Volume 79, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Clinical management of cystic echinococcosis (CE) has evolved over decades without adequate evaluation of important features such as efficacy, effectiveness, rate of adverse reactions, relapse rate, and cost. CE occurs in health care environments as different as Europe/North America and resource-poor countries of the South and the East. This creates setting-specific problems in the management of patients. Furthermore, studies carried out in either of the two fundamentally different environments lack external validity, i.e., results obtained in one setting may be different from those in the other and practices that can work in one may not be applicable to the other. In this paper, we review the current management procedures of CE with particular emphasis on the evidence base and setting-specific problems.


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  1. Drugs for Neglected Diseases initiative. Available at: http://www.dndi.org/. Accessed March 30, 2008.
  2. Budke CM, 2006. Global socioeconomic impact of cystic echinococcosis. Emerg Infect Dis 12 : 296–303.
  3. Kish MA, 2001. Guide to development of practice guidelines. Clin Infect Dis 32 : 851–854.
  4. Gharbi HA, Hassine W, Brauner MW, Dupuch K, 1981. Ultrasound examination of the hydatic liver. Radiology 139 : 459–463.
  5. Caremani M, Benci A, Maestrini R, Accorsi A, Caremani D, Lapini L, 1997. Ultrasound imaging in cystic echinococcosis. Proposal of a new sonographic classification. Acta Trop 67 : 91–105.
  6. WHO Informal Working Group on Echinococcosis, 2003. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop 85 : 253–261.
  7. Wang Y, Zhang X, Bartholomot B, Liu B, Luo J, Li T, Wen X, Zheng H, Zhou H, Wen H, Davaadori N, Gambolt L, Mukhar T, al-Qaoud K, Abdel-Hafez S, Giraudoux P, Vuitton DA, Fraser A, Rogan MT, Craig PS, 2003. Classification, follow-up and recurrence of hepatic cystic echinococcosis using ultrasound images. Trans R Soc Trop Med Hyg 97 : 203–211.
  8. Hosch W, Stojkovic M, Janisch T, Kauffmann GW, Junghanss T, 2007. The role of calcification for staging cystic echinococcosis (CE). Eur Radiol 17 : 2538–2545.
  9. Taylor BR, Langer B, 1997. Current surgical management of hepatic cyst disease. Adv Surg 31 : 127–148.
  10. Daradkeh S, El-Muhtaseb H, Farah G, Sroujieh AS, Abu-Khalaf M, 2007. Predictors of morbidity and mortality in the surgical management of hydatid cyst of the liver. Langenbecks Arch Surg 392 : 35–39.
  11. Demirci S, Eraslan S, Anadol E, Bozatli L, 1989. Comparison of the results of different surgical techniques in the management of hydatid cysts of the liver. World J Surg 13 : 88–90.
  12. Dogan R, Yuksel M, Cetin G, Suzer K, Alp M, Kaya S, Unlu M, Moldibi B, 1989. Surgical treatment of hydatid cysts of the lung: report on 1055 patients. Thorax 44 : 192–199.
  13. Ramos G, Orduna A, Garcia-Yuste M, 2001. Hydatid cyst of the lung: diagnosis and treatment. World J Surg 25 : 46–57.
  14. Isitmangil T, Sebit S, Tunc H, Gorur R, Erdik O, Kunter E, Toker A, Balkanli K, Ozturk OY, 2002. Clinical experience of surgical therapy in 207 patients with thoracic hydatidosis over a 12-year-period. Swiss Med Wkly 132 : 548–552.
  15. Little JM, Hollands MJ, Ekberg H, 1988. Recurrence of hydatid disease. World J Surg 12 : 700–704.
  16. Mawhorter S, Temeck B, Chang R, Pass H, Nash T, 1997. Non-surgical therapy for pulmonary hydatid cyst disease. Chest 112 : 1432–1436.
  17. Qian ZX, 1988. Thoracic hydatid cysts: a report of 842 cases treated over a thirty- year period. Ann Thorac Surg 46 : 342–346.
  18. Thameur H, Chenik S, Abdelmoulah S, Bey M, Hachicha S, Chemingui M, Mestiri T, Chaouch H, 2000. Thoracic hydatidosis. A review of 1619 cases. Rev Pneumol Clin 56 : 7–15.
