Volume 78, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted infection in 100% of C3H/HeJ mice ( = 16), as well as cured acute, established infection in mice ( = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.


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  • Received : 16 Jan 2008
  • Accepted : 15 Feb 2008

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