Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Men are more than 7 times more likely to develop amebic liver abscess or amebic dysentery caused by than women. Because the complement system could play a key role in controlling amebiasis, we determined whether serum from men and women differ in the ability to kill amebic trophozoites. We found that serum from women was significantly more effective in killing trophozoites than serum from men, and this killing was complement dependent. Our results provide a possible explanation for the differential susceptibility of men and women to amebic liver abscess and amebic colitis.


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  • Received : 21 Nov 2007
  • Accepted : 17 Feb 2008
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