  19. Menezes da Silva A, 2003. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop 85 : 237–242.
  20. Keramidas D, Mavridis G, Soutis M, Passalidis A, 2004. Medical treatment of pulmonary hydatidosis: complications and surgical management. Pediatr Surg Int 19 : 774–776.
  21. Vaquerizo A, Sola JL, Bondia A, Opla JM, Madariaga MJ, 1994. Intraoperative hydatid anaphylactic shock. Rev Esp Anestesiol Reanim 41 : 113–116.
  22. Manterola C, Fernandez O, Munoz S, Vial M, Losada H, Carrasco R, Bello N, Barroso M, 2002. Laparoscopic pericystectomy for liver hydatid cysts. Surg Endosc 16 : 521–524.
  23. Belghiti J, Benhamou JP, Houry S, Grenier P, Huguier M, Fekete F, 1986. Caustic sclerosing cholangitis. A complication of the surgical treatment of hydatid disease of the liver. Arch Surg 121 : 1162–1165.
  24. Castellano G, Moreno-Sanchez D, Gutierrez J, Moreno-Gonzalez E, Colina F, Solis-Herruzo JA, 1994. Caustic sclerosing cholangitis. Report of four cases and a cumulative review of the literature. Hepatogastroenterology 41 : 458–470.
  25. Atmatzidis KS, Pavlidis TE, Papaziogas BT, Mirelis C, Papaziogas TB, 2005. Recurrence and long-term outcome after open cystectomy with omentoplasty for hepatic hydatid disease in an endemic area. Acta Chir Belg 105 : 198–202.
  26. Dervisoglu A, Polat C, Hokelek M, Yetim I, Ozkutuk Y, Buyukkarabacak Y, Erzurumlu K, 2005. Videolaparoscopic treatment of hepatic hydatid cyst. Hepatogastroenterology 52 : 1526–1528.
  27. Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, Akdeniz A, Cetiner S, Tufan T, 2005. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 years experience with 355 patients. World J Surg 29 : 1670–1679.
  28. Dervenis C, Delis S, Avgerinos C, Madariaga J, Milicevic M, 2005. Changing concepts in the management of liver hydatid disease. J Gastrointest Surg 9 : 869–877.
  29. Sayek I, Onat D, 2001. Diagnosis and treatment of uncomplicated hydatid cyst of the liver. World J Surg 25 : 21–27.
  30. Demirleau JC, 1974. Treatment of hydatid cysts of the liver. Med Chir Dig 3 : 1–3.
  31. Morris DL, 1987. Pre-operative albendazole therapy for hydatid cyst. Br J Surg 74 : 805–806.
  32. Erzurumlu K, Hokelek M, Gonlusen L, Tas K, Amanvermez R, 2000. The effect of albendazole on the prevention of secondary hydatidosis. Hepatogastroenterology 47 : 247–250.
  33. Dhaliwal RS, Kalkat MS, 1997. One-stage surgical procedure for bilateral lung and liver hydatid cysts. Ann Thorac Surg 64 : 338–341.
  34. Langer JC, Rose DB, Keystone JS, Taylor BR, Langer B, 1984. Diagnosis and management of hydatid disease of the liver. A 15-year North American experience. Ann Surg 199 : 412–417.
  35. Little J, 1990. Hydatid disease of the liver. Hadfield J, Treasure T, eds. Current Surgical Practice. London: Hodder & Stoughton, 146–161.
  36. Magistrelli P, Masetti R, Coppola R, Messia A, Nuzzo G, Picciocchi A, 1991. Surgical treatment of hydatid disease of the liver. A 20-year experience. Arch Surg 126 : 518–522.
  37. Settaf A, Bargach S, Aghzadi R, Lahlou MK, Oudghiri M, 1991. Treatment of cystobiliary fistula of hydatid cyst of the liver. Apropos of 33 cases. J Chir (Paris) 128 : 133–138.
  38. Sayek I, Yalin R, Sanac Y, 1980. Surgical treatment of hydatid disease of the liver. Arch Surg 115 : 847–850.
  39. Yalin R, Oguz M, Dulger M, 1989. Surgical treatment of hepatic hydatid cyst. Med Principles Pract 1 : 154–159.
  40. Salih OK, Topcuoglu MS, Celik SK, Ulus T, Tokcan A, 1998. Surgical treatment of hydatid cysts of the lung: analysis of 405 patients. Can J Surg 41 : 131–135.
