1921
Volume 77, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A total of 248 isolates were sampled in travelers with malaria who came to Marseille, France from Comoros to investigate activities of antimalarial drugs and molecular markers of drug resistance. Of the 248 isolates, 126 were maintained in culture. Of these, 53% were resistant to chloroquine, and 3% had reduced susceptibility to quinine, mefloquine, and atovaquone; 1% had reduced susceptibility to halofantrine and dihydroartemisinin; 7% had reduced susceptibility to monodesethylamodiaquine; 37% had reduced susceptibility to cycloguanil; and none had reduced susceptibility to lumefantrine. Resistance-associated point mutations were screened in 207 isolates. No mutations in the cytochrome b gene were found. Of the 207 isolates, 119 (58%) had a mutation in the dihydrofolate reductase () gene at codon 108, 6 (5%) had mutations in both codon 108 and the dihydropteroate synthase codon 437, and 115 (56%) had the chloroquine resistance–associated K76T mutation in the chloroquine resistance transporter gene. This study represents a unique opportunity to improve surveillance of drug resistance in Comoros with consequences for treatment and chemoprophylaxis guidelines.

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  • Received : 15 Mar 2007
  • Accepted : 13 Jun 2007

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