1921
Volume 78, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Specific polymerase chain reaction (PCR) protocols were used to determine the prevalence of toxigenic in Vhembe, South Africa. Of 322 stool samples collected, toxigenic was found in 23 (7.1%) cases and was significantly associated with diarrhea 20 (11.4%) compared with 3 (2%) in non-diarrheal samples (χ = 426, = 0.001), intestinal inflammation in 18 (12.1%) compared with 5 (2.9%) in lactoferrin-negative samples (χ = 10.194, = 0.001), and occult blood in 19 (16%) compared with 4 (2%) in occult blood–negative samples (χ = 22.157, < 0.001). Toxigenic was more common among individuals > 50 years of age (20%), followed by those between 30 and 39 years of age (19%) and was not associated with HIV infections (χ = 0.289, = 0.591). Co-infection with other pathogens was common. Multivariate analysis indicated that toxigenic was associated with ( = 0.028), ( = 0.007), and Enteroaggregative (EAEC) ( = 0.007) in diarrheal samples. This study confirms the usefulness of PCR methodologies in the detection of toxigenic and suggests that is responsible for a small, but underappreciated, proportion of diarrheal cases in the region, and further study is warranted in this area.

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2008-04-01
2017-09-25
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  • Received : 06 Aug 2007
  • Accepted : 03 Jan 2008

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