1921
Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of malaria in Ghana. Urinary hepcidin was semi-quantitatively assessed using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Urinary hepcidin (intensity/mmol creatinine) was associated with log parasitemia in 86 children (beta = 0.086, standard error [SE] = 0.035, < 0.017), 31 pregnant women (beta = 0.218, SE = 0.085, < 0.016), and 82 adults (beta = 0.184, SE =0.043, < 0.0001). Urinary hepcidin was not significantly associated with hemoglobin or anemia. Urinary hepcidin is more strongly associated with parasitemia than hemoglobin or anemia among patients with acute malaria in Ghana.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2007.77.623
2007-10-01
2018-12-17
Loading full text...

Full text loading...

/deliver/fulltext/14761645/77/4/0770623.html?itemId=/content/journals/10.4269/ajtmh.2007.77.623&mimeType=html&fmt=ahah

References

  1. Guinovart C, Navia MM, Tanner M, Alonso PL, 2006. Malaria: burden of disease. Curr Mol Med 6 : 137–140. [Google Scholar]
  2. Ganz T, 2005. Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 18 : 171–182. [Google Scholar]
  3. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loréal O, 2001. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276 : 7811–7819. [Google Scholar]
  4. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S, 2002. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 : 1037–1044. [Google Scholar]
  5. Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC, 2002. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 : 3776–3781. [Google Scholar]
  6. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D, 2005. Novel urine hepcidin assay by mass spectrometry. Blood 106 : 3268–3270. [Google Scholar]
  7. World Health Organization, 1968. Nutritional Anemia: Report of a WHO Scientific Group. Geneva, Switzerland: World Health Organization.
  8. Roy CN, Andrews NC, 2005. Anemia of inflammation: the hepcidin link. Curr Opin Hematol 12 : 107–111. [Google Scholar]
  9. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T, 2004. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Investig 113 : 1271–1276. [Google Scholar]
  10. McDevitt MA, Xie J, Gordeuk V, Bucala R, 2004. The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep 3 : 97–106. [Google Scholar]
  11. Anderson GJ, Frazer DM, Wilkins SJ, Becker EM, Millard KN, Murphy TL, McKie AT, Vulpe CD, 2002. Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans 30 : 724–726. [Google Scholar]
  12. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J, 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 : 2090–2093. [Google Scholar]
  13. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC, 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1 : 191–200. [Google Scholar]
  14. Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, van Olst JC, Shimizu C, Bulet P, Burns JC, 2002. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem 269 : 2232–2237. [Google Scholar]
  15. Aubouy A, Deloron P, Migot-Nabias F, 2002. Plasma and in vitro levels of cytokines during and after a Plasmodium falciparum malaria attack. Acta Trop 83 : 195–203. [Google Scholar]
  16. Kemna EHJM, Tjalsma H, Podust VN, Swinkels DW, 2007. Mass-spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 54 : 4. [Google Scholar]
  17. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W, 2004. Pro-hepcidin: expression and cell specific localization in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 53 : 735–743. [Google Scholar]
  18. Brookes MJ, Sharma NK, Tselepsis C, Iqbal TH, 2005. Serum pro-hepcidin: measuring active hepcidin or a non-functional precursor? Gut 54 : 169–170. [Google Scholar]
  19. Luukonen S, Punnonen K, 2006. Serum pro-hepcidin concentrations and their responses to oral iron supplementation in healthy subjects manifest considerable inter-individual variation. Clin Chem Lab Med 44 : 1361–1362. [Google Scholar]
  20. Oguz A, Uzunlulu M, Hekim N, 2006. Hepcidin is not a marker of chronic inflammation in atherosclerosis. Anadolu Kardiyol Derg 6 : 239–242. [Google Scholar]
  21. Sari M, de Pee S, Martini E, Herman S, Sugiatmi, Bloem MW, Yip R, 2001. Estimating the prevalence of anaemia: a comparison of three methods. Bull World Health Organ 79 : 506–511. [Google Scholar]
  22. Prakash S, Kapil U, Singh G, Dwivedi SN, Tandon M, 1999. Utility of HemoCue in estimation of hemoglobin against standard blood cell counter method. J Assoc Physicians India 47 : 995–997. [Google Scholar]
  23. Bhaskaram P, Balakrishna N, Radhakrishna KV, Krishnaswamy K, 2003. Validation of hemoglobin estimation using Hemocue. Indian J Pediatr 7 : 25–28. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.77.623
Loading
/content/journals/10.4269/ajtmh.2007.77.623
Loading

Data & Media loading...

  • Received : 23 Feb 2007
  • Accepted : 05 Jul 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error