Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Although the disease burden of dengue is increasing, the impact on the quality of life (QoL) has not been investigated. A study to determine the QoL of confirmed dengue patients using the EuroQol visual thermometer scale was carried out at the University Malaya Medical Center. Of the 207 participants, 40% were ambulatory and 60% were hospitalized. Of eight health domains, 6.2 and 5.0 domains were affected in the hospitalized and ambulatory cohorts, respectively ( < 0.001), with cognition and interpersonal activities affected most. All patients experienced a drastic decrease in their QoL from the onset of symptoms. The QoL deteriorated to the lowest point (40% of healthy status) between the third and seventh days of illness. The duration of impaired QoL (9 days for ambulatory or 13 days for hospitalized patients) was longer than the duration of fever (5 and 7 days, respectively). Symptomatic dengue has major effects on patients’ health.


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  1. World Health Organization, 2006. DengueNet. Available at: http://www.who.int/csr/disease/dengue/denguenet/en/index.html. Accessed September 26, 2007.
  2. Suaya JA, Shepard DS, Beatty ME, 2007. Dengue Burden of Disease and Cost of Illness. Scientific Working Group: Report on Dengue. Geneva: World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases, TDR/SWG/08.
  3. Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue haemorrhagic fever. Lancet 352 : 971–977.
  4. World Health Organization, April 2002. Dengue and Dengue Haemorrhagic Fever. Fact Sheet No. 17. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/print.html. Accessed September 26, 2007.
  5. Gubler DJ, Meltzer M, 1999. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res 53 : 35–70.
  6. Fang R, Lo E, Lim TW, 1984. The 1982 dengue epidemic in Malaysia: epidemiological, serological and virological aspects. Southeast Asian J Trop Med Public Health 15 : 51–57.
  7. Rudnick A, Tan EE, Lucas JK, Omar MB, 1965. Mosquito-borne haemorrhagic fever in Malaya. BMJ 1 : 1269–1272.
  8. Poovaneswari S, 1993. Dengue situation in Malaysia. Malays J Pathol 15 : 3–7.
  9. Ministry of Health of Malaysia, 1975–2006. Division of Vector Borne Disease Control Programme: Annual Reports of Vector Borne Disease Control Programme. Kuala Lumpur, Malaysia: Ministry of Health of Malaysia.
  10. Ooi EE, Goh KT, Gubler DJ, 2006. Dengue prevention and 35 years of vector control in Singapore. Emerg Infect Dis 12 : 887–893.
  11. Goh KT, 1997. Dengue: a re-emerging infectious disease in Singapore. Ann Acad Med Singapore 26 : 664–670.
  12. Lee MS, Hwang KP, Chen TC, Lu PL, Chen TP, 2006. Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic. J Microbiol Immunol Infect 39 : 121–129.
  13. Kittigul L, Pitakarnjanakul P, Sujirarat D, Siripanichgon K, 2007. The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection. J Clin Virol 39 : 76–81.
  14. Hammond SN, Balmaseda A, Pérez L, Tellez Y, Saborío SI, Mercado JC, Videa E, Rodriguez Y, Pérez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Gonzalez A, Harris E, 2005. Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg 73 : 1063–1070.
  15. Malavige GN, Velathanthiri VG, Wijewickrama ES, Fernando S, Jayaratne SD, Aaskov J, Seneviratne SL, 2006. Patterns of disease among adults hospitalized with dengue infections. QJM 99 : 299–305.
  16. Kularatne SA, Gawarammana IB, Kumarasiri PR, 2005. Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka. Southeast Asian J Trop Med Public Health 36 : 686–692.
  17. Ellis AK, Verma S, 2000. Quality of life in women with urinary tract infections: is benign disease a misnomer? J Am Board Fam Pract 13 : 392–397.
  18. Jeffrey AL, Singer DE, 2003. Health-related quality of life of adults with upper respiratory tract infections. J Gen Intern Med 18 : 802–807.
  19. Rigau Perez JG, 1998. The early use of break-bone fever (Quebrabta huesos, 1771) and dengue (1801) in Spanish. Am J Trop Med Hyg 19 : 272–274.
  20. EuroQol Group, 1990. EuroQol-A new facility for the measurement of health-related quality of life. Health Policy (New York) 16 : 199–208.
  21. World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization,
  22. SPSS, 2006. Version 14. Chicago, IL: SPSS Inc.
  23. Ng CF, Lum LC, Ismail NA, Tan LH, Tan CP, 2007. Clinicians’ diagnostic practice of dengue infections. J Clin Virol 40 : 202–206.
  24. Guzmán MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6 : 118–124.
  25. Guzman MG, Kouri G, Valdes L, Bravo J, Vazquez S, Halstead SB, 2002. Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks. Pan Am J Public Health 11: 223–227.
  26. Low JG, Ooi EE, Tolfvenstam T, Leo YS, Hibberd ML, Ng LC, Lai YL, Yap GS, Li CS, Vasudevan SG, Ong A, 2006. Early dengue infection and outcome study (EDEN)—study design and preliminary findings. Ann Acad Med Singapore 35 : 783–789.
  27. Murray CJ, Salomon JA, Mathers CD, Lopez AD, 2002. Summary Measures of Population Health. Concepts, Ethics, Measurement and Applications. Geneva: World Health Organization.
  28. Prosser LA, Hammitt J, Keren R, 2007. Measuring health preferences for use in cost-utility and cost-benefit analyses of interventions in children: theoretical and methodological considerations. Pharmacoeconomics 25 : 713–726.
  29. O’Leary JF, Fairclough DL, Jankowski MK, Weeks JC, 1995. Comparison of time-tradeoff utilities and rating scale values of cancer patients and their relatives: evidence for a possible plateau relationship. Med Decis Making 15 : 132–137.
  30. Salomon JA, Murray CJ, 2004. A multi-method approach to measuring health-state evaluations. Health Econ 13 : 281–290.

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  • Received : 15 Dec 2007
  • Accepted : 11 Mar 2008

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