Volume 78, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of from the New World was assessed using models. Azithromycin decreased viability of promastigote cultures of () , () and () as determined by the colorimetric Alamar blue assay. In amastigote intracellular cultures, a significant decrease in infected macrophages counts was observed for all three species with IC of 20.83 (27 μ mol/L), 2.18 (2.7 μmol/L), and 6.12 (7.8 μmol/L) μg/mL, respectively. Azithromycin showed activity against . (.) , . (.) and . (.) and may offer an alternative to current leishmaniasis treatment.


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  • Received : 06 Nov 2007
  • Accepted : 16 Feb 2008

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