1921
Volume 77, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

During routine antimalarial drug efficacy trials, we observed, for the first time, severe thrombocytopenia developing in monkeys infected with . Data obtained from 26 infected with the AMRU-1 strain showed that 77% developed severe thrombocytopenia, whereas only 15% had severe anemia, with hemorrhagic diathesis ensuing in 31%. In general, thrombocytopenic monkeys either failed primary treatment with experimental antimalarial drugs or were found to have higher-density parasitemias, longer patency duration, and lower hematocrits. In these monkeys, severe thrombocytopenia inversely correlated to parasitemia ( = −1.0), and animals that received a blood transfusion had significantly higher platelet counts ( < 0.05) by day 38 after inoculation. In conclusion, the AMRU-1 strain of , was considered to be highly pathogenic to monkeys, and thrombocytopenia rather than anemia should be regarded an early indicator of drug treatment failure with this strain.

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  • Received : 22 Dec 2005
  • Accepted : 20 Mar 2007

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