Volume 78, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We describe the first molecular confirmation of , the cause of Rocky Mountain spotted fever (RMSF), from a tick vector, , and from a cluster of fatal spotted fever cases in Argentina. Questing ticks were collected at or near sites of presumed or confirmed cases of spotted fever rickettsiosis in Jujuy Province and evaluated by polymerase chain reaction assays for spotted fever group rickettsiae. DNA of was amplified from a pool of ticks and from tissues of one of four patients who died during 2003–2004 after illnesses characterized by high fever, severe headache, myalgias, and petechial rash. The diagnosis of spotted fever rickettsiosis was confirmed in the other patients by indirect immunofluorescence antibody and immunohistochemical staining techniques. These findings show the existence of RMSF in Argentina and emphasize the need for clinicians throughout the Americas to consider RMSF in patients with febrile rash illnesses.


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  • Received : 04 Oct 2007
  • Accepted : 29 Dec 2007

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