1921
Volume 79, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

To better understand the clinical and laboratory characteristics and to identify risk factor(s) for fatality in elderly patients with dengue hemorrhagic fever (DHF), 66 elderly (age ≥ 65 years) and 241 non-elderly adults (age, 19–64 years) with DHF were retrospectively analyzed. Compared with non-elderly adults, elderly individuals had significantly lower incidences of fever ( = 0.002), abdominal pain ( = 0.003), bone pain ( < 0.001), and skin rashes ( = 0.002); higher frequencies of concurrent bacteremia ( = 0.049), gastrointestinal bleeding ( = 0.044), acute renal failure ( = 0.001), and pleural effusion ( < 0.010); higher incidence of prolonged prothrombin time ( = 0.025); lower mean hemoglobin level ( < 0.001); longer hospitalization ( = 0.049); and a higher fatality rate ( = 0.006). Five elderly patients with DHF died. When compared with non-fatal elderly patients with DHF, a significant higher frequency in men ( = 0.019), those with chronic obstructive pulmonary disease ( = 0.008), those with dengue shock syndrome (DSS; < 0.001), and those with acute renal failure ( < 0.001) was found in the elderly counterparts that died. Multivariate analysis showed that only DSS (odd ratio = 77.33, = 0.001) was an independent risk factor for fatality in elderly patients.

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2008-08-01
2017-09-20
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  • Received : 02 Oct 2007
  • Accepted : 10 Apr 2008

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