1921
Volume 79, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary; from them, 73 were DHF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2008.79.262
2008-08-01
2017-09-24
Loading full text...

Full text loading...

/deliver/fulltext/14761645/79/2/0790262.html?itemId=/content/journals/10.4269/ajtmh.2008.79.262&mimeType=html&fmt=ahah

References

  1. Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 : 480–496.
  2. World Health Organization, 1999. Strengthening Implementation of the Global Strategy for Dengue/Dengue Hemorrhagic Fever Prevention and Control. Geneva: World Health Organization.
  3. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6 : 118–124.
  4. Kouri G, Mas P, Guzman MG, Soler M, Goyenechea A, Morier L, 1983. Dengue hemorrhagic fever in Cuba, 1981: rapid diagnosis of the etiologic agent. Bull Pan Am Health Organ 17 : 126–132.
  5. Kafati R, 2002. Situación epidemiológica del dengue clásico y hemorragico en Honduras y el papel relevante del médico. Rev Med Hond 70 : 56.
  6. Honduras, Secretaría de Salud Pública, 2002. Programa Nacional de Dengue Epidemiología. Boletín Semanal Enfermedades transmisibles.
  7. Honduras, Secretaría de Salud Pública, 2004. Programa Nacional de Dengue Epidemiología. Boletín Semanal Enfermedades transmisibles.
  8. Honduras, Secretaría de Salud Pública, 2005. Programa Nacional de Dengue Epidemiología. Boletín Semanal Enfermedades transmisibles.
  9. PAHO, 2006. Number of reported cases of dengue and dengue hemorrhagic fever (DHF), region of the Americas (by country and subregion). Available at: www.paho.org/English/AD/DPC/CD/dengue-cases-2006.htm. Accessed July 1, 2008.
  10. Vazquez S, Valdes O, Pupo M, Delgado I, Alvarez M, Pelegrino JL, Guzman MG, 2003. MAC-ELISA and ELISA inhibition methods for detection of antibodies after yellow fever vaccination. J Virol Methods 110 : 179–184.
  11. Vazquez S, Perez AB, Ruiz D, Rodriguez R, Pupo M, Calzada N, González L, González D, Castro O, Serrano T, Guzmán MG, 2005. Serological markers during Dengue 3 primary and secondary infections. J Clin Virol 33 : 132–137.
  12. Clark DH, Casals J, 1958. Techniques for hemagglutination inhibition with arthropodborne viruses. Am. J. Trop. Hyg. 7 : 561–573.
  13. Halstead SB, 1970. Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion. Yale J Biol Med 42 : 350–362.
  14. Rosen L, 1977. The Emperor’s New Clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever. Am J Trop Med Hyg 26 : 337–343.
  15. Kouri GP, Guzman MG, Bravo JR, 1987. Why dengue haemorrhagic fever in Cuba? 2. An integral analysis. Trans R Soc Trop Med Hyg 81 : 821–823.
  16. Guzman MG, Kouri G, Halstead SB, 2000. Do escape mutants explain rapid increases in dengue case-fatality rates within epidemics? Lancet 355 : 1902–1903.
  17. Kurane I, Takasaki T, 2001. Dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large. Rev Med Virol 11 : 301–311.
  18. Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC, 2001. Immunopathogenesis of dengue virus infection. J Biomed Sci 8 : 377–388.
  19. Guzman MG, Alvarez M, Rodriguez R, Rosario D, Vazquez S, Vald SL, Cabrera MV, Kouri G, 1999. Fatal dengue hemorrhagic fever in Cuba, 1997. Int J Infect Dis 3 : 130–135.
  20. Guzman MG, Kouri G, 2002. Dengue: an update. Lancet Infect Dis 2 : 33–42.
  21. Kliks SC, Nimmanitya S, Nisalak A, Burke DS, 1988. Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg 38 : 411–419.
