1921
Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The objective of this cross-sectional study was to assess the use of traditional herbal medicine by AIDS patients in Kabarole District, western Uganda. Using systematic sampling, 137 AIDS patients were selected from outpatient departments of 3 hospitals and interviewed via questionnaire. The questions related to such areas as type and frequency of herbal medicine intake, concomitant herb–pharmaceutical drug use (including herb–antiretroviral drug cotherapy), and the perceived effectiveness of herbal medicine. Overall, 63.5% of AIDS patients had used herbal medicine after HIV diagnosis. Same-day herbal medicine and pharmaceutical drugs use was reported by 32.8% of AIDS patients. Patterns of traditional herbal medicine use were quite similar between those on antiretroviral therapy and those who received supportive therapy only. The primary conclusion is that AIDS outpatients commonly use herbal medicine for the treatment of HIV/AIDS. Pharmacological interactions between antiretroviral drugs and traditional herbal medicines need to be further examined.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2007.77.757
2007-10-01
2017-09-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/77/4/0770757.html?itemId=/content/journals/10.4269/ajtmh.2007.77.757&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2002. WHO Traditional Medicine Strategy 2002–2005. Geneva, Switzerland: WHO.
  2. Pecoul B, Chirac P, Trouiller P, Pinel J, 1999. Access to essential drugs in poor countries: a lost battle? JAMA 281 : 361–367.
  3. Sebit MB, Chandiwana SK, Latif AS, Gomo E, Acuda SW, Makoni F, Vushe J, 2002. Neuropsychiatric aspects of HIV disease progression: impact of traditional herbs on adult patients in Zimbabwe. Prog Neuropsychopharmacol Biol Psychiatry 26 : 451–456.
  4. Giarelli E, Jacobs LA, 2001. HIV/AIDS in KwaZulu-Natal, South Africa: an interview with Dr. Leana Uys. J Assoc Nurses AIDS Care 12 : 52–67.
  5. Bodeker G, Kabatesi D, King R, Homsy J, 2000. A regional task force on traditional medicine and AIDS. Lancet 355 : 1284.
  6. King R, Homsy J, 1997. Involving traditional healers in AIDS education and counselling in sub-Saharan Africa: a review. AIDS 11 (Suppl A): S217–S225.
  7. Mills E, Foster BC, van Heeswijk R, Phillips E, Wilson K, Leonard B, Kosuge K, Kanfer I, 2005. Impact of African herbal medicine on antiretroviral metabolism. AIDS 19 : 95–96.
  8. Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J, 2002. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 34 : 234–238.
  9. Piscitelli SC, Burstein AH, Chaitt D, Alfaro RM, Falloon J, 2000. Indinavir concentrations and St. John’s wort. Lancet 255 : 547–548.
  10. Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, Del Giudice P, Montagne N, Schapiro JM, Dellamonica P, 2000. Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study. AIDS 14 : 1333–1339.
  11. World Health Organization, 2003. Fact Sheet No. 134: Traditional medicine. Geneva, Switzerland: WHO. Available at: http://www.who.int/mediacentre/factsheets/2003/fsl134/en/print.html. Accessed January 25, 2004.
  12. World Health Organization, 2005. Progress on Global Access to HIV Antiretroviral Therapy: An Update on “3 by 5”. Geneva, Switzerland: WHO.
  13. World Health Organization, 2005. Summary Country Profile for HIV/AIDS Treatment Scale-up: Uganda. Geneva, Switzerland: WHO. Available at: http://www.who.int/3by5/support/june2005_uga.pdf. Accessed December 11, 2005.
  14. Bodeker G, 2003. Traditional medicine. In G. Cook, A. Zumla, eds. Manson’s Tropical Disease. Twenty-first edition. London: W.B. Saunders, 33–48.
  15. Burford G, Bodeker G, Kabatesi D, Gemmill B, Rukangira E, 2000. Traditional medicine and HIV/AIDS in Africa: a report from the international conference on medicinal plants, traditional medicine and local communities in Africa (a parallel session to the Fifth Conference of the Parties to the Convention of Biological Diversity, Nairobi, Kenya, May 16–19, 2000). J Altern Complement Med 6 : 457–471.
  16. Brinkhoff T, 2006. Thomas Brinkhoff: City Population. Available at: http://www.citypopulation.de/Uganda.html. Accessed April 19, 2006.
  17. Uganda District Information Handbook, 2002–2006, Fountain Publishers, Kampala, Uganda, 2005, p. Thomas Brinkhoff: City Population. Available at: http://www.citypopulation.de/Uganda.html. Accessed April 19156.
  18. Bica I, Tang AM, Skinner S, Spiegelman D, Knox T, Gorbach S, Wilson IB, 2003. Use of complementary and alternative therapies by patients with human immunodeficiency virus disease in the era of highly active anti-retroviral therapy. J Altern Complement Med 9 : 65–76.
