1921
Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

This community-based study evaluated the role of aflatoxin exposure in advanced liver disease in hepatitis C virus (HCV)-endemic townships. Preventive health examination was performed on 314 adults ≥ 40 years of age recruited from HCV-endemic townships in Tainan, Taiwan. Aflatoxin-albumin in serum was quantified by a new enzyme-linked immunosorbent assay method. After adjusting serum albumin levels and platelet counts, aflatoxin-Bi albumin adducts was still an independent risk factor for advanced liver disease among all 314 residents (> 8 versus ≤ 8 (AFBi)-albumin/albumin; OR = 2.29, 95% CI = 1.23–4.27, = 0.009) and particularly in anti-HCV-positive subjects (OR = 2.09, 95% CI = 1.09–4.0, = 0.026). Levels of AFB1-albumin/albumin were significantly related to ultrasonographic parenchyma scores ( < 0.001, one-way ANOVA) in all and anti-HCV–positive subjects. The findings indicated aflatoxin exposure may be associated with advanced liver disease in chronic hepatitis C patients in HCV-endemic regions in Taiwan.

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2007-10-01
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  • Received : 20 Feb 2007
  • Accepted : 27 Jul 2007

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