1921
Volume 77, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Cryptosporidiosis is an important cause of diarrhea worldwide. In normal hosts, infection is self-limited and associated with seroconversion and partial immunity to reinfection. Immunity is associated with interferon gamma (IFNγ) production. surface proteins gp15 and gp40 are among the immunodominant proteins in terms of antibody responses. We asked the question of whether these antigens also stimulate production of IFNγ in patients who have serologic evidence of prior infection. Whole blood from seropositive donors was stimulated with recombinant gp15 and gp 40 from and or His-tag controls. gp15 stimulated increased production of IFNγ. By contrast, there was no significant increase after stimulation with gp15 or either gp40 preparation. IFNγ production in response to gp15 was noted in both CD4 and CD8 cells. This highlights the potential for gp15 as a vaccine candidate for human cryptosporidiosis.

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2007-09-01
2017-11-19
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References

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  • Received : 01 Mar 2007
  • Accepted : 18 May 2007

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