Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


This report describes a 32-year-old male AIDS patient. He presented with a clinical picture characterized by severe headache, blurred vision, and fever that had lasted for 10 days. At admission, no remarkable neurologic abnormalities were observed. Cranial tomography showed a ring-enhanced lesion with edema and a mass effect in the right occipital lobe. The initial diagnosis was toxoplasmosis, and treatment of this was administered. However, 5 days later, the patient’s clinical status worsened and he died. The necropsy showed necrotizing and hemorrhagic encephalitis, with trophozoites similar to an amoeba species. Furthermore, the kidneys, adrenal glands, thyroid gland, and liver were also involved. The amoeba was identified by an immunofluorescence test.


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  1. Martinez AJ, Visvesvara GS, 1997. Free-living, amphizoic and opportunistic amebas. Brain Pathol 7 : 583–598. [Google Scholar]
  2. Schuster FL, Visvesvara GS, 2004. Free-living amoebae as opportunistic and nonopportunistic pathogens of humans and animals. Int J Parasitol 34 : 1001–1027. [Google Scholar]
  3. Schuster FL, Visvesvara GS, 2004. Amebae and ciliated protozoa as causal agents of waterborne zoonotic disease. Vet Parasitol 126 : 91–120. [Google Scholar]
  4. Dunnebacke T, Schuster F, Yagi S, Booton G, 2004. Balamuthia mandrillaris from soil samples. Microbiology 150 : 2837–2842. [Google Scholar]
  5. Kiderlen AF, Laube U, 2004. Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway. Parasitol Res 94 : 49–52. [Google Scholar]
  6. Tavares M, Correia da Costa JM, Carpenter RR, Santos LA, Afonso C, Aguiar A, Pereira J, Cardoso AI, Schuster FL, Yagi S, Sriram R, Visvesvara GS, 2006. Diagnosis of first case of Balamuthia amoebic enceplalitis in Portugal by immunofluorescence and PCR. J Clin Microb 44 : 2660–2663. [Google Scholar]
  7. Schuster FL, Honarmand S, Visvesvara GS, Glaser CA, 2006. Detection of antibodies against free-living amoeba Balamuthia mandrillaris and Acanthamoeba species in a population of patients with encephalitis. Clin Infect Dis 42 : 1260–1265. [Google Scholar]
  8. Yagi S, Booton GC, Visvesvara GS, Schuster FL, 2005. Detection of Balamuthia mitochondrial 16S rRNA DNA in clinical specimens by PCR. J Clin Microbiol 43 : 3192–3197. [Google Scholar]
  9. Jung S, Schelper RL, Visvesvara GS, Chang HT, 2004. Balamuthia mandrillaris meningoencephalitis in an immunocompetent patient: an unusual clinical course and a favorable outcome. Arch Pathol Lab Med 128 : 466–468. [Google Scholar]
  10. Deetz TR, Sawyer MH, Billman G, Schuster FL, Visvesvara GS, 2003. Successful treatment of balamuthia amoebic encephalitis: presentation of 2 cases. Clin Infect Dis 37 : 1304–1312. [Google Scholar]
  11. Pritzker A, Kim B, Agrawal D, Southern P, Pandya A, 2004. Fatal granulomatous amebic encephalitis caused by Balamuthia mandrillaris presenting as skin lesion. J Am Acad Dermatol 50 : 38–41. [Google Scholar]
  12. Schuster FL, Visvesvara GS, 2004. Opportunistic amoebae: challenges in prophylaxis and treatment. Drug Resist Update 7 : 41–51. [Google Scholar]
  13. Anzil AP, Rao C, Wrzolek MA, Visvesvara GS, Sher JH, Kozlowski PB, 1991. Amebic meningoencephalitis in a patient with AIDS caused by a newly recognized opportunistic pathogen. Arch Pathol Lab Med 115 : 21–25. [Google Scholar]
  14. Chimelli L, Hahn MD, Scaravilli F, Wallace S, Visvesvara GS, 1992. Granulomatous amoebic encephalitis due to leptocytic amoebae: report of the first Brazilian case. Trans R Soc Trop Med Hyg 86 : 635. [Google Scholar]
  15. Haverkos HW, Remington JS, Chan JC, 1987. Assesment of Toxoplasma encephalitis (TE) therapy: a cooperative study. Am J Med 82 : 907–914. [Google Scholar]

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  • Received : 23 Apr 2007
  • Accepted : 27 Aug 2007

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