1921
Volume 77, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Visceral leishmaniasis (VL), which is caused by the protozoa and transmitted by the bite of the female sand fly , is common in Bihar, India. Wilson disease is an autosomal recessive disorder of copper metabolism in which copper is deposited in the brain and liver. We report a case of an extremely uncommon combination of these diseases in a patient. Treatment options for such a combination of diseases are limited and difficult.

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/content/journals/10.4269/ajtmh.2007.77.560
2007-09-01
2017-09-19
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References

  1. Desjeux P, 2000. Leishmania/HIV Co-infection in South-Western Europe, 1990–1998, Retrospective Analysis of 965 Cases. Geneva: World Health Organization.
  2. Annon, 2000. The Leishmaniasis and Leishmania/HIV Co-Infections. Fact Sheet No. 116. Geneva: World Health Organization.
  3. Davies CR, Kaye P, Croft SL, Sundar S, 2003. Leishmaniasis: new approaches to disease control. BMJ 326 : 377–382.
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  5. Mak CM, Tam S, Fan ST, Lie CL, Lam CW, 2006. Wilson disease: a patient undiagnosed for 18 years. Hong Kong Med J 12 : 154–158.
  6. Chan P, Yang J, 2005. Gene symbol: ATP7B disease: Wilson disease. Hum Genet 118 : 548.
  7. Gupta A, Aikath D, Neyogi R, Datta S, Basu K, Maity B, Trivedi R, Ray J, Das SK, Gangopadhyay PK, Ray K, 2005. Molecular pathogenesis of Wilson disease: haplotype analysis, detection of prevalent mutations and genotype-phenotype correlation in Indian patients. Hum Genet 118 : 49–57.
  8. Bhattacharya SK, Jha TK, Sundar S, Thakur CP, Engel J, Sindermann H, Junge K, Karbwang J, Bryceson AD, Berman JD, 2004. Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India. Clin Infect Dis 138 : 217–221.
  9. Hoogenraad TU, 2006. Paradigm shift in treatment of Wilson disease: zinc therapy now treatment of choice. Brain Dev 28 : 141–146.
  10. Brewer GJ, 2006. Novel therapeutic approaches to the treatment of Wilson disease. Expert Opin Pharmacother 7 : 317–324.
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  • Received : 06 Dec 2006
  • Accepted : 24 Apr 2007

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