1921
Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Patent and pathologic infections of the human hookworm were established in the common marmoset (). In a pilot study, a laboratory strain of was compared with a fresh field isolate. Pathology was more severe in animals infected with a fresh isolate. In all animals, infection was associated with increased total plasma IgE and production of IgG specific to adult worm excretory/secretory (ES) products. Histamine was released by basophils in response to IgE, ES products, and a recombinant hookworm allergen, calreticulin. The pilot study indicated the potential of this animal model of hookworm infection and led us to investigate the consequences of infecting a further cohort with the fresh field isolate. This second study confirmed our initial findings, that it is possible to investigate the human hookworm in a model exhibiting many of the characteristics of the immunology of hookworm infection in its definitive host.

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  • Received : 01 Dec 2005
  • Accepted : 31 Jan 2008

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