Volume 77, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Endosymbionic bacteria inside adult worms (causing river blindness) are necessary for female worm fertility. We evaluated whether rifampin and/or azithromycin used in a five-day course could kill In an open-label trial in Guatemala, 73 patients with 134 palpable onchocercal nodules were randomized into four treatment groups: rifampin, azithromycin, a combination of the two drugs, and controls (multivitamins). After five days of antibiotic treatment, all participants received a single dose of ivermectin on day 6. Nine months after treatment, the nodules were removed and the worms were examined. Skin snips to determine microfilariae were obtained at baseline and nine months. There were no significant differences between any of the treatment groups in the condition of the worms in the nodules, the presence of surface protein, or the number of microfilariae in skin. Short courses with these antibiotics will not clear from .


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  • Received : 20 Jul 2007
  • Accepted : 02 Aug 2007

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