Volume 78, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. The purpose of this study was to assess the pathogenicity of Choclo virus in hamsters. None of 18 hamsters infected with Choclo virus exhibited any symptom of disease. No evidence of inflammation or edema was found in the lungs of the 10 animals killed on days 7, 9, 11, 13, and 16 post-inoculation or in the lungs of the 8 animals killed on day 28 post-inoculation; however, hantavirus antigen was present in large numbers of endothelial cells in the microvasculature of the lungs of the animals killed on days 7, 9, 11, and 13 post-inoculation. These results suggest that infection in the microvasculature of lung tissue alone does not result in the life-threatening pulmonary edema in hamsters infected with Andes virus.


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  1. Centers for Disease Control and Prevention (CDC), 1993. Outbreak of acute illness—southwestern United States, 1993. MMWR Morb Mortal Wkly Rep 42 : 421–424.
  2. Stephen C, Johnson M, Bell A, 1994. First reported cases of hantavirus pulmonary syndrome in Canada. Can Commun Dis Rep 20 : 121–125.
  3. Vincent MJ, Quiroz E, Gracia F, Sanchez AJ, Ksiazek TG, Kitsutani PT, Ruedas LA, Tinnin DS, Caceres L, Garcia A, Rollin PE, Mills JN, Peters CJ, Nichol ST, 2000. Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs. Virology 277 : 14–19.
  4. da Silva MV, Vasconcelos MJ, Hidalgo NT, Veiga AP, Canzian M, Marotto PC, de Lima VC, 1997. Hantavirus pulmonary syndrome. Report of the first three cases in Sao Paulo, Brazil. Rev Inst Med Trop Sao Paulo 39 : 231–234.
  5. López N, Padula P, Rossi C, Lázaro ME, Franze-Fernández MT, 1996. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220 : 223–226.
  6. Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST, 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238 : 115–127.
  7. Centers for Disease Control and Prevention (CDC), 1997. Hantavirus pulmonary syndrome—Chile, 1997. MMWR Morb Mortal Wkly Rep 46 : 949–951.
  8. Padula PJ, Colavecchia SB, Martínez VP, González Della Valle MO, Edelstein A, Miguel SD, Russi J, Riquelme JM, Colucci N, Almiron M, Rabinovich RD, 2000. Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America. J Clin Microbiol 38 : 3029–3035.
  9. Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1995. A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. J Virol 69 : 1980–1983.
  10. Khan AS, Gaviria M, Rollin PE, Hlady WG, Ksiazek TG, Armstrong LR, Greenman R, Ravkov E, Kolber M, Anapol H, Sfakianaki ED, Nichol ST, Peters CJ, Khabbaz RF, 1996. Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus. Am J Med 100 : 46–48.
  11. Hjelle B, Lee SW, Song W, Torrez-Martinez N, Song JW, Yanagihara R, Gavrilovskaya I, Mackow ER, 1995. Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus. J Virol 69 : 8137–8141.
  12. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917.
  13. Nichol ST, Beaty BJ, Elliott RM, Goldbach R, Plyusnin A, Schmaljohn CS, Tesh RB, 2005. Family Bunyaviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, eds.Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses. San Diego, CA: Elsevier Academic Press, pp. 695–716.
  14. Milazzo ML, Cajimat MNB, Hanson JD, Bradley RD, Quintana M, Sherman C, Velasquez RT, Fulhorst CF, 2006. Catacamas virus, a hantaviral species naturally associated with Oryzomys couesi (Coues’ oryzomys) in Honduras. Am J Trop Med Hyg 75 : 1003–1010.
  15. Fulhorst CF, Cajimat MNB, Utrera A, Milazzo ML, Duno GM, 2004. Maporal virus, a hantavirus associated with the fulvous pygmy rice rat (Oligoryzomys fulvescens) in western Venezuela. Virus Res 104 : 139–144.