  41. Alfieri S, Doglietto GB, Pacelli F, Costamagna G, Carriero C, Mutignani M, Liberatori M, Crucitti F, 1997. Radical surgery for liver hydatid disease: a study of 89 consecutive patients. Hepatogastroenterology 44 : 496–500.
  42. Mueller PR, Dawson SL, Ferrucci JT Jr, Nardi GL, 1985. Hepatic echinococcal cyst: successful percutaneous drainage. Radiology 155 : 627–628.
  43. Filice C, Pirola F, Brunetti E, Dughetti S, Strosselli M, Foglieni CS, 1990. A new therapeutic approach for hydatid liver cysts. Aspiration and alcohol injection under sonographic guidance. Gastroenterology 98 : 1366–1368.
  44. Gargouri M, Ben Amor N, Ben Chehida F, Hammou A, Gharbi HA, Ben Cheikh M, Kchouk H, Ayachi K, Golvan JY, 1990. Percutaneous treatment of hydatid cysts (Echinococcus granulosus). Cardiovasc Intervent Radiol 13 : 169–173.
  45. Salama H, Farid Abdel-Wahab M, Strickland GT, 1995. Diagnosis and treatment of hepatic hydatid cysts with the aid of echo- guided percutaneous cyst puncture. Clin Infect Dis 21 : 1372–1376.
  46. Ustunsoz B, Akhan O, Kamiloglu MA, Somuncu I, Ugurel MS, Cetiner S, 1999. Percutaneous treatment of hydatid cysts of the liver: long-term results. AJR Am J Roentgenol 172 : 91–96.
  47. Men S, Hekimoglu B, Yucesoy C, Arda IS, Baran I, 1999. Percutaneous treatment of hepatic hydatid cysts: an alternative to surgery. AJR Am J Roentgenol 172 : 83–89.
  48. Brunetti E, Troia G, Garlaschelli AL, Gulizia R, Filice C, 2004. Twenty years of percutaneous treatments for cystic echinococcosis: a preliminary assessment of their use and safety. Parasitologia 46 : 367–370.
  49. Nasseri Moghaddam S, Abrishami A, Malekzadeh R, 2006. Percutaneous needle aspiration, injection, and reaspiration with or without benzimidazole coverage for uncomplicated hepatic hydatid cysts. Cochrane Database Syst Rev 2 : CD003623.
  50. Khuroo MS, Dar MY, Yattoo GN, Zargar SA, Javaid G, Khan BA, Boda MI, 1993. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology 104 : 1452–1459.
  51. Khuroo MS, Wani NA, Javid G, Khan BA, Yattoo GN, Shah AH, Jeelani SG, 1997. Percutaneous drainage compared with surgery for hepatic hydatid cysts. N Engl J Med 337 : 881–887.
  52. Akhan O, Ozmen MN, Dincer A, Sayek I, Gocmen A, 1996. Liver hydatid disease: long-term results of percutaneous treatment. Radiology 198 : 259–264.
  53. Goktay AY, Secil M, Gulcu A, Hosgor M, Karaca I, Olguner M, Akgur FM, Dicle O, 2005. Percutaneous treatment of hydatid liver cysts in children as a primary treatment: long-term results. J Vasc Interv Radiol 16 : 831–839.
  54. Giorgio A, Tarantino L, de Stefano G, Francica G, Mariniello N, Farella N, Perrotta A, Aloisio V, Esposito F, 2001. Hydatid liver cyst: an 11-year experience of treatment with percutaneous aspiration and ethanol injection. J Ultrasound Med 20 : 729–738.
  55. Smego RA Jr, Bhatti S, Khaliq AA, Beg MA, 2003. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Clin Infect Dis 37 : 1073–1083.
  56. Kabaalioglu A, Ceken K, Alimoglu E, Apaydin A, 2006. Percutaneous imaging-guided treatment of hydatid liver cysts: do long-term results make it a first choice? Eur J Radiol 59 : 65–73.
  57. Akhan O, Ozmen MN, 1999. Percutaneous treatment of liver hydatid cysts. Eur J Radiol 32 : 76–85.
  58. Yaghan R, Heis H, Bani-Hani K, Matalka I, Shatanawi N, Gharaibeh K, Bani-Hani A, 2004. Is fear of anaphylactic shock discouraging surgeons from more widely adopting percutaneous and laparoscopic techniques in the treatment of liver hydatid cyst? Am J Surg 187 : 533–537.
