Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Scrub typhus, caused by is a zoonosis that spreads rapidly in Shandong, China. To investigate the molecular characterization of in new and old epidemic areas in Shandong Province, we compared the genetic relationships of between Linyi and Tai’an districts, typical old and new epidemic areas in Shandong, respectively. was detected in blood from 12 of 16 patients in Linyi and in eschar from 3 of 4 patients in Tai’an; 17 of 128 rodents were found to be infected with in Linyi, and 4 of 68 rodents were found to be -positive in Tai’an. The results indicated less genetic variation in between the new and old epidemic areas, and the Sdu-1 type, similar to Japan Kawasaki, was the main genotype of in Shandong Province.


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  1. Tamura A, Ohashi N, Urakami H, Miyamura S, 1995. Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. Int J Syst Bacteriol 45 : 489–591.
  2. Wisseman CL, 1991. Rickettsial infections. Strickland GT, ed. Hunter’s Tropical Medicine. Seventh edition. Philadelphia: WB Saunders, 256–286.
  3. Ebisawa II, 1995. Current epidemiology and treatment of tsutsugamushi disease in Japan. J Travel Med 2 : 218–220.
  4. Panpanich R, Garner P, 2000. Antibiotics for treating scrub typhus. Cochrane Database Syst Rev 2000(2): CD002150.
  5. Yu ES, 1997. Analysis on the current epidemiological characteristics of scrub typhus in China. Chin J Epidemiol 18 : 56.
  6. Wu GH, 2000. Epidemiological study on scrub typhus in China—present status and prospects. Chin J Infect Dis 18 : 142–144.
  7. Zhang LJ, Fu XP, Fan MY, 2005. Research on Rickettsia and epidemiological status of rickettsiosis in China. Chin J Trop Med Parasitol 3 : 37–42.
  8. Yang YF, Wang JL, Yao YC, 1987. A survey on scrub typhus found first time in Shandong Province. Chin J Epidemiol 8 : 280.
  9. Feng MQ, Yang DY, Zhang W, Xu LF, Cui S, 1989. A report of scrub typhus prevailed firstly in Eastern Jinan. Shandong Med J 29 : 35–37.
  10. Huang Y, Jia FJ, Li YM, 2003. Analysis of the epidemic status of tsutsugamushi disease in Shandong Province. Endemic Dis Bull 18 : 36–38.
  11. Chen LB, Tian FJ, Sun T, Wang XJ, Du XG, Ma LZ, Huang JT, Li Z, Lin ZL, Kong LS, Wang DQ, Cheng WC, 1997. A report of scrub typhus prevailed firstly in Rencheng of Jining District. Chin J Zoon 13 : 70–71.
  12. Liu DB, Xu XH, Mao YP, Pan B, 1998. Report on the first outbreak of scrub typhus in Laizhou Town, Yantai District. Disease Surveillance 13 : 470–471.
  13. Qin KG, Yang SZ, Zhang LY, Li LP, 2002. Clinical investigation of initial prevalence of scrub typhus in Qingzhou Town, Weifang District. Chin J Parasit Dis Con 15 : 12.
  14. Wang ZW, Liu WD, Li ZK, Zhu HB, 2001. Investigation on the first outbreak of scrub typhus in Feicheng Town, Tai’an District. Disease Surveillance 16 : 307–308.
  15. Wang XJ, Wang QZ, Li Z, 2003. Study on scrub typhus in Shan-dong Province. Chin J Zoon 19 : 95–97.
  16. Yao JL, 2004. Scrub typhus. Peng WW, ed. Infectious Diseases. Sixth edition. Beijing: People’s Medical Publishing House, 118–121.
  17. Yang ZQ, Liu YX, Yu XM, Wu QY, Xing RY, 2000. Investigation on natural foci of autumn–winter type tsutsugamushi disease in Shandong Province. Chin J Epidemiol 21 : 283–286.
  18. Furuya Y, Yoshida Y, Katayama T, Yamamoto S, Kawamura A Jr, 1993. Serotype-specific amplification of Rickettsia tsutsugamushi DNA by nested polymerase chain reaction. J Clin Microbiol 31 : 1637–1640.
  19. Tamura A, Yamamoto N, Koyama S, Makisaka Y, Takahashi M, Urabe K, Takaoka M, Nakazawa K, Urakami H, Fukuhara M, 2001. Epidemiological survey of Orientia tsutsugamushi distribution in field rodents in Saitama Prefecture, Japan, and discovery of a new type. Microbiol Immunol 45 : 439–446.
  20. Kumar S, Tamura K, Nei M, 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5 : 150–163.
  21. Wang QZ, Wang XJ, Sun T, Li Z, Ding SJ, Feng KJ, Cui H, Hu B, 2003. Seroepidemiological investigation on scrub typhus in Shandong Province. Chin J Vector Biol Control 14 : 130–132.
  22. Yang LP, Zhao ZT, Liu YX, Feng YQ, Wang XJ, Li Z, 2006. Genotype identification and sequence analysis of Orientia tsutsugamushi isolated from Shandong region. Chin J Epidemiol 27 : 49–52.

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  • Received : 03 Sep 2007
  • Accepted : 01 Mar 2008

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