1921
Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Men are more than 7 times more likely to develop amebic liver abscess or amebic dysentery caused by than women. Because the complement system could play a key role in controlling amebiasis, we determined whether serum from men and women differ in the ability to kill amebic trophozoites. We found that serum from women was significantly more effective in killing trophozoites than serum from men, and this killing was complement dependent. Our results provide a possible explanation for the differential susceptibility of men and women to amebic liver abscess and amebic colitis.

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/content/journals/10.4269/ajtmh.2008.78.922
2008-06-01
2017-09-24
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References

  1. Stanley SL Jr, 2003. Amoebiasis. Lancet 361 : 1025–1034.
  2. Acuna-Soto R, Maguire JH, Wirth DF, 2000. Gender distribution in asymptomatic and invasive amebiasis. Am J Gastroenterol 95 : 1277–1283.
  3. Stanley SL Jr, Jackson TFHG, Reed SL, Calderon J, Kunz-Jenkins C, Gathiram V, Li E, 1991. Serodiagnosis of invasive amebiasis using a recombinant Entamoeba histolytica protein. JAMA 266 : 1984–1986.
  4. Hamelmann C, Foerster B, Burchard GD, Horstmann RD, 1992. Lysis of pathogenic and nonpathogenic Entamoeba histolytica by human complement: methodological analysis. Parasite Immunol 14 : 23–35.
  5. Glumac G, Mates A, Eidinger D, 1976. The heterocytotoxicity of human serum. III. Studies of the serum levels and distribution of activity in human populations. Clin Exp Immunol 26 : 601–608.
  6. Brai M, Tolone G, Magro A, Waks H, Brai M, 1976. Alternative complement pathway: activity levels in allogeneic pregnancy. Experientia 32 : 1589–1591.
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  • Received : 21 Nov 2007
  • Accepted : 17 Feb 2008

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