1921
Volume 78, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic–pharmacodynamic evaluations of DHA in murine models.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2008.78.641
2008-04-01
2017-11-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/78/4/0780641.html?itemId=/content/journals/10.4269/ajtmh.2008.78.641&mimeType=html&fmt=ahah

References

  1. Davis TM, Karunajeewa HA, Ilett KF, 2005. Artemisinin-based combination therapies for uncomplicated malaria. Med J Aust 182 : 181–185.
  2. Kremsner PG, Krishna S, 2004. Antimalarial combinations. Lancet 364 : 285–294.
  3. Ilett KF, Batty KT, 2005. Artemisinin and its derivatives. Yu VL, Edwards G, McKinnon PS, Peloquin C, Morse GD, eds. Antimicrobial Therapy and Vaccines, Vol. II: Antimicrobial Agents. Baltimore: Williams & Wilkins, 981–1001.
  4. White NJ, 2002. The assessment of antimalarial drug efficacy. Trends Parasitol 18 : 458–464.
  5. International Artemisinin Study Group, 2004. Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363 : 9–17.
  6. Peters W, Robinson BL, 1999. Malaria. Zak O, Sande MA, eds. Handbook of Animal Models of Infection. San Diego: Academic Press, 757–773.
  7. China Cooperative Research Group, 1982. Metabolism and pharmacokinetics of qinghaosu and its derivatives. J Trad Chin Med 2 : 25–30.
  8. Li QG, Peggins JO, Fleckenstein LL, Masonic K, Heiffer MH, Brewer TG, 1998. The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats. J Pharm Pharmacol 50 : 173–182.
  9. Rajanikanth M, Madhusudanan KP, Gupta RC, 2003. An HPLC-MS method for simultaneous estimation of α,β-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study. Biomed Chromatogr 17 : 440–446.
  10. Sabarinath S, Madhusudanan KP, Gupta RC, 2005. Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats. Biopharm Drug Dispos 26 : 211–223.
  11. Li Q, Xie LH, Si Y, Wong E, Upadhyay R, Yanez D, Weina PJ, 2005. Toxicokinetics and hydrolysis of artelinate and artesunate in malaria-infected rats. Int J Toxicol 24 : 241–250.
  12. Xing J, Yan HX, Zhang SQ, Ren G, Gao Y, 2006. A high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemisinin in rat plasma. Rapid Commun Mass Spectrom 20 : 1463–1468.
  13. Xing J, Yan HX, Wang RL, Zhang LF, Zhang SQ, 2007. Liquid chromatography-tandem mass spectrometry assay for the quantitation of β-dihydroartemisinin in rat plasma. J Chromatogr B 852 : 202–207.
  14. Lewis SM, Bain BJ, Bates I, 2006. Practical Haematology. Tenth edition. Philadelphia: Churchill Livingstone.
  15. Batty KT, Davis TM, Thu LT, Binh TQ, Anh TK, Ilett KF, 1996. Selective high-performance liquid chromatographic determination of artesunate and α- and β-dihydroartemisinin in patients with falciparum malaria. J Chromatogr B 677 : 345–350.
  16. Bailer AJ, 1988. Testing for the equality of area under the curves when using destructive measurement techniques. J Pharmacokinet Biopharm 16 : 303–309.
  17. Yuan J, 1993. Estimation of variance for AUC in animal studies. J Pharm Sci 82 : 761–763.
  18. Binh TQ, Ilett KF, Batty KT, Davis TME, Hung NC, Powell SM, Thu LTA, Thien HV, Phuong HL, Phuong VDB, 2001. Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria. Br J Clin Pharmacol 51 : 541–546.
  19. Batty KT, Ilett KF, Powell SM, Martin J, Davis TME, 2002. Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers. Am J Trop Med Hyg 66 : 130–136.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2008.78.641
Loading
/content/journals/10.4269/ajtmh.2008.78.641
Loading

Data & Media loading...

  • Received : 07 Jul 2007
  • Accepted : 02 Jan 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error