1921
Volume 78, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The aim of this work was to study the prevalence of hepatitis E virus (HEV) and the risk factors for the acquisition of the virus in a population in contact with swine and unexposed to swine. A total of 198 individuals, 97 unexposed (49%) and 101 exposed (51%) to swine, were tested for the presence of HEV infection. The prevalence of anti-HEV IgG in the exposed group was 18.8% versus 4.1% in the unexposed to swine group. People exposed to swine were observed to be 5.4 times ( = 0.03) at risk of having anti-HEV IgG. Ten (52.6%) of the IgG-positive individuals showed two concomitant risk factors: untreated water consumption and exposure to swine. These data support that HEV infection should be treated as a vocational illness in swine workers. Therefore, systematic application of hygiene measures in this collective is highly recommended to avoid the exposition to this virus.

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2008-06-01
2017-09-23
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References

  1. Perez-Gracia MT, Rodriguez-Iglesias M, 2003. [Hepatitis E virus: current status]. Med Clin (Barc) 121 : 787–792.
  2. Schlauder GG, Dawson GJ, Erker JC, Kwo PY, Knigge MF, Smalley DL, Rosenblatt JE, Desai SM, Mushahwar IK, 1998. The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States. J Gen Virol 79 : 447–456.
  3. Meng XJ, Halbur PG, Shapiro MS, Govindarajan S, Bruna JD, Mushahwar IK, Purcell RH, Emerson SU, 1998. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 72 : 9714–9721.
  4. Aggarwal R, Krawczynski K, 2000. Hepatitis E: an overview and recent advances in clinical and laboratory research. J Gastroenterol Hepatol 15 : 9–20.
  5. Perez-Gracia MT, Garcia-Valdivia MS, Galan F, Rodriguez-Iglesias MA, 2004. Detection of hepatitis E virus in patients sera in southern Spain. Acta Virol 48 : 197–200.
  6. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, Emerson SU, Purcell RH, 2002. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol 40 : 117–122.
  7. Withers MR, Correa MT, Morrow M, Stebbins ME, Seriwatana J, Webster WD, Boak MB, Vaughn DW, 2002. Antibody levels to hepatitis E virus in North Carolina swine workers, non-swine workers, swine, and murids. Am J Trop Med Hyg 66 : 384–388.
  8. Bouwknegt M, Engel B, Herremans MM, Widdowson MA, Worm HC, Koopmans MP, Frankena K, Husman AM, De Jong MC, Der Poel WH, 2007. Bayesian estimation of hepatitis E virus seroprevalence for populations with different exposure levels to swine in The Netherlands. Epidemiol Infect 136 : 1–10.
  9. Drobeniuc J, Favorov MO, Shapiro CN, Bell BP, Mast EE, Dadu A, Culver D, Iarovoi P, Robertson BH, Margolis HS, 2001. Hepatitis E virus antibody prevalence among persons who work with swine. J Infect Dis 184 : 1594–1597.
  10. Hsieh SY, Meng XJ, Wu YH, Liu ST, Tam AW, Lin DY, Liaw YF, 1999. Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J Clin Microbiol 37 : 3828–3834.
  11. Olsen B, Axelsson-Olsson D, Thelin A, Weiland O, 2006. Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls. Scand J Infect Dis 38 : 55–58.
  12. Vulcano A, Angelucci M, Candelori E, Martini V, Patti AM, 2007. HEV prevalence in the general population and among workers at zoonotic risk in Latium Region. Ann Ig 19 : 181–186.
  13. Huang FF, Haqshenas G, Guenette DK, Halbur PG, Schommer SK, Pierson FW, Toth TE, Meng XJ, 2002. Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States. J Clin Microbiol 40 : 1326–1332.
  14. Fernandez-Barredo S, Galiana C, Garcia A, Vega S, Gomez MT, Perez-Gracia MT, 2006. Detection of hepatitis E virus shedding in feces of pigs at different stages of production using reverse transcription-polymerase chain reaction. J Vet Diagn Invest 18 : 462–465.
  15. Amon JJ, Drobeniuc J, Bower WA, Magana JC, Escobedo MA, Williams IT, Bell BP, Armstrong GL, 2006. Locally acquired hepatitis E virus infection, El Paso, Texas. J Med Virol 78 : 741–746.
  16. Perez-Gracia MT, Mateos ML, Galiana C, Fernández-Barredo S, García A, Goméz MT, Moreira V, 2007. Autochthonous hepatitis E infection in a slaughterhouse worker. Am J Trop Med Hyg 77 : 893–896.
  17. Mizuo H, Yazaki Y, Sugawara K, Tsuda F, Takahashi M, Nishizawa T, Okamoto H, 2005. Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan. J Med Virol 76 : 341–349.
  18. Fernandez-Barredo S, Galiana C, Garcia A, Gomez-Munoz MT, Vega S, Rodriguez-Iglesias MA, Perez-Gracia MT, 2007. Prevalence and genetic characterization of hepatitis E virus in paired samples of feces and serum from naturally infected pigs. Can J Vet Res 71 : 236–240.
  19. Dalton HR, Thurairajah PH, Fellows HJ, Hussaini HS, Mitchell J, Bendall R, Banks M, Ijaz S, Teo CG, Levine DF, 2007. Autochthonous hepatitis E in southwest England. J Viral Hepat 14 : 304–309.
  20. Herremans M, Bakker J, Duizer E, Vennema H, Koopmans MP, 2007. Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity. Clin Vaccine Immunol 14 : 562–568.
  21. Gessoni G, Manoni F, 1996. Hepatitis E virus infection in northeast Italy: serological study in the open population and groups at risk. J Viral Hepat 3 : 197–202.
  22. Boutrouille A, Bakkali-Kassimi L, Cruciere C, Pavio N, 2007. Prevalence of anti-hepatitis E virus antibodies in French blood donors. J Clin Microbiol 45 : 2009–2010.
  23. Dalton HR, Fellows HJ, Gane EJ, Wong P, Gerred S, Schroeder B, Croxson MC, Garkavenko O, 2007. Hepatitis E in New Zealand. J Gastroenterol Hepatol 22 : 1236–1240.
  24. Bortoliero AL, Bonametti AM, Morimoto HK, Matsuo T, Reiche EM, 2006. Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Parana, Brazil. Rev Inst Med Trop Sao Paulo 48 : 87–92.
  25. Mateos ML, Camarero C, Lasa E, Teruel JL, Mir N, Baquero F, 1998. Hepatitis E virus: relevance in blood donors and other risk groups. Vox Sang 75 : 267–269.
  26. Buti M, Dominguez A, Plans P, Jardi R, Schaper M, Espunes J, Cardenosa N, Rodriguez-Frias F, Esteban R, Plasencia A, Salleras L, 2006. Community-based seroepidemiological survey of hepatitis E virus infection in Catalonia, Spain. Clin Vaccine Immunol 13 : 1328–1332.
  27. Boxall E, Herborn A, Kochethu G, Pratt G, Adams D, Ijaz S, Teo CG, 2006. Transfusion-transmitted hepatitis E in a nonhyper- ‘ endemic’ country. Transfusion Med 16 : 79–83.
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  • Received : 16 Oct 2007
  • Accepted : 03 Jan 2008

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