1921
Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The pathologic manifestations of infection depend on the interplay between the host and the parasite. A genetic single nucleotide polymorphism in the FcγRIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. This study investigated the relationship between this polymorphism and disease outcome. FcγRIIa genotyping was performed on clinically characterized onchocerciasis patients ( = 100) and healthy controls ( = 74). FcγRIIa genotype R/R131 frequencies were significantly higher among patients with severe dermatopathology ( < 0.001). Increased risk of developing this form was mostly associated with one tribe (Masalit) (OR = 3.2, 95% CI 1–9.9, = 0.042). The H131 allele was found to be significantly associated with a reduced risk of having the severe form of the disease (adjusted OR = 0.26, 95% CI = 0.13–0.46, < 0.001). Our findings suggest that the polymorphism influences the clinical outcome of onchocerciasis