Volume 78, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Penicilliosis marneffei, which is caused by the opportunistic fungus , is one of the troublesome infections in patients infected with human immunodeficiency virus (HIV) in southeast Asia. We report an HIV-positive patient with acute disseminated penicilliosis marneffei that manifested as hemophagocytic syndrome. Numerous nucleated erythrocytes were also found in peripheral blood of the affected patient. Bone marrow aspirate histopathologically showed hemophagocytosis and abundant . The hemophagocytic syndrome and peripheral nucleated erythrocytes improved after therapy with amphotericin B. Our report underscores the importance of recognition of this peculiar phenomenon in penicilliosis marneffei. This awareness may alert clinicians to potential penicilliosis marneffei in HIV-positive patients, therefore making early diagnosis and timely effective treatment of the infectious disease possible.


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  1. Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T, 1994. Disseminated Penicillium marneffei infection in southeast Asia. Lancet 344 : 110–113. [Google Scholar]
  2. Hsueh PR, Teng LJ, Hung CC, Hsu JH, Yang PC, Ho SW, Luh KT, 2000. Molecular evidence for strain dissemination of Penicillium marneffei: an emerging pathogen in Taiwan. J Infect Dis 181 : 1706–1712. [Google Scholar]
  3. Hung CC, Hsueh PR, Chen MY, Hsiao CH, Chang SC, Luh KT, 1998. Invasive infection caused by Penicillium marneffei: an emerging pathogen in Taiwan. Clin Infect Dis 26 : 202–203. [Google Scholar]
  4. Sirisanthana T, Supparatpinyo K, Perriens J, Nelson KE, 1998. Amphotericin B and itraconazole for treatment of disseminated Penicillium marneffei infection in human immunodeficiency virus-infected patients. Clin Infect Dis 26 : 1107–1110. [Google Scholar]
  5. Fisman DN, 2000. Hemophagocytic syndromes and infection. Emerg Infect Dis 6 : 601–608. [Google Scholar]
  6. Chim CS, Fong CY, Ma SK, Wong SS, Yuen KY, 1998. Reactive hemophagocytic syndrome associated with Penicillium marneffei infection. Am J Med 104 : 196–197. [Google Scholar]
  7. Wong SSY, Wong KH, Hui WT, Lee SS, Lo JYC, Cao L, Yuen KY, 2001. Differences in clinical and laboratory diagnostic characteristics of Penicilliosis marneffei in human immunodeficiency virus (HIV) and non-HIV-infected patients. J Clin Microbiol 39 : 4535–4540. [Google Scholar]
  8. Erslev AJ, 2001. Anemia associated with marrow infiltration. Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U. eds. Williams Hematology. 6th edition. San Diego: McGraw-Hill, 477–478.
  9. Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T, 2006. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev 19 : 95–110. [Google Scholar]
  10. Khor BS, Liu JW, Leu HS, 2005. Rapid fatality of disseminated Penicilliosis marneffei in a patient with acquired immunodeficiency syndrome. Infect Dis Clin Pract 13 : 90–91. [Google Scholar]
  11. Liu JW, Huang TC, Lu YC, Liu HT, Li CC, Wu JJ, Lin JW, Chen WJ, 1999. Acute disseminated histoplasmosis complicated with hypercalcaemia. J Infect 39 : 88–90. [Google Scholar]
  12. Lai CH, Huang CK, Chin C, Yang YT, Lin HF, Lin HH, 2007. Indigenous case of disseminated histoplasmosis, Taiwan. Emerg Infect Dis 13 : 127–129. [Google Scholar]
  13. Mootsikapun P, Srikulbutr S, 2006. Histoplasmosis and penicilliosis: comparison of clinical features, laboratory findings and outcome. Int J Infect Dis 10 : 66–71. [Google Scholar]
  14. Liu MT, Wong CK, Fung CP, 1994. Disseminated Penicillium marneffei infection with cutaneous lesions in an HIV-positive patient. Br J Dermatol 131 : 280–283. [Google Scholar]
  15. Antinori S, Gianelli E, Bonaccorso C, Ridolfo AL, Croce F, Sollima S, Parravicini C, 2006. Disseminated Penicillium marneffei infection in an HIV-positive Italian patient and a review of cases reported outside endemic regions. J Travel Med 13 : 181–188. [Google Scholar]
  16. Sirisanthana T, Supparatpinyo K, 1998. Epidemiology and management of penicilliosis in human immunodeficiency virus-infected patients. Int J Infect Dis 3 : 48–53. [Google Scholar]

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  • Received : 10 Sep 2007
  • Accepted : 09 Oct 2007

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