1921
Volume 78, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

is the second most prevalent global species causing malaria after . These two spp. co-exist in most endemic areas, apart from west and central Africa, which has only . However, southeastern Turkey is one of the exceptional regions with the sole presence of infection, where a thorough epidemiologic survey has not been performed. Here, we report for the first time the identification of naturally acquired antibodies against the 19-kd C-terminal region of the merozoite surface protein-1 of (PvMSP1), using ELISA, from residents in the Sanliurfa region of southeastern Turkey. Among the 82 samples from patients with patent malaria, 85% of the individuals were sero-reactive to PvMSP1. Particularly, 69.5% of the subjects were positive for IgM, 53.6% were positive for IgG (predominantly IgG1 and IgG3), and 7.3% were positive for IgA.

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2008-05-01
2017-09-26
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References

  1. Aslan G, Seyrek A, Kocagoz T, Ulukanligil M, Erguven S, Gunalp A, 2007. The diagnosis of malaria and identification of plasmodium species by polymerase chain reaction in Turkey. Parasitol Int 56 : 217–220.
  2. Ballou WR, Arevalo-Herrera M, Carucci D, Richie TL, Corradin G, Diggs C, Druilhe P, Giersing BK, Saul A, Heppner DG, Kester KE, Lanar DE, Lyon J, Hill AV, Pan W, Cohen JD, 2004. Update on the clinical development of candidate malaria vaccines. Am J Trop Med Hyg 71 : 239–247.
  3. Egan AF, Morris J, Barnish G, Allen S, Greenwood BM, Kaslow DC, Holder AA, Riley EM, 1996. Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen, PfMSP-1. J Infect Dis 173 : 765–769.
  4. John CC, O’Donnell RA, Sumba PO, Moormann AM, de Koning-Ward TF, King CL, Kazura JW, Crabb BS, 2004. Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J Immunol 173 : 666–672.
  5. Conway DJ, Cavanagh DR, Tanabe K, Roper C, Mikes ZS, Sakihama N, Bojang KA, Oduola AM, Kremsner PG, Arnot DE, Greenwood BM, McBride JS, 2000. A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses. Nat Med 6 : 689–692.
  6. Soares IS, Levitus G, Souza JM, Del Portillo HA, Rodrigues MM, 1997. Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria. Infect Immun 65 : 1606–1614.
  7. Park JW, Moon SH, Yeom JS, Lim KJ, Sohn MJ, Jung WC, Cho YJ, Jeon KW, Ju W, Ki CS, Oh MD, Choe K, 2001. Naturally acquired antibody responses to the C-terminal region of merozoite surface protein 1 of Plasmodium vivax in Korea. Clin Diagn Lab Immunol 8 : 14–20.
  8. Good MF, Stanisic D, Xu H, Elliott S, Wykes M, 2004. The immunological challenge to developing a vaccine to the blood stages of malaria parasites. Immunol Rev 201 : 254–267.
  9. Herrera S, Corradin G, Arévalo-Herrera M, 2007. An update on the search for a Plasmodium vivax vaccine. Trends Parasitol 23 : 122–128.
  10. Tanabe K, Sakihama N, Walliker D, Babiker H, Abdel-Muhsin AA, Bakote’e B, Ohmae H, Arisue N, Horii T, Rooth I, Färnert A, Björkman A, Ranford-Cartwright L, 2007. Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1. Gene 392 : 153–160.
  11. Ak M, Jones TR, Charoenvit Y, Kumar S, Kaslow DC, Maris D, Marwoto H, Masbar S, Hoffman SL, 1998. Humoral immune responses against Plasmodium vivax MSP1 in humans living in a malaria endemic area in Flores, Indonesia. Southeast Asian J Trop Med Public Health 29 : 685–691.
  12. Morais CG, Soares IS, Carvalho LH, Fontes CJ, Krettli AU, Braga EM, 2005. IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil. Parasitol Res 95 : 420–426.
  13. Wickramarachchi T, Illeperuma RJ, Perera L, Bandara S, Holm I, Longacre S, Handunnetti SM, Udagama-Randeniya PV, 2007. Comparison of naturally acquired antibody responses against the C-terminal processing products of Plasmodium vivax Merozoite Surface Protein-1 under low transmission and unstable malaria conditions in Sri Lanka. Int J Parasitol 37 : 199–208.
  14. Zeyrek FY, Kurcer MA, Zeyrek D, Simsek Z, 2006. Parasite density and serum cytokine levels in Plasmodium vivax malaria in Turkey. Parasite Immunol 28 : 201–207.
  15. Kaslow DC, Kumar S, 1996. Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv200(19), secreted from Saccharomyces cerevisiae. Immunol Lett 51 : 187–189.
  16. Zeyrek FY, Korkmaz M, Ozbel Y, 2007. Serodiagnosis of Anthroponotic Cutaneous Leishmaniasis (ACL) Caused by Leishmania tropica in Sanliurfa Province, Turkey, Where ACL Is Highly Endemic. Clin Vaccine Immunol 14 : 1409–1415.
  17. O’Donnell RA, de Koning-Ward TF, Burt RA, Bockarie M, Reeder JC, Cowman AF, Crabb BS, 2001. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med 193 : 1403–1412.
  18. Omosun YO, Anumudu CI, Adoro S, Odaibo AB, Sodeinde O, Holder AA, Nwagwu M, Nwuba RI, 2005. Variation in the relationship between anti-MSP-1(19) antibody response and age in children infected with Plasmodium falciparum during the dry and rainy seasons. Acta Trop 95 : 233–247.
  19. Pitabut N, Panichakorn J, Mahakunkijcharoen Y, Hirunpetcharat C, Looareesuwan S, Khusmith S, 2007. IgG antibody profile to c-terminal region of Plasmodium vivax merozoite surface protein-1 in Thai individuals exposed to malaria. Southeast Asian J Trop Med Public Health 38 : 1–7.
  20. Lim KJ, Park JW, Yeom JS, Lee YH, Yoo SB, Oh JH, Sohn MJ, Bahk YY, Kim YS, 2004. Humoral responses against the C-terminal region of merozoite surface protein 1 can be remembered for more than 30 years in persons exposed to Plasmodium vivax. Parasitol Res 92 : 384–389.
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  • Received : 10 Dec 2007
  • Accepted : 29 Jan 2008

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