1921
Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A comprehensive medical evaluation to identify persistent and untreated tropical infections among members of the Sudanese group “Lost Boys of Sudan” living in Atlanta, GA, was initiated. Medical examinations and laboratory testing including blood cell counts, liver function tests, stool studies for parasites, hepatitis B serologies, and serologic testing for spp., and filariae were performed. Preliminary results showed a high prevalence of untreated active schistosomiasis and strongyloidiasis infections in this group, 5 years after their resettlement in the United States. In addition, we found that many of them were infected with onchocerciasis and hepatitis B. We suggest that based on these preliminary results, pre-departure presumptive treatment and/or testing algorithms need to address some of these persistent tropical infections.

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2007-10-01
2017-09-25
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References

  1. Adams KM, Gardiner LD, Assefi N, 2004. Healthcare challenges from the developing world: post-immigration refugee medicine. BMJ 328 : 1548–1552.
  2. Centers for Disease Control and Prevention, 2005. Recommendations for Presumptive Treatment of Schistosomiasis and Strongyloidiasis Among the Somali Bantu Refugees. Atlanta, GA: CDC, Division of Global Migration and Quarantine.
  3. Centers for Disease Control and Prevention, 2005. Recommendations for Presumptive Treatment of Schistosomiasis and Strongyloidiasis Among the Lost Boys and Girls of Sudan. Atlanta, GA: CDC, Division of Global Migration and Quarantine.
  4. Scientific Working Group on Serious Adverse Events in, 2003. Loa loa endemic areas. Report of a Scientific Working Group on Serious Adverse Events following Mectizan (R) treatment of onchocerciasis in Loa loa endemic areas. J Filaria 24 (Suppl 1): S2.
  5. Klion AD, Massougbodji A, Sadeler BC, Ottesen EA, Nutman TB, 1991. Loaisis in endemic and nonendemic populations: immunologically mediated differences in clinical presentation. J Infect Dis 163 : 1318–1325.
  6. Twum-Danso NA, 2003. Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future. J Filaria 24 (Suppl 1): S7.
  7. Tsang VCW, Wilkins PP, 1997. Immunodiagnosis of schistosomiasis. Immunol Investig 26 : 175–188.
  8. Cetron MS, Chitsulo L, Sullivan JJ, Pilcher J, Wilson M, Noh J, Tsang VC, Hightower AW, Addiss DG, 1996. Schistosomiasis in Lake Malawi. Lancet 348 : 1274–1278.
  9. Al-Sherbiny MM, Osman AM, Hancock K, Deelder AM, Tsang VCW, 1999. Application of immunodiagnostic assays: detection of antibodies and circulating antigens in human schistosomiasis and correlation with clinical findings. Am J Trop Med Hyg 60 : 960–966.
  10. Loufty MR, Wilson M, Keystone J, Kain KC, 2002. Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area. Am J Trop Med Hyg 66 : 749–752.
  11. Lal RB, Ottesen EA, 1988. Enhanced diagnostic specificity in human filariasis by IgG4 antibody assessment. J Infect Dis 158 : 1034.
  12. Kwan-Lim GE, Forsyth KP, Maizels RM, 1990. Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection. J Immunol 145 : 4298.
  13. Drugs for parasitic infections, 2004. Medical Letter 46 : 1–12.
  14. Geltman PL, Cochran J, Hedgecock C, 2003. Intestinal parasites among African refugees resettled in Massachusetts and the impact of an overseas pre-departure treatment program. Am J Trop Med Hyg 69 : 657–662.
  15. U.S. Committee for Refugees and Immigrants. World Refugee Survey 2007. Available at http://www.refugees.org/countryreports.aspx?id=208.
  16. Garg PK, Perry S, Dorn M, Hardcastle L, Parsonnet J, 2005. Risk of intestinal helminth and protozoan infection in a refugee population. Am J Trop Med Hyg 73 : 386–391.
  17. Muennig P, Pallin D, Sell RL, Man-Suen C, 1999. The cost effectiveness of strategies for the treatment of intestinal parasites in immigrants. N Engl J Med 340 : 773–779.
  18. Miller JM, Boyd HA, Ostrowski SR, Cookson ST, Parise ME, Gonzaga PS, Addiss DG, Wilson M, Nguyen-Dinh P, Wahlquist SP, Weld LH, Wainwright RB, Gushulak BD, Cetron MS, 2000. Malaria, intestinal parasites, and schistosomiasis among Barawan Somali refugees resettling to the United States: a strategy to reduce morbidity and decrease the risk of imported infections. Am J Trop Med Hyg 62 : 115–121.
  19. Geltman PL, Cochran J, 2005. A private-sector preferred provider network model for public health screening of newly resettled refugees. Am J Public Health 95 : 196–199.
  20. Stauffer WM, Kamat D, Walker PF, 2002. Screening of international immigrants, refugees, and adoptees. Prim Care Clin Offic Pract 29 : 879–905.
  21. Barnett ED, 2004. Infectious disease screening for refugees resettled in the United States. Clin Infect Dis 39 : 833–841.
  22. Seybolt LM, Christiansen D, Barnett ED, 2006. Diagnostic evaluation of newly arrived asymptomatic refugees with eosinophilia. Clin Infect Dis 42 : 363–367.
  23. Newberry AM, Williams DN, Stauffer WM, Boulware DR, Hendel-Paterson BR, Walker PF, 2005. Strongyloides hyperinfection presenting as acute respiratory failure and gram negative sepsis. Chest 128 : 3681–3684.
  24. Summer AP, Stauffer W, Maroushek ST, Nevins TE, 2006. Hematuria in children due to schistosomiasis in a nonendemic setting. Clin Pediatr 45 : 177–181.
  25. Lim S, Katz K, Krajden S, Fuksa M, Keystone JS, Kain KC, 2004. Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. Can Med Assoc J 171 : 479–484.
  26. Centers for Disease Control and Prevention, 1991. Screening for hepatitis B virus infection among refugees arriving in the United States, 1979–1991. Mortal Morbid Wkly Rev 40 : 784–786.
  27. Aquino RT, Chieffi PP, Catunda SM, Araújo MF, Ribeiro MC, Taddeo EF, Rolim EG, 2000. Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis. Rev Inst Med Trop Sao Paulo 42 : 313–320.
  28. Lal RB, Ottessen EA, 1998. Enhanced diagnostic specificity in human filariasis by IgG4 antibody assessment. J Infect Dis 158 : 1034.
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  • Received : 20 Mar 2007
  • Accepted : 18 Jun 2007

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