  19. Furler MD, Einarson TR, Walmsley S, Millson M, Bendayan R, 2003. Use of complementary and alternative medicine by HIV-infected outpatients in Ontario, Canada. AIDS Patient Care 17 : 155–168.
  20. Geissler PW, Harris SA, Prince RJ, Olsen A, Achieng’ Odhiambo R, Oketch-Rabah H, Madiega PA, Andersen A, Molgaard P, 2002. Medicinal plants used by Luo mothers and children in Bondo district, Kenya. J Ethnopharmacol 83 : 39–54.
  21. Eisenberg DM, Kessler RC, Van Rompay MI, Kaptchuk TJ, Wilkey SA, Appel S, Davis RB, 2001. Perceptions about complementary therapies relative to conventional therapies among adults who use both: results from a national survey. Ann Intern Med 135 : 344–351.
  22. Prince RJ, Geissler W, Nokes K, Maende JO, Okatcha F, Gringorenko E, Sternberg R, 2001. Knowledge of herbal and pharmaceutical medicines among Luo children in western Kenya. Anthropol Med 8 : 211–235.
  23. Astin JA, 1998. Why patients use alternative medicine: results of a national study. JAMA 279 : 1548–1553.
  24. Morris K, 2001. Treating HIV in South Africa—a tale of two systems. Lancet 357 : 1190.
  25. SPSS, 2002. Statistical Package for the Social Sciences, Version 11.5.1. Chicago, IL: SPSS Inc.
  26. UNAIDS, Joint United Nations Programme on HIV/AIDS, 2000. Collaboration with Traditional Healers in HIV/AIDS Prevention and Care in Sub-Saharan Africa: A Literature Review. Available at: http://www.unaids.org/html/pub/publications/irc-pub01/jc299-tradheal_en_pdf.pdf. Accessed June 4, 2004.
  27. Homsy J, Katabira E, Kabatesi D, Mubiru F, Kwamya L, Tusaba C, Kasolo S, Mwebe D, Ssentamu L, Okello M, King R, 1999. Evaluating herbal medicine for the management of herpes zoster in human immunodeficiency virus-infected patients in Kampala, Uganda. J Alternat Complement Med 5 : 553–565.
  28. Hamill FA, Apio S, Mubiru NK, Mosango M, Bukenya-Ziraba R, Maganyi OW, Soejarto DD, 2000. Traditional herbal drugs of southern Uganda, I. J Ethnopharmacol 70 : 281–300.
  29. Geissler PW, Nokes K, Prince RJ, Achieng’ Odhiambo R, Aa-gaard-Hansen J, Ouma JH, 2000. Children and medicines: self-treatment of common illnesses among Luo schoolchildren in western Kenya. Soc Sci Med 50 : 1771–1783.
  30. Tsey K, 1997. Traditional medicine in contemporary Ghana: a public policy analysis. Soc Sci Med 45 : 1065–1074.
  31. Manfredi R, Chiodo F, 2000. The effects of alternative treatments for HIV disease on recommended pharmacological regimens. Int J Antimicrob Agents 13 : 281–285.
  32. Chang BL, Van Servellen G, Lombardi E, 2003. Factors associated with complementary therapy use in people living with HIV/AIDS receiving anti-retroviral therapy. J Altern Complement Med 9 : 695–710.
  33. Sparber A, Wootton JC, Bauer L, Curt G, Eisenberg D, Levin T, Steinberg SM, 2000. Use of complementary medicine by adult patients participating in HIV/AIDS clinical trials. J Altern Complement Med 6 : 415–422.
  34. Ostrow MJ, Cornelisse PGA, Heath KV, Craib KJP, Schechter MT, O’Shaughnessy J, Montaner JSG, Hogg RS, 1997. Determinants of complementary therapy use in HIV-infected individuals receiving anti-retroviral or anti-opportunistic agents. J Acquir Immune Defic Syndr Hum Retrovirol 15 : 115–120.
  35. Langewitz W, Ruttimann S, Laifer G, Maurer P, Kiss A, 1994. The integration of alternative treatment modalities in HIV infection—the patient’s perspective. J Psychosom Res 38 : 687–693.
  36. Rafatro H, Ramanitrahasimbola D, Rasoanaivo P, Ratsimamanga-Urverg S, Rakoto-Ratsimamanga A, Frappier F, 2000. Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria. Biochem Pharmacol 59 : 1053–1061.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.77.757
Loading
/content/journals/10.4269/ajtmh.2007.77.757
Loading

Data & Media loading...

  • Received : 22 Feb 2007
  • Accepted : 19 Jun 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error