  59. El-On J, Ben-Noun L, Galitza Z, Ohana N, 2003. Case report: clinical and serological evaluation of echinococcosis of the spine. Trans R Soc Trop Med Hyg 97 : 567–569.
  60. Brunetti E, Filice C, 2001. Radiofrequency thermal ablation of echinococcal liver cysts. Lancet 358 : 1464.
  61. Bastid C, Ayela P, Sahel J, 2005. Percutaneous treatment of a complex hydatid cyst of the liver under sonographic control. Report of the first case. Gastroenterol Clin Biol 29 : 191–192.
  62. Brunetti E, Gulizia R, Garlaschelli A, Filice C, 2004. Radio-frequency thermal ablation of echinococcal cysts of the liver: results at 12-month follow-up. Am J Trop Med Hyg 71 : 182.
  63. Akhan O, Dincer A, Gokoz A, Sayek I, Havlioglu S, Abbasoglu O, Eryilmaz M, Besim A, Baris I, 1993. Percutaneous treatment of abdominal hydatid cysts with hypertonic saline and alcohol. An experimental study in sheep. Invest Radiol 28 : 121–127.
  64. Saremi F, McNamara TO, 1995. Hydatid cysts of the liver: long-term results of percutaneous treatment using a cutting instrument. AJR Am J Roentgenol 165 : 1163–1167.
  65. Vuitton DA, Zhi Wang X, Li Feng S, Sheng Chen J, Shou Li Y, Li SF, Ke Tang Q, 2002. PAIR-derived US-guided techniques for the treatment of cystic echinococcosis: a Chinese experience (e-letter). Gut.
  66. Haddad MC, Sammak BM, Al-Karawi M, 2000. Percutaneous treatment of heterogenous predominantly solid echopattern echinococcal cysts of the liver. Cardiovasc Intervent Radiol 23 : 121–125.
  67. Schipper HG, Lameris JS, van Delden OM, Rauws EA, Kager PA, 2002. Percutaneous evacuation (PEVAC) of multivesicular echinococcal cysts with or without cystobiliary fistulas which contain non-drainable material: first results of a modified PAIR method. Gut 50 : 718–723.
  68. Akhan O, Gumus B, Akinci D, Karcaaltincaba M, Ozmen M, 2007. Diagnosis and percutaneous treatment of soft-tissue hydatid cysts. Cardiovasc Intervent Radiol 30 : 419–425.
  69. Davis A, Dixon H, Pawlowski ZS, 1989. Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). Bull World Health Organ 67 : 503–508.
  70. Horton RJ, 1989. Chemotherapy of Echinococcus infection in man with albendazole. Trans R Soc Trop Med Hyg 83 : 97–102.
  71. Teggi A, Lastilla MG, De Rosa F, 1993. Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob Agents Chemother 37 : 1679–1684.
  72. Horton RJ, 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop 64 : 79–93.
  73. Nahmias J, Goldsmith R, Soibelman M, el-On J, 1994. Three- to 7-year follow-up after albendazole treatment of 68 patients with cystic echinococcosis (hydatid disease). Ann Trop Med Parasitol 88 : 295–304.
  74. Keshmiri M, Baharvahdat H, Fattahi SH, Davachi B, Dabiri RH, Baradaran H, Rajabzadeh F, 2001. Albendazole versus placebo in treatment of echinococcosis. Trans R Soc Trop Med Hyg 95 : 190–194.
  75. Gil-Grande LA, Rodriguez-Caabeiro F, Prieto JG, Sanchez-Ruano JJ, Brasa C, Aguilar L, Garcia-Hoz F, Casado N, Barcena R, Alvarez AI, Dal-Re R, 1993. Randomised controlled trial of efficacy of albendazole in intraabdominal hydatid disease. Lancet 342 : 1269–1272.
  76. Vutova K, Mechkov G, Vachkov P, Petkov R, Georgiev P, Handjiev S, Ivanov A, Todorov T, 1999. Effect of mebendazole on human cystic echinococcosis: the role of dosage and treatment duration. Ann Trop Med Parasitol 93 : 357–365.
  77. Chai J, Menghebat, Jiao W, Sun D, Liang B, Shi J, Fu C, Li X, Mao Y, Wang X, Dolikun, Guliber, Wang Y, Gao F, Xiao S, 2002. Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis. Chin Med J (Engl) 115 : 1809–1813.
