Volume 77, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


In view of the changing policy towards artemisinin-based combination therapies (ACTs), the efficacy, tolerance, and degree of re-infection of two ACTs were investigated: artesunate plus sulfadoxine/pyrimethamine (As + SP) and AS plus sulfamethoxypyrazine/pyrimethamine (As + SMP). One hundred three children were assigned to receive As + SP and 109 to receive As + SMP. In spite of the high incidence of resistance to SP, As + SP showed satisfactory results consistent with recent recommendations for ACTs (adequate clinical and parasitologic response on day 28 [ACPR] ≥ 90%), but results with As + SMP fulfilled the most stringent criteria (ACPR ≥ 95%). The absence of side effects and the low price of these drugs make them it worth to reconsider national therapies in favor of either of these two drug combinations.


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  • Received : 23 Aug 2006
  • Accepted : 24 Jun 2007

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