Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


and helminth infections coincide geographically and are classically described as TH1 and TH2 pathologies. There is much interest in exploring how concurrent worm infections might alter immune responses to mycobacterial infection. To explore this issue, mice were infected with and co-infected with . Mice infected with had high numbers of neutrophils and mononuclear cells within the alveolar spaces, with increased parenchymal interferon (IFN)-γ levels. However, in -infected mice we detected increased eosinophil numbers in bronchoalveolar lavage fluid (BALF) and increased parenchymal levels of interleukin (IL)-5. In co-infected mice the BALF demonstrated enhanced eosinophil influx with decreased neutrophil and mononuclear cell accumulation. However, co-infected mice had similar mycobacterial proliferation in their lungs accompanied by similar histopathological changes and similar cytokine/nitric oxide production compared with -only–infected mice. Our results suggest that infection does not necessarily lead to increased susceptibility to pulmonary tuberculosis.


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  • Received : 19 Jan 2007
  • Accepted : 22 May 2007

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