1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 77, Issue 3
  4. Article
Volume 77, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

This study was conducted in Posse, a rural community in Goiàs, Brazil. Persons were recruited into the study through house-to-house sampling of all houses in the sampled area. Blood samples were collected for seropositivity assessments for and an electrocardiogram was assessed using a portable system. The results demonstrate significant differences between seropositive and seronegative persons for electrocardiographic (ECG)–derived traits. Seropositive persons had substantially longer QRS and QT intervals than seronegative persons. The PR interval was significantly different between seropositive and seronegative persons. Conduction abnormalities were observed more frequently in seropositive than seronegative persons. Right bundle branch block, an ECG abnormality typical of Chagas disease, was observed in 15% of seropositive persons compared with less than 1% of seronegative persons. Results indicate that infection and subsequent Chagas disease will continue to be major health problems for the foreseeable future in this typical rural area of Brazil.

Copyright 2007 The American Society of Tropical Medicine
Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2007.77.495
2007-09-01
2019-06-16

  • From This Site

    /content/journals/10.4269/ajtmh.2007.77.495
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/77/3/0770495.html?itemId=/content/journals/10.4269/ajtmh.2007.77.495&mimeType=html&fmt=ahah

References

  1. Dias JC, Silveira AC, Schofield CJ, 2002. Impact of Chagas disease control in Latin America: a review. Mem Inst Oswaldo Cruz 97 : 603–612. [Google Scholar]
  2. World Health Organization, 2002. Control of Chagas disease. World Health Organ Tech Rep Ser 905 : 1–109. [Google Scholar]
  3. Moncayo A, 2003. Chagas disease: current epidemiological trends after the interruption of vectoral and transfusional transmission in the Southern Cone countries. Mem Inst Oswaldo Cruz 98 : 577–591. [Google Scholar]
  4. Dutra WO, Rocha MO, Teixeira MM, 2005. The clinical immunology of human Chagas disease. Trends Parasitol 21 : 581–587. [Google Scholar]
  5. Kirchhoff LV, 1999. American trypanosomiasis (Chagas disease). Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. New York: Churchill Livingstone, 785–796.
  6. Coll-Cardenas R, Espinoza-Gomez F, Maldonado-Rodriguez A, Reyes-Lopez PA, Huerta-Viera M, Rojas-Larios F, 2004. Active transmission of human Chagas disease in Colima, Mexico. Mem Inst Oswaldo Cruz 99 : 363–368. [Google Scholar]
  7. Rizzo NR, Arana BA, Diaz A, Cordon-Rosales C, Klein RE, Powell MR, 2003. Seroprevalence of Trypanosoma cruzi infection among school-age children in the endemic area of Guatemala. Am J Trop Med Hyg 68 : 678–682. [Google Scholar]
  8. Grijalva MJ, Escalante L, Paarades RA, Costales JA, Padilla A, Rowland EC, Aguilar JM, Racines J, 2003. Seroprevalence and risk factors for Trypanosoma cruzi infection in the Amazon region of Ecuador. Am J Trop Med Hyg 69 : 380–385. [Google Scholar]
  9. Pinto AY, Valente SA, Valente VC, 2004. Emerging acute Chagas disease in Amazonian Brazil: case reports with serious cardiac involvement. Braz J Infect Dis 8 : 454–460. [Google Scholar]
  10. Gurtler RE, Cecere MC, Lauricella MA, Petersen RM, Chuit R, Segura EL, Cohen JE, 2005. Incidence of Trypanosoma cruzi infection among children following domestic reinfestation after insecticide spraying in rural northwestern Argentina. Am J Trop Med Hyg 73 : 95–103. [Google Scholar]
  11. Borges JS, Machada de Assis GF, Gomes LV, Dias JC, Pinto ID, Martins-Filho OA, Torres RM, Vinas PA, Bahia MT, Machado-Coelho GL, Lana M, 2006. Seroprevalence of Chagas disease in school children from two municipalities of Jequitinhonha Valley, Minas Gerais, Brazil: six years following the onset of epidemiological surveillance. Rev Inst Med Trop Sao Paulo 48 : 81–86. [Google Scholar]
  12. Garg N, Bhatia V, 2005. Current status and future prospects for a vaccine against American trypanosomiasis. Expert Rev Vaccines 4 : 867–880. [Google Scholar]
  13. Urbino JA, Docompo R, 2004. Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol 19 : 495–501. [Google Scholar]
  14. Kirchhoff LV, 2003. Changing epidemiology and approaches to therapy for Chagas disease. Curr Infect Dis Rep 5 : 59–65. [Google Scholar]
  15. McCarthy M, 2003. American Red Cross to screen blood for Chagas disease. Lancet 362 : 1988. [Google Scholar]
  16. Busch MP, Kleinman SH, Nemo GJ, 2003. Current and emerging infectious risks of blood transfusions. JAMA 289 : 959–961. [Google Scholar]
