1921
Volume 78, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

During home visits and using a point-of-care test for brucellosis, we screened the household members of adult patients found to have brucellosis by investigation at the Hospital Nacional Daniel Alcides Carrión in Callao, Peru. A total of 206 household members of 43 patients were screened, and 15 (7.3%) household members in 10 (23.3%) households tested seropositive. Brucellosis was diagnosed in 14 of them, all but 4 presenting with acute or subacute uncomplicated disease. Regardless of attempts to control brucellosis in Peru, the disease continues to be reasonably common among household members of brucellosis patients. Household members presumably remain the single most important identifiable risk group in an urban setting, and screening them provides an effective means for their early diagnosis. Although contact with livestock was rare, the consumption of unpasteurized dairy products was reported by almost all patients with brucellosis, their household members, and hospitalized non-brucellosis patients.

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References

  1. Guillen A, Navarro AM, Acosta M, Arrelucé M, 1989. Brucellosis epidemiology. Annals of the National Seminary of Zoonoses and Foodborne Diseases. Lima: Ministry of Health, 48–65.
  2. Godfroid J, Cloeckaert A, Liautard JP, Kohler S, Fretin D, Walravens K, Garin-Bastuji B, Letesson JJ, 2005. From the discovery of the Malta fever’s agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis. Vet Res 36 : 313–326. [Google Scholar]
  3. Young EJ, 1995. An overview of human brucellosis. Clin Infect Dis 21 : 283–289. [Google Scholar]
  4. Corbel MJ, 1997. Brucellosis: an overview. Emerg Infect Dis 3 : 213–221. [Google Scholar]
  5. Young EJ, 1989. Brucellosis: Clinical and Laboratory Aspects. Boca Raton, FL: CRC Press.
  6. Young EJ, 2003. Brucella species (Brucellosis). Yu VL, Weber R, Raoult D, eds. Antimicrobial, Therapy and Vaccines. Volume I: Microbes. New York: Apple Tree Productions, 121–140.
  7. Al Dahouk S, Tomaso H, Nockler K, Neubauer H, Frangoulidis D, 2003. Laboratory-based diagnosis of brucellosis—a review of the literature. Part I: techniques for direct detection and identification of Brucella spp. Clin Lab 49 : 487–505. [Google Scholar]
  8. Bikas C, Jelastopulu E, Leotsinidis M, Kondakis X, 2003. Epidemiology of human brucellosis in a rural area of north-western Peloponnese in Greece. Eur J Epidemiol 18 : 267–274. [Google Scholar]
  9. Al-Shamahy HA, Whitty CJ, Wright SG, 2000. Risk factors for human brucellosis in Yemen: a case control study. Epidemiol Infect 125 : 309–313. [Google Scholar]
  10. Hasanjani Roushan MR, Mohrez M, Smailnejad Gangi SM, Soleimani Amiri MJ, Hajiahmadi M, 2004. Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect 132 : 1109–1114. [Google Scholar]
  11. Jennings GJ, Hajjeh RA, Girgis FY, Fadeel MA, Maksoud MA, Wasfy MO, El-Sayed N, Srikantiah P, Luby SP, Earhart K, Mahoney FJ, 2007. Brucellosis as a cause of acute febrile illness in Egypt. Trans R Soc Trop Med Hyg 101 : 707–713. [Google Scholar]
  12. Omer MK, Assefaw T, Skjerve E, Tekleghiorghis T, Woldehiwet Z, 2003. Prevalence of antibodies to Brucella spp. and risk factors related to high-risk occupational groups in Eritrea. Epidemiol Infect 129 : 85–91. [Google Scholar]
  13. Spink WW, 1954. Family studies on brucellosis. Am J Med Sci 222 : 240–243. [Google Scholar]
  14. Abramson O, Rosenvasser Z, Block C, Dagan R, 1991. Detection and treatment of brucellosis by screening a population at risk. Ped Infect Dis J 10 : 434–438. [Google Scholar]
  15. Almuneef MA, Memish ZA, Balkhy HH, Qahtani M, Alotaibi B, Hajeer A, Qasim L, Al Knawy B, 2004. Importance of screening household members of acute brucellosis cases in endemic areas. Epidemiol Infect 132 : 533–540. [Google Scholar]
  16. Alsubaie S, Almuneef M, Alshaalan M, Balkhy H, Albanyan E, Alola S, Alotaibi B, Memish ZA, 2005. Acute brucellosis in Saudi families: relationship between Brucella serology and clinical symptoms. Intern J Infect Dis. 9 : 218–224. [Google Scholar]
