Volume 78, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


lineages, microsatellite allelic polymorphism, and mithocondrial gene haplotypes were directly typified from peripheral blood and cerebrospinal fluid specimens of a Bolivian patient with Chagas disease with accompanying AIDS and central nervous system severe involvement. Of note, the patient’s blood was infected by a mixture of I and IId/e polyclonal populations while the cerebrospinal fluid showed only a monoclonal I population. Our findings do not corroborate the original assumption of innocuity for I in the southern cone of the Americas and highlight lineage I tropism for central nervous system causing lethal Chagas reactivation.


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