1921
Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

In vitro trypanocidal and leishmanicidal activities of the flavonoids hispidulin, from , and santin, from , are reported. A sensitive technique that takes advantage of (H)thymidine uptake by dividing trypanosomatids has been adjusted for quantification of the parasiticidal effect of the natural products. The IC values for hispidulin and santin on epimastigotes were 46.7 and 47.4 μM, respectively. On trypomastigotes, the IC values were 62.3 μM for hispidulin and 42.1 μM for santin. Hispidulin was more active than santin on promastigotes of (IC = 6.0 μM versus 32.5 μM). No cytotoxic activity was observed on lymphoid cells, making hispidulin and santin potential lead compounds for the development of new natural drugs. This is the first report on the trypanocidal and leishmanicidal activities of these flavonoids and on the presence of santin in .

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2007-10-01
2017-11-24
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  • Received : 08 Jan 2007
  • Accepted : 17 Jun 2007

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