  78. Radulescu S, Angelescu N, Horvat T, Lazar L, Cretu C, Popa L, Filiu P, Ene V, Burcos T, Ifrim S, Popa G, 1997. Clinical study of the efficacy of albendazole treatment in human hydatidosis. Chirurgia (Bucur) 92 : 331–335.
  79. Chai JJ, Monhebat, Sulitan Y, Jing Q, Chang Q, Zhang HL, 2003. Dynamic observation on ultrasonographic image during chemotherapy of hepatic cystic echinococcosis and a proposal for ultrasonic classification. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 21 : 134–139.
  80. Franchi C, Di Vico B, Teggi A, 1999. Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates. Clin Infect Dis 29 : 304–309.
  81. Shcherbakov AM, Panteleeva E, Firsova RA, 1993. The efficacy of the mebendazole treatment of patients with hydatid disease. Med Parazitol (Mosk) 4 : 15–17.
  82. Chai J, Menghebat, Wei J, Deyu S, Bin L, Jincao S, Chen F, Xiong L, Yiding M, Xiuling W, et al., 2004. Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis. Parasitol Int 53 : 3–10.
  83. Todorov T, Vutova K, Mechkov G, Georgiev P, Petkov D, Tonchev Z, Nedelkov G, 1992. Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole. Ann Trop Med Parasitol 86 : 59–66.
  84. el-Mufti M, Kamag A, Ibrahim H, Taktuk S, Swaisi I, Zaidan A, Sameen A, Shimbish F, Bouzghaiba W, Haasi S, Unaizi A, 1993. Albendazole therapy of hydatid disease: 2-year follow-up of 40 cases. Ann Trop Med Parasitol 87 : 241–246.
  85. Teggi A, Lastilla MG, De Rosa F, 1993. Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob Agents Chemother 37 : 1679–1684.
  86. Messaritakis J, Psychou P, Nicolaidou P, Karpathios T, Syriopoulou B, Fretzayas A, Krikos F, Matsaniotis N, 1991. High mebendazole doses in pulmonary and hepatic hydatid disease. Arch Dis Child 66 : 532–533.
  87. Todorov T, Vutova K, Mechkov G, Petkov D, Nedelkov G, Tonchev Z, 1990. Evaluation of response to chemotherapy of human cystic echinococcosis. Br J Radiol 63 : 523–531.
  88. Todorov T, Mechkov G, Vutova K, Georgiev P, Lazarova I, Tonchev Z, Nedelkov G, 1992. Factors influencing the response to chemotherapy in human cystic echinococcosis. Bull World Health Organ 70 : 347–358.
  89. Teggi A, Capozzi A, De Rosa F, 1989. Treatment of Echinococcus granulosus hydatid disease with mebendazole. J Chemother 1 : 310–317.
  90. Gil-Grande LA, Boixeda D, Garcia-Hoz F, Barcena R, Lledo A, Suarez E, Pascasio JM, Moreira V, 1983. Treatment of liver hydatid disease with mebendazole: a prospective study of thirteen cases. Am J Gastroenterol 78 : 584–588.
  91. Gocmen A, Toppare MF, Kiper N, 1993. Treatment of hydatid disease in childhood with mebendazole. Eur Respir J 6 : 253–257.
  92. Sciarrino E, Virdone R, Lo Iacono O, Fusco G, Ricca T, Cottone M, Maringhini A, Della Monica A, 1991. Ultrasound changes in abdominal echinococcosis treated with albendazole. J Clin Ultrasound 19 : 143–148.
  93. De Rosa F, Lastilla MG, Franchi C, Teggi A, 1996. Advances of medical treatment of human hydatidosis. Recenti Prog Med 87 : 346–352.
  94. Wen H, Zou PF, Yang WG, Lu J, Wang YH, Zhang JH, New RR, Craig PS, 1994. Albendazole chemotherapy for human cystic and alveolar echinococcosis in north-western China. Trans R Soc Trop Med Hyg 88 : 340–343.
  95. Keshmiri M, Baharvahdat H, Fattahi SH, Davachi B, Dabiri RH, Baradaran H, Ghiasi T, Rajabimashhadi MT, Rajabzadeh F, 1999. A placebo controlled study of albendazole in the treatment of pulmonary echinococcosis. Eur Respir J 14 : 503–507.
