1921
Volume 78, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We studied the serovar distribution of in patients with clinical eye disease in Western Australia. Most disease occurred in indigenous communities and was caused by trachoma serovars Ba and C. Serovar Ba was genetically homogeneous throughout Western Australia and identical to strains previously described in indigenous communities in Northern Territory. This finding probably results from movement of these populations, and suggests that a widely coordinated, rather than local or regional, approach is needed to control trachoma in mobile populations. Serovar C strains within Western Australia were homogeneous but distinct from those in Northern Territory, possibly because of inherent differences in transmissibility or differences in population movements among communities carrying the different serovars. Genital serovars were occasional causes of eye diseases in infants, adolescents, and adults in trachoma-endemic areas. These serovars should be considered in the differential diagnosis of acute follicular conjunctivitis in these groups.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2008.78.514
2008-03-01
2017-07-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/78/3/0780514.html?itemId=/content/journals/10.4269/ajtmh.2008.78.514&mimeType=html&fmt=ahah

References

  1. Taylor HR, 2001. Trachoma in Australia. Med J Aust 175 : 371–372.
  2. Kumaresan JA, Mecaskey JW, 2003. The global elimination of blinding trachoma: progress and promise. Am J Trop Med Hyg 69 (Suppl 5): 24–28.
  3. Mabey D, Solomon AW, 2003. Application of molecular tools in the control of blinding trachoma. Am J Trop Med Hyg 69 (Suppl 5): 11–17.
  4. Melese M, Chidambaran JD, Alemayehe W, Lee DC, Yi EH, Cevallos V, Zhou Z, Donnellan C, Saidel M, Whitcher JP, Gatnor BD, Leitman TM, 2004. Feasibility of eliminating ocular Chlamydia trachomatis with repeat mass antibiotic treatments. JAMA 292 : 721–724.
  5. Stevens MP, Tabrizi SN, Muller R, Krause V, Garland SM, 2004. Characterization of Chlamydia trachomatis omp1 genotypes detected in eye swab samples from remote Australian communities. J Clin Microbiol 42 : 2501–2507.
  6. Atthowe J, Giele C, Kwan K, Mak D, Trainor M, 2006. The Epidemiology of Notifiable Sexually Transmitted Infections and Blood-Borne Viruses in Western Australia 1995–2004. Accessed June 5, 2007. Available from http://www.population.health.wa.gov.au/Communicable/STIs_BBVs.cfm.
  7. Tullo AB, Richmond SJ, Easty DL, 1981. The presentation and incidence of paratrachoma in adults. J Hyg (Lond) 87 : 63–69.
  8. Mahoney JB, Luinstra KE, Sellors JW, Chernesky MA, 1993. Comparison of plasmid and chromosome based polymerase chain reaction assays for detecting Chlamydia trachomatis nucleic acids. J Clin Microbiol 31 : 1753–1758.
  9. Rodriguez P, Vekris A, Barbetrac BB, Dutilh B, Bonnet J, Bebear C, 1991. Typing of Chlamydia trachomatis by restriction endonuclease analysis of the amplified major outer membrane protein gene. J Clin Microbiol 29 : 1132–1136.
  10. Dean D, Millmen K, 1997. Molecular and mutation trends analyses of Omp1 alleles for serovar E of Chlamydia trachomatis. Implications for the immunopathogenesis of disease. J Clin Invest 99 : 475–483.
  11. Dean D, Stephens RS, 1994. Identification of individual genotypes of Chlamydia trachomatis from experimentally mixed serovars and mixed infections among trachoma patients. J Clin Microbiol 32 : 1506–1510.
  12. Mak DB, Smith DW, Harnett GB, Plant AJ, 2001. A large outbreak of conjunctivitis caused by a single genotype of Neisseria gonorrhoeae distinct from types causing genital tract infections. Epidemiol Infect 126 : 373–378.
  13. Hsieh Y, Bobo L, Quinn T, West S, 2001. Determinants of trachoma endemicity using C. trachomatis ompA DNA sequencing. Microbes Infect 3 : 447–458.
  14. Haynes LJ, Pecharatana S, Bailey RL, Hampton TJ, Pickett MA, Mabey DC, Watt PJ, Ward ME, 1995. Extent and kinetics of genetic change in the omp1 gene of Chlamydia trachomatis in two villages with endemic trachoma. J Infect Dis 172 : 268–272.
  15. Communicable Diseases Network of Australia, 2006. Guidelines for the Public Health Management of Trachoma in Australia. Accessed June 5, 2007. Available from http://www.health.gov.au/internet/wcms/publishing.nsf/Content/cda-cdna-pubs-trachoma.htm.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2008.78.514
Loading
/content/journals/10.4269/ajtmh.2008.78.514
Loading

Data & Media loading...

  • Received : 14 Jun 2007
  • Accepted : 14 Nov 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error