1921
Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

45W proteins are good candidates for development of anti-cysticercosis vaccines. However, the genetic characteristics of the 45 gene family are still unclear between different isolates. We investigated the polymorphism of the 45 gene family between Chinese and Mexican . Alignment showed that TSO45-4B and TSO45-1C antigens were conserved absolutely, whereas other TSO45 proteins varied between these two isolates. It is informative to guide using of recombinant 45W vaccines to control porcine cysticercosis caused by Asiatic or African/ Latin American .

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2008-06-01
2017-11-22
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References

  1. Sciutto E, Fragoso G, Fleury A, Laclette JP, Sotelo J, Aluja A, Vargas L, 2000. Taenia solium disease in humans and pigs: an ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensions. Microbes Infect 2 : 1875–1890.
  2. Del Brutto OH, Dolezal M, Castillo PR, Garcia HH, 2000. Neurocysticercosis and oncogenesis. Arch Med Res 31 : 151–155.
  3. Lightowlers MW, 1999. Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. Int J Parasitol 29 : 811–817.
  4. Flisser A, Gauci CG, Zoli A, Martinez-Ocana J, Garza-Rodriguez A, Dominguez-Alpizar JL, Maravilla P, Rodriguez-Canul R, Avila G, Aguilar-Vega L, Kyngdon C, Geerts S, Lightowlers MW, 2004. Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infect Immun 72 : 5292–5297.
  5. Gonzalez AE, Gauci CG, Barber D, Gilman RH, Tsang VC, Garcia HH, Verastegui M, Lightowlers MW, 2005. Vaccination of pigs to control human neurocysticercosis. Am J Trop Med Hyg 72 : 837–839.
  6. Gauci CG, Lightowlers MW, 2001. Alternative splicing and sequence diversity of transcripts from the oncosphere stage of Taenia solium with homology to the 45W antigen of Taenia ovis. Mol Biochem Parasitol 112 : 2173–2181.
  7. Nakao M, Okamoto M, Sako Y, Yamasaki H, Nakaya K, Ito A, 2002. A phylogenetic hypothesis for the distribution of two genotypes of the pig tapeworm Taenia solium worldwide. Parasitology 124 : 657–662.
  8. Ito A, Yamasaki H, Nakao M, Sako Y, Okamoto M, Sato MO, Nakaya K, Margono SS, Ikejima T, Kassuku AA, Afonso SM, Ortiz WB, Plancarte A, Zoli A, Geerts S, Craig PS, 2003. Multiple genotypes of Taenia solium—ramifications for diagnosis, treatment and control. Acta Trop 87 : 95–101.
  9. Gauci CG, Ito A, Lightowlers MW, 2006. Conservation of the vaccine antigen gene, TSOL18, among genetically variant isolates of Taenia solium. Mol Biochem Parasitol 146 : 101–104.
  10. Gauci CG, Lightowlers MW, 1995. Developmental regulation of Taenia ovis 45W gene expression. Mol Biochem Parasitol 73 : 263–266.
  11. Stevenson P, 1983. Observations on the hatching and activation of fresh Taenia saginata eggs. Ann Trop Med Parasitol 77 : 399–404.
  12. Lightowlers MW, Gauci CG, Chow C, Drew DR, Gauci SM, Heath DD, Jackson DC, Dadley-Moore DL, Read AJ, 2003. Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites. Int J Parasitol 33 : 1207–1217.
  13. Johnson KS, Harrison GBL, Lightowlers MW, O’Hoy KL, Dempster RP, Lawrence SB, Vinton JG, Heath DD, Rickard MD, 1989. Vaccination against ovine cysticercosis using a defined recombinant antigen. Nature 338 : 585–587.
  14. Luo X, Zheng Y, Dou Y, Guo A, Hou J, Jing Z, Cai X, 2007. Combining expression and protective efficacy of 45W-4BX and 18kD from different stages of Taenia solium. Sci Agr Sin 40 : 385–390.
  15. Luo X, Zheng Y, Hu Z, Ding J, Dou Y, Guo A, Jing Z, Cai X, 2008. High efficacious expression and immune efficacy of 45W-4BX and TSOL18 from Taenia solium oncosphere. Acta Vet Zootech Sin 39 : 212–217.
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  • Received : 27 Nov 2007
  • Accepted : 09 Feb 2008

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