1921
Volume 78, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Entomologic and serologic surveys were performed in four sentinel communities in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to . All communities have been receiving ivermectin mass treatment twice per year since 1997. In one community, parasite DNA was detected by polymerase chain reaction–enzyme-linked immunosorbent assay in 2004 in one pool of 50 vector heads of 170 such pools (8,500 flies) examined, which indicated an estimated transmission potential of 6.7 third-stage larvae/person/year. No evidence for transmission was found in the three other communities in 13,650 flies examined. All persons in a cohort consisting of 117 children in the four communities remained serologically negative for antibodies recognizing a cocktail of recombinant antigens over a four-year period from 2001 to 2004, which indicated an exposure incidence of 0%. Taken together, these data suggest that transmission has been suppressed in the four communities.

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2017-09-20
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References

  1. DadzieY, Neira M, Hopkins D. 2003. Final report of the conference on the eradicability of onchocerciasis. Filaria J 2:2.
  2. Vásquez-Castellanos JL, 1991. Cafeticultura e historia social de la oncocercosis en el Soconusco, estado de Chiapas, México. Salud Publica Mex 33 : 124–135.
  3. Rodríguez-Pérez MA, Lilley BG, Domínguez-Vázquez A, Segura-Arenas R, Lizarazo-Ortega C, Mendoza-Herrera A, Reyes-Villanueva F, Unnasch TR, 2004. Polymerase chain reaction monitoring of transmission of Onchocerca volvulus in two endemic states in Mexico. Am J Trop Med Hyg 70 : 38–45.
  4. Rodríguez-Pérez MA, Katholi CR, Hassan HK, Unnasch TR, 2006. Large-scale entomologic assessment of Onchocerca volvulus transmission by poolscreen PCR in Mexico. Am J Trop Med Hyg 74 : 1026–1033.
  5. World Health Organization, 1995. Onchocerciasis Control Programme in West Africa: Report of the World Health Organization for 1995. Geneva: World Health Organization. Mimeographed document OCP/JPC/16.2.
  6. Walsh JF, Davies JB, Le Berre LE, Garms R, 1978. Standardization of criteria for assessing the effects of Simulium control in onchocersiasis control programmes. Trans R Soc Trop Med Hyg 72 : 675–676.
  7. Rodríguez-Pérez MA, Rodríguez MH, Margeli-López HM, Rivas-Alcalá AR, 1995. Effect of semiannual treatments of ivermectin on the prevalence and intensity of Onchocerca volvulus skin infection, ocular lesions, and infectivity of Simulium ochraceum populations in southern Mexico. Am J Trop Med Hyg 52 : 429–434.
  8. Cupp EW, Ochoa JO, Collins RC, Cupp MS, Gonzales-Peralta C, Castro J, Zea-Flores G, 1992. The effects of repetitive community-wide ivermectin treatment on transmission of Onchocerca volvulus in Guatemala. Am J Trop Med Hyg 47 : 170–180.
  9. Grillet ME, Basáñez MG, Vivas-Martínez S, Villamizar N, Frontado H, Cortez J, Coronel P, Botto C, 2001. Human onchocerciasis in the Amazonian area of Southern Venezuela: spatial and temporal variations in biting and parity rates of black fly (Diptera: Simuliidae) vectors. J Med Entomol 38 : 520–530.
  10. Vieira JC, Brackenboro L, Porter CH, Basañez MG, Collins RC, 2005. Temporal and spatial variation in biting rates and parasite transmission potentials of onchocerciasis vectors in Ecuador. Trans R Soc Trop Med Hyg 99 : 178–195.
  11. Katholi CR, Toé L, Merriweather A, Unnasch TR, 1995. Determining the prevalence of Onchocerca volvulus infection in vector populations by PCR screening of pools of black flies. J Infect Dis 172 : 1414–1417.
  12. Lobos E, Altmann M, Mengod G, Weiss N, Rudin W, Karam M, 1990. Identification of an Onchocerca volvulus cDNA encoding low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera. Mol Biochem Parasitol 39 : 135–146.
