-Aguirre L, Gónzalez M, Mosquera C, Alava A, Fajardo A, Alvarez M, D’Andrea L, Dubra A, Martínez M, Khan B, Cristina J, 2008. Phylogenetic analysis of the NS5 gene of dengue viruses isolated in Ecuador. Virus Res 132 : 197–200.
  22. Baleotti FG, Moreli ML, Figueiredo LT, 2003. Brazilian Flavivirus phylogeny based on NS5. Mem Inst Oswaldo Cruz 98 : 379–382.
  23. Gubler DJ, Kuno G, Sather GE, Velez M, Oliver A, 1984. Use of mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue virus. Am J Trop Med Hyg 33 : 158–165.
  24. Vanwambeke SO, van Benthem BHB, Khantikul N, Burgoorn-Mass C, Panart K, Oskam L, Lambin EF, Somboon P, 2006. Multilevel analysis of spatial and temporal determinants for dengue infection. Int J Health Geogr 5 : 5.
  25. Kulldorff M, Nagarwalla N, 1995. Spatial disease clusters: detection and inference. Stat Med 14 : 799–819.
  26. Shope RE, Sather GE, 1979. Arboviruses. Lennette EH, Schmidt NJ, eds. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Fifth edition. Washington, DC: American Public Health Association, 767–814.
  27. Tavares-Neto J, Freitas-Carvalho J, Nunes MRT, Rocha G, Rodrigues SG, Damasceno E, Darub R, Viana S, Vasconcelos PFC, 2004. Pesquisa de anticorpos contra arbovírus e o v rus í vacinal da febre amarela em uma amostra da população de Rio Branco, antes e três meses após a vacina 17D. Rev Soc Bras Med Trop 37 : 1–6.
  28. Galler R, Marchevsky RS, Caride E, Almeida LFC, Yamamura AMY, Jabor AV, Motta MCA, Bonaldo MC, Coutinho ESF, Freire MS, 2005. Attenuation and immunogenicity of recombinant yellow fever 17D-dengue type 2 virus for rhesus monkeys. Braz J Med Biol Res 38 : 1835–1846.
  29. Aquino VH, Anatriello E, Gonçalves PF, da Silva EV, Vasconcelos PFC, Vieira DS, Batista WC, Bobadilla MI, Vazquez C, Morán M, Figueiredo LTM, 2006. Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002–2004. Am J Trop Med Hyg 75 : 710–715.
  30. Ministry of Health of Brazil, 2002. Programa Nacional de Controle da Dengue. Brasília: Ministério da Saúde.
  31. Endy TP, Nisalak A, Chunsuttiwat S, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA, 2002. Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol 156 : 52–59.
  32. Thai KTD, Binh TQ, Giao PT, Phuong HL, Hung LQ, Nam NV, Nga TT, Groen J, Nagelkerke N, de Vries PJ, 2005. Seroprevalence of dengue antibodies, annual incidence and risk factors among children in southern Vietnam. Trop Med Int Health 10 : 379–386.
  33. Balmasaeda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saborío SI, Mercado JC, Perez L, Videa E, Almanza E, Kuan G, Reyes M, Saenz L, Amador JJ, Harris E, 2006. High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health 11 : 935–942.
  34. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green AS, Rothman AL, Vaughn DW, Ennis FA, 2002. Epidemiology of innaparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol 156 : 40–51.
  35. Guha-Sapir D, Schimmer B, 2005. Dengue fever: new paradigms for a changing epidemiology. Emerg Themes Epidemiol 2 : 1.
  36. Kaplan JE, Eliason DA, Moore M, Sather GE, Schonberger LB, Cabrera-Coello L, Fernandez de Castro J, 1983. Epidemiological investigations of dengue infection in Mexico, 1980. Am J Epidemiol 117 : 335–343.
  37. Halsted SB, Nimmannitya S, Cohen SN, 1970. Observations related to pathogenesis of dengue hemorrhagic fever. IV Relation of disease severity to antibody response and virus recovered. Yale J Biol Med 42 : 311–328.
  38. Vasconcelos PFC, Lima JWO, Raposo ML, Rodrigues SG, Travassos da Rosa JFS, Amorim SMC, Travassos da Rosa ES, Moura CMP, Fonseca N, Travassos da Rosa APA, 1999. Inquérito soroepidemiológico na Ilha de São Luís durante epidemia de dengue no Maranhão. Rev Soc Bras Med Trop 32 : 171–179.
  39. Pan American Health Organization, 1994. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. Washington, DC: Pan American Health Organization.
  40. Nunes-Araújo FRF, Ferreira MS, Nishioka SA, 2003. Dengue fever in Brazilian adults and children: assessment of clinical findings and their validity for diagnosis. Ann Trop Med Parasitol 97 : 415–419.
  41. Rodrigues MBP, Freire HBM, Corrêa PRL, Mendonça ML, Silva MRI, França EB, 2005. Is it possible to identify dengue in children on the basis of Ministry of Health criteria for suspected dengue cases? J Pediatr (Rio J) 81 : 209–215.
  42. Dietz VJ, Gubler DJ, Rigau-Pérez JG, Pinheiro F, Schatzmayr HG, Bailey R, Gunn RA, 1990. Epidemic dengue 1 in Brazil, 1986: evaluation of a clinically based dengue surveillance system. Am J Epidemiol 131 : 693–701.
  43. Cunha RV, Schatzmayr HG, Miagostovich MP, Barbosa AMA, Paiva FP, Miranda RMO, Ramos CCF, Coelho JCO, Santos FB, Nogueira RMR, 1999. Dengue epidemic in the state of Rio Grande do Norte, Brazil, in 1997. Trans R Soc Trop Med Hyg 93 : 247–249.
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Appendix

  • Received : 11 Apr 2007
  • Accepted : 07 Jul 2008

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