  17. Beard CB, Pye G, Steurer FJ, Rodrigues R, Campman R, Peterson AT, Ramsey J, Wirtz RA, Robinson LE, 2003. Chagas disease in a domestic transmission cycle, southern Texas, USA. Emerg Infect Dis 9 : 103–105. [Google Scholar]
  18. DiPentima MC, Hwang LY, Skeeter CM, Edwards MS, 1999. Prevalence of antibody to Trypanosoma cruzi in pregnant Hispanic women in Houston. Clin Infect Dis 28 : 1281–1285. [Google Scholar]
  19. Leiby DA, Herron RM, Read EJ, Lenes BA, Stumpf RJ, 2002. Trypanosoma cruzi in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmission. Transfusion 42 : 549–555. [Google Scholar]
  20. Centers for Disease Control and Prevention, 2002. Chagas disease after organ transplantation—United States, 2001. MMWR Morb Mortal Wkly Rep 51 : 210–212. [Google Scholar]
  21. Kirchhoff LV, Weiss LM, Wittner M, Tanowitz HB, 2004. Parasitic diseases of the heart. Front Biosci 9 : 706–723. [Google Scholar]
  22. Prata A, 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1 : 92–100. [Google Scholar]
  23. Goldbaum M, Ajimura FY, Litvoc J, Alves de Carvalho S, Eluf-Neto J, 2004. American trypansomiasis and electrocardiographic alterations among industrial workers in Sao Paulo, Brazil. Rev Inst Med Trop Sao Paulo 46 : 299–302. [Google Scholar]
  24. Yacoub S, Birks EJ, Slavik Z, Henein M, 2003. Early detection of myocardial dysfunction in Chagas disease using novel echocardiographic indices. Trans R Soc Trop Med Hyg 97 : 528–534. [Google Scholar]
  25. Sosa-Hurado F, Mazariego-Aranda M, Hernandez-Becerril N, Garza-Murillo V, Cardenas M, Reyes PA, Hirayama K, Monteon VM, 2003. Electrocardiographic findings in Mexican Chagasic subjects living in high and low endemic regions of Trypansoma cruzi infection. Mem Inst Oswaldo Cruz 98 : 605–610. [Google Scholar]
  26. Rangel-Flores H, Sánchez B, Mendoza-Duarte J, Barbnabe C, Breniere FS, Ramos C, Espinoza B, 2001. Serologic and parasitologic demonstration of Trypansoma cruzi infections in an urban area of central Mexico: correlation with electrocardiographic alterations. Am J Trop Med Hyg 65 : 887–895. [Google Scholar]
  27. Jorge MT, Macedo TA, Janones RS, Carizzi DP, Heredia RA, Acha RE, 2003. Types of arrhythmia among cases of American trypanosomiasis compared with those in other cardiology patients. Ann Trop Med Parasitol 97 : 139–148. [Google Scholar]
  28. Maguire JH, Hoff R, Sherlock I, Guimaraes AC, Sleigh AC, Ramos NB, Mott KE, Weller TH, 1987. Cardiac morbidity and mortality due to Chagas disease: prospective electrocardiographic study of a Brazilian community. Circulation 75 : 1140–1145. [Google Scholar]
  29. Salles G, Xavier S, Sousa A, Hasslocher-Moreno A, Cardosa C, 2003. Prognostic value of QT interval parameters for mortality risk stratification in Chagas disease: results of a long-term follow-up study. Circulation 108 : 305–312. [Google Scholar]
  30. Salles G, Xavier S, Sousa A, Hasslocher-Moreno A, Cardosa C, 2004. T-wave axis deviation as an independent predictor of mortality in chronic Chagas disease. Am J Cardiol 93 : 1136–1140. [Google Scholar]
  31. Almasy L, Blangero J, 1998. Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet 62 : 1198–1211. [Google Scholar]
  32. Brutus L, Schneider D, Postigo J, Delgado W, Mollinedo S, Chippaux JP, 2007. Evidence of congenital transmission of Trypanosoma cruzi in a vector-free area of Bolivia. Trans R Soc Trop Med Hyg: (Epub ahead of print).
  33. Corbucci HA, Haber DM, Bestetti RB, Cordeiro JA, Fioroni ML, 2006. QT interval dispersion in patients with chronic heart failure secondary to Chagas cardiomyopathy: correlation with clinical variables of prognostic significance. Cardiovasc Pathol 15 : 18–23. [Google Scholar]
  34. Soto-Rojas G, Cortes JM, Medrano GA, 1984. Electrocardiographic changes in 29 apparently healthy subjects with positive serological tests for Chagas disease. Arch Inst Cardiol Mex 54 : 579–583. [Google Scholar]
  35. Pimenta J, Miranda M, Pereira CB, 1983. Electrophysiologic findings in long-term asymptomatic chagasic individuals. Am Heart J 106 : 374–380. [Google Scholar]
  36. DeBacquer D, DeBacker G, Kornitzer M, 2000. Prevalences of ECG findings in large population based samples of men and women. Heart 84 : 625–633. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.77.495
Loading
Electrocardiographic Characteristics in a Population with High Rates of Seropositivity for Trypanosoma cruzi Infection
The American Journal of Tropical Medicine and Hygiene 77, 495 (2007); https://doi.org/10.4269/ajtmh.2007.77.495
/content/journals/10.4269/ajtmh.2007.77.495
/content/journals/10.4269/ajtmh.2007.77.495
Loading

Data & Media loading...

  • Received : 11 Feb 2007
  • Accepted : 27 May 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error