1921
Volume 78, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Reduced paraoxonase-1 (PON1) activity has been observed in a number of pathological conditions; however, little is known about the effects of intestinal nematode infections, such as , on paraoxonase activity. We observed a significant reduction in serum paraoxonase and arylesterase activity after infection in Wistar rats from Day 6 until Day 12 post-infection (p.i.) for serum paraoxonase and from Day 3 until Day 24 p.i. for arylesterase. In addition, infection increased serum concentrations of pro-inflammatory cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-α), with maximum concentrations observed on Day 9 p.i. These cytokines are known to inhibit the synthesis of hepatic PON1 mRNA. Thus, the observed reduction in PON1 activity during infection is likely associated with inflammatory reactions mounted against the parasites.

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  • Received : 02 Nov 2007
  • Accepted : 27 Feb 2008

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