  16. Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO, Gage KL, Rollin PE, Sarisky J, Enscore RE, Frey JK, Peters CJ, Nichol ST, 1994. Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169 : 1271–1280.
  17. Calderon G, Pini N, Bolpe J, Levis S, Mills J, Segura E, Guthmann N, Cantoni G, Becker J, Fonollat A, Ripoll C, Bortman M, Benedetti R, Enria D, 1999. Hantavirus reservoir hosts associated with peridomestic habitats in Argentina. Emerg Infect Dis 5 : 792–797.
  18. Cantoni G, Padula P, Calderon G, Mills J, Herrero E, Sandoval P, Martinez V, Pini N, Larrieu E, 2001. Seasonal variation in prevalence of antibody to hantaviruses in rodents from southern Argentina. Trop Med Int Health 6 : 811–816.
  19. Levis S, Morzunov SP, Rowe JE, Enria D, Pini N, Calderon G, Sabattini M, St Jeor SC, 1998. Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177 : 529–538.
  20. Torres-Perez F, Navarrete-Droguett J, Aldunate R, Yates TL, Mertz GJ, Vial PA, Ferres M, Marquet PA, Palma RE, 2004. Peridomestic small mammals associated with confirmed cases of human hantavirus disease in southcentral Chile. Am J Trop Med Hyg 70 : 305–309.
  21. Koster FT, Levy H, 2006. Hantavirus cardiopulmonary syndrome: a new twist to an established pathogen. In: Fong IW, Alibek K, eds. New and Evolving Infections of the 21 st Century. New York: Springer-Verlag, pp. 151–170.
  22. Vapalahti O, Lundkvist A, Vaheri A, 2001. Human immune response, host genetics, and severity of disease. Curr Top Microbiol Immunol 256 : 153–169.
  23. Nolte KB, Feddersen RM, Foucar K, Zaki SR, Koster FT, Madar D, Merlin TL, McFeeley PJ, Umland ET, Zumwalt RE, 1995. Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent. Hum Pathol 26 : 110–120.
  24. Hallin GW, Simpson SQ, Crowell RE, James DS, Koster FT, Mertz GJ, Levy H, 1996. Cardiopulmonary manifestations of hantavirus pulmonary syndrome. Crit Care Med 24 : 252–258.
  25. Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K, Feddersen RM, Zumwalt RE, Miller GL, Khan AS, Rollin PE, Ksiazek TG, Nichol TS, Mahy BWJ, Peters CJ, 1995. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 146 : 552–579.
  26. Hooper JW, Larsen T, Custer DM, Schmaljohn CS, 2001. A lethal disease model for hantavirus pulmonary syndrome. Virology 289 : 6–14.
  27. Meissner JD, Rowe JE, Borucki MK, St Jeor SC, 2002. Complete nucleotide sequence of a Chilean hantavirus. Virus Res 89 : 131–143.
  28. Milazzo ML, Eyzaguirre EJ, Molina CP, Fulhorst CF, 2002. Maporal viral infection in the Syrian golden hamster: a model of hantavirus pulmonary syndrome. J Infect Dis 186 : 1390–1395.
  29. Sundstrom JB, McMullan LK, Spiropoulou CF, Hooper WC, Ansari AA, Peters CJ, Rollin PE, 2001. Hantavirus infection induces the expression of RANTES and IP-10 without causing increased permeability in human lung microvascular endothelial cells. J Virol 75 : 6070–6085.
  30. Terajima M, Hayasaka D, Maeda K, Ennis FA, 2007. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with real syndrome: do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett 113 : 117–120.
  31. Mori M, Rothman AL, Kurane I, Montoya JM, Nolte KB, Norman JE, Waite DC, Koster FT, Ennis FA, 1999. High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis 179 : 295–302.
  32. Hayasaka D, Maeda K, Ennis FA, Terajima M, 2007. Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes. Virus Res 123 : 120–127.
  33. Wahl-Jensen V, Chapman J, Asher L, Fisher R, Zimmerman M, Larsen T, Hooper JW, 2007. Temporal analysis of Andes virus and Sin Nombre virus infection of Syrian hamsters. J Virol 81 : 7449–7462.

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  • Received : 18 Jul 2007
  • Accepted : 18 Jan 2008

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