  96. Redondo PA, Alvarez AI, Garcia JL, Larrode OM, Merino G, Prieto JG, 1999. Presystemic metabolism of albendazole: experimental evidence of an efflux process of albendazole sulfoxide to intestinal lumen. Drug Metab Dispos 27 : 736–740.
  97. Lange H, Eggers R, Bircher J, 1988. Increased systemic availability of albendazole when taken with a fatty meal. Eur J Clin Pharmacol 34 : 315–317.
  98. Wen H, New RR, Muhmut M, Wang JH, Wang YH, Zhang JH, Shao YM, Craig PS, 1996. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co- administration with cimetidine. Parasitology 113 : 111–121.
  99. Mingjie W, Shuhua X, Junjie C, Bin L, Cheng F, Weixia S, Hotez P, 2002. Albendazole-soybean oil emulsion for the treatment of human cystic echinococcosis: evaluation of bioavailability and bioequivalence. Acta Trop 83 : 177–181.
  100. Nagy J, Schipper HG, Koopmans RP, Butter JJ, Van Boxtel CJ, Kager PA, 2002. Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability. Am J Trop Med Hyg 66 : 260–263.
  101. Homeida M, Leahy W, Copeland S, Ali MM, Harron DW, 1994. Pharmacokinetic interaction between praziquantel and albendazole in Sudanese men. Ann Trop Med Parasitol 88 : 551–559.
  102. Horton J, 2000. Albendazole: a review of anthelmintic efficacy and safety in humans. Parasitology 121 (Suppl): S113–S132.
  103. Morris DL, Smith PG, 1987. Albendazole in hydatid disease–hepatocellular toxicity. Trans R Soc Trop Med Hyg 81 : 343–344.
  104. Del Brutto OH, 2005. Neurocysticercosis. Semin Neurol 25 : 243–251.
  105. Teggi ALM, Grossi G, Franchi C, De Rosa F, 1995. Increase in serum glutamic-oxaloacetic and glutamic-pyruvic transaminases in patients with hydatid cysts treated with mebendazole and albendazole. Mediter J Inf Parasit Dis 10 : 85–90.
  106. Teggi A, Giattino M, Franchi C, Lastilla M, 1997. A hypothesis on the significance of an increase in serum transaminases in patients with hydatidosis treated with benzimidazole carbamates. Recenti Prog Med 88 : 452–458.
  107. Opatrny L, Prichard R, Snell L, Maclean JD, 2005. Death related to albendazole-induced pancytopenia: case report and review. Am J Trop Med Hyg 72 : 291–294.
  108. Bradley M, Horton J, 2001. Assessing the risk of benzimidazole therapy during pregnancy. Trans R Soc Trop Med Hyg 95 : 72–73.
  109. Romig T, Zeyhle E, Macpherson CN, Rees PH, Were JB, 1986. Cyst growth and spontaneous cure in hydatid disease. Lancet 1 : 861.
  110. Frider B, Larrieu E, Odriozola M, 1999. Long-term outcome of asymptomatic liver hydatidosis. J Hepatol 30 : 228–231.
  111. Brunetti E, Troìa G, Gulizia R, Garlaschelli AL, Filice C, 2005. “Watch and Wait” as an alternative “treatment” for active and transitional echinococcal cysts. Single-center experience. Am J Trop Med Hyg 73 : 29.
  112. Hosch W, Junghanss T, Stojkovic M, Brunetti E, Heye T, Kauffman GW, Hull WE, 2008. Metabolic viability assessment of cystic echinococcosis using high-field 1H magnetic resonance spectroscopy of cyst contents. NMR Biomed Apr 3 [Epub ahead of print].
  113. Hosch W, Stojkovic M, Janisch T, Heye T, Werner J, Friess H, Kauffmann GW, Junghanss T, 2008. MR imaging for diagnosing cysto-biliary fistulas in cystic echinococcosis. Eur J Radiol 66 : 262–267.
  114. WHO Informal Working Group on Echinococcosis, 1996. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ 74 : 231–242.
  115. Ostanello F, Piccolomini LL, Martinello F, Vizioli M, Battelli G, 1997. Echinococcosis/hydatidosis in Emilia-Romagna: a study of hospital admissions in the period of 1989–1993. Epidemiol Prev 21 : 41–47.

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  • Received : 29 Aug 2007
  • Accepted : 13 Apr 2008

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