  13. Lobos E, Weiss N, Karam M, Taylor HR, Ottesen EA, Nutman TB, 1991. An immunogenic Onchocerca volvulus antigen: a specific and early marker of infection. Science 251 : 1603–1605.
  14. Lustigman S, Brotman B, Johnson EL, Smith AB, Huima T, Prince AM, 1992. Identification and characterization of an Onchocerca volvulus cDNA clone encoding a microfilarial surface-associated antigen. Mol Biochem Parasitol 50 : 79–94.
  15. Rodríguez-Pérez MA, Danis-Lozano R, Rodríguez MH, Bradley JE, 1999. Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. Trop Med Int Health 4 : 98–104.
  16. Bradley JE, Gillespie AJ, Trenholme KR, Karam M, 1993a. The effects of vector control on the antibody response to antigens of Onchocerca volvulus. Parasitology 106 : 363–370.
  17. Tree TI, Gillepsie AJ, Shepley KJ, Blaxter ML, Tuan RS, Bradley JE, 1995. Characterisation of an immunodominant glycoprotein antigen of Onchocerca volvulus with holomologues in other filarial nematodes and Caenorhabditis elegans. Mol Biochem Parasitol 69 : 185–195.
  18. Bloch P, Simonsen PE, Weiss N, Nutman TB, 1998. The significance of guinea worm infection in the immunological diagnosis of onchocerciasis and bancroftian filariasis. Trans R Soc Trop Med Hyg 92 : 518–521.
  19. Bradley JE, Trenholme KR, Gillespie AJ, Guderian R, Titanji V, Hong Y, McReynolds LA, 1993b. A sensitive serodiagnostic test for onchocerciasis using a cocktail of recombinant antigens. Am J Trop Med Hyg 48 : 198–204.
  20. Rodríguez-Pérez MA, Domínguez-Vásquez A, Méndez-Galván J, Sifuentes-Rincón AM, Larralde-Corona P, Barrera-Saldaña HA, Bradley JE, 2003. Antibody detection tests for Onchocerca volvulus: comparison of the sensitivity of a cocktail of recombinant antigens used in the indirect enzyme-linked immunosorbent assay with a rapid-format antibody card test. Trans R Soc Trop Med Hyg 97 : 539–541.
  21. Martin-Tellaeche A, Ramirez-Hernandez J, Santos-Preciado JI, Mendez-Galvan J, 1998. Onchocerciasis: changes in transmisión in Mexico. Ann Trop Med Parasitol 92 : S117–S119.
  22. Williams CB, 1937. The use of logarithms in the interpretation of certain entomological problems. Ann Appl Biol 24 : 404–414.
  23. World Health Organization, 2001. Certification of Elimination of Human Onchocerciasis: Criteria and Procedures. Geneva: World Health Organization.
  24. Femandez-Salas I, Roberts DR, Rodriguez MH, Marina-Fernandez CE, 1994. Bionomics of larval populations of Anopheles pseudopunctipennis in the Tapachula foothills area, southern Mexico. J Am Mosq Control Assoc 10 : 477–486.
  25. Kirkwood BR, Sterne AC, 2003. Essential Medical Statistics. Second edition. Oxford, United Kingdom: Blackwell Science Ltd.
  26. Kotz S, Johnson NL, Read CB, 1988. Method of statistical differentials. Encyclopedia of Statistical Sciences. Volume 8. New York: Wiley, 646–666.
  27. Grillet ME, Basañez MG, Vivas-Martínez S, Villamizar N, Frontado H, Cortez J, Coronel P, Botto C, 2001. Human onchocerciasis in the Amazonian area of the southern Venezuela: spatial and temporal variations in biting and parity rates of black fly (Diptera: Simuliidae) vectors. J Med Entomol 38 : 520–530.
  28. Duerr HP, Dietz K, Eichner M, 2005. Determinants of the eradicability of filarial infections: a conceptual approach. Trends Parasiltol. 21 : 88–96.
  29. Basañez MG, Rodríguez D, 2004. Dinámica de transmisión y modelos matemáticos en enfermedades transmitidas por vectores. Entomotropica 19 : 113–134.
  30. Lindblade KA, Arana B, Zea-Flores G, Rizzo N, Porter CH, Dominguez-Vasquez A, Cruz-Ortiz N, Unnasch TR, Punkosdy GA, Richards J, Sauerbrey M, Castro J, Catú E, Oliva O, Richards FO, 2007. Eradication of Onchocerca volvulus transmission in the Santa Rosa focus of Guatemala. Am J Trop Med Hyg 77 : 334–341.
  31. Pardo R, 1927. A Propósito de los ciegos de Tiltepec. Gac Med Mex 58 : 195.
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  • Received : 17 May 2007
  • Accepted : 09 Oct 2007

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