  22. Guzman MG, Kouri G, Bravo J, Soler M, Morier L, Vazquez S, Diaz A, Fernandez R, Ruiz A, Ramos A, et al., 1986. Dengue in Cuba: history of an epidemic. PAHO Bull 20 : 24–30.
  23. Halstead SB, 2002. Dengue. Curr Opin Infect Dis 15 : 471–476.
  24. Hongsiriwon S, 2002. Dengue hemorrhagic fever in infants. Southeast Asian J Trop Med Public Health 33 : 49–55.
  25. Pengsaa K, Luxemburger C, Sabchareon A, Limkittikul K, Yoksan S, Chambonneau L, Chaovarind U, Sirivichayakul C, Lapphra K, Chanthavanich P, Lang J, 2006. Dengue virus infections in the first 2 years of life and the kinetics of transplacentally transferred dengue neutralizing antibodies in thai children. J Infect Dis 194 : 1570–1576.
  26. Gamble J, Bethell D, Day NP, Loc PP, Phu NH, Gartside IB, Farrar JF, White NJ, 2000. Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock? Clin Sci (Lond) 98 : 211–216.
  27. Halstead SB, 2006. Dengue in Americas and Southeast Asia: Do they differ? Rev Panam Salud Publica 20 : 407–414.
  28. Balmaseda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saborio SI, Mercado JC, Perez L, Videa E, Almanza E, Kuan G, Reyes M, Saenz L, Amador JJ, Harris E, 2006. High sero-prevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health 11 : 935–942.
  29. PAHO, 2000. Dengue in Central America: the epidemics of 2000. Epidemiol Bull 21 : 4–8.
  30. Acosta N, 2006. Evaluación de la Respuesta de Anticuerpos IgG a Virus Dengue en Diferentes Grupos Poblacionales. Virología. Ciudad de la Habana, Cuba: Facultad de Biología, Universidad de la Habana.
  31. Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH, 1989. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 40 : 418–427.
  32. Nogueira RM, Miagostovich MP, Cavalcanti SM, Marzochi KB, Schatzmayr HG, 1992. Levels of IgM antibodies against dengue virus in Rio de Janeiro, Brazil. Res Virol 143 : 423–427.
  33. Summers PL, Eckels KH, Dalrymple JM, Scott RM, Boyd VA, 1984. Antibody response to dengue-2 vaccine measured by two different radioimmunoassay methods. J Clin Microbiol 19 : 651–659.
  34. Balmaseda A, Guzman MG, Hammond S, Robleto G, Flores C, Tellez Y, Videa E, Saborio S, Perez L, Sandoval E, Rodriguez Y, Harris E, 2003. Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. Clin Diagn Lab Immunol 10 : 317–322.
  35. Groen J, Velzing J, Copra C, Balentien E, Deubel V, Vorndam V, Osterhaus AD, 1999. Diagnostic value of dengue virus-specific IgA and IgM serum antibody detection. Microbes Infect 1 : 1085–1090.
  36. Talarmin A, Labeau B, Lelarge J, Sarthou JL, 1998. Immunoglobulin A-specific capture enzyme-linked immunosorbent assay for diagnosis of dengue fever. J Clin Microbiol 36 : 1189–1192.
  37. Vazquez S, Cabezas S, Perez AB, Pupo M, Ruiz D, Calzada N, Bernardo L, Castro O, Gonzalez D, Serrano T, Sanchez A, Guzman MG, 2007. Kinetics of antibodies in sera, saliva, and urine samples from adult patients with primary or secondary dengue 3 virus infections. IJID 11 : 256–262.
  38. Koraka P, Suharti C, Setiati TE, Mairuhu AT, Van Gorp E, Hack CE, Juffrie M, Sutaryo J, Van Der Meer GM, Groen J, Osterhaus AD, 2001. Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol 39 : 4332–4338.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2008.79.262
Loading
/content/journals/10.4269/ajtmh.2008.79.262
Loading

Data & Media loading...

  • Received : 17 Oct 2007
  • Accepted : 13 May 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error