  17. Gotuzzo E, Seas C, Guerra JG, Carrillo C, Bocanegra TS, Calvo A, Castañeda O, Alarcón GS, 1987. Brucellar arthritis: a study of 39 Peruvian families. Ann Rheum Dis 46 : 506–509. [Google Scholar]
  18. Smits HL, Abdoel TH, Solera J, Clavijo E, Diaz R, 2003. Immunochromatographic Brucella-specific immunoglobulin M and G lateral flow assays for rapid serodiagnosis of human brucellosis. Clin Diagn Lab Immunol 10 : 1141–1146. [Google Scholar]
  19. Irmak H, Buzgan T, Evirgen O, Akdeniz H, Demiroz AP, Abdoel TH, Smits HL, 2004. Use of the Brucella IgM and IgG flow assays in the serodiagnosis of human brucellosis in an area endemic for brucellosis. Am J Trop Med Hyg 70 : 688–694. [Google Scholar]
  20. Kose S, Smits HL, Abdoel TH, Ozbel Y, 2006. Prevalence of Brucella antibodies in rural and suburban communities in three provinces of Turkey: need for improved diagnosis and prevention. J Infect 53 : 308–314. [Google Scholar]
  21. Hasanjani Roushan MR, Soleimani Amin MJ, Abdoel TH, Smits HL, 2005. Application of a rapid and simple Brucella-specific IgM and IgG antibody test for the serodiagnosis of brucellosis in a hospital in Iran. Trans R Soc Trop Med Hyg 99 : 744–750. [Google Scholar]
  22. Zeytinog lu A, Turhan A, Altug lu I, Bilgiç A, Abdoel TH, Smits HL, 2006. Comparison of Brucella immunoglobulin M and G flow assays with serum agglutination and 2-mercaptoethanol tests in the diagnosis of brucellosis. Clin Chem Lab Med 44 : 180–184. [Google Scholar]
  23. Al Dahouk S, Tomaso H, Nockler K, Neubauer H, Frangoulidis D, 2003. Laboratory-based diagnosis of brucellosis—a review of the literature. Part II: serological tests for brucellosis. Clin Lab 49 : 577–589. [Google Scholar]
  24. Alton GG, Jones LM, Pietz DF, 1975. WHO Laboratory Techniques in Brucellosis. Geneva: World Health Organization.
  25. Martin-Moreno S, Guinea-Esquerdo L, Carrero-Gonzalez P, Visedo-Orden R, García-Arbajosa S, Calvo del Olmo T, Reverte-Cejudo D, 1992. Diagnosis of brucellosis in an endemic area. Evaluation of routine diagnostic tests. Med Clin (Barc) 98 : 481–485. [Google Scholar]
  26. Mantur BG, Mangalgi SS, 2004. Evaluation of conventional Castaneda and lysis centrifugation blood culture techniques for diagnosis of human brucellosis. J Clin Microbiol 42 : 4327–4328. [Google Scholar]
  27. Rasouli M, Kiany S, 2007. Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients. Cytokine 38 : 49–53. [Google Scholar]
  28. Budak F, Göral G, Heper Y, Yilmaz E, Aymak F, Baştürk B, Töre O, Ener B, Oral HB, 2007. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in brucellosis. Cytokine 38 : 32–36. [Google Scholar]
  29. Bravo MJ, Colmenero JD, Martín J, Alonso A, Caballero A, 2007. Polymorphism of the transmembrane region of the MICA gene and human brucellosis. Tissue Antigens 69 : 358–360. [Google Scholar]
  30. Bravo MJ, de Dios Colmenero J, Alonso A, Caballero A, 2003. Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis. Eur J Immunogenet 30 : 433–435. [Google Scholar]
  31. Rezazadeh M, Hajilooi M, Rafiei A, Haidari M, Nikoopour E, Kerammat F, Mamani M, Ranjbar M, Hashemi H, 2006. TLR4 polymorphism in Iranian patients with brucellosis. J Infect 53 : 206–210. [Google Scholar]
  32. Spink WW, Anderson D, 1950. Transmission of Brucella. J Lab Clin Med 35 : 440–443. [Google Scholar]
  33. Celebi G, Külah C, Kiliç S, Ustündag G, 2007. Asymptomatic Brucella bacteraemia and isolation of Brucella melitensis biovar 3 from human breast milk. Scand J Infect Dis 39 : 205–208. [Google Scholar]
  34. Al-Attas RA, Al-Khalifa M, Al-Qurashi AR, Badawy M, Al-Gualy N, 2000. Evaluation of PCR, culture and serology for the diagnosis of acute human brucellosis. Ann Saudi Med 20 : 224–228. [Google Scholar]
  35. Hardy AV, Frant S, Kroll MM, 1938. Incubation period of Brucella. Publ Hlth Rep 53 : 796–797. [Google Scholar]
  36. Minas A, Minas M, Stournara A, Tselepidis S, 2004. The “effects” of Rev-1 vaccination of sheep and goats on human brucellosis in Greece. Prev Vet Med 64 : 41–47. [Google Scholar]
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  • Received : 20 Sep 2007
  • Accepted : 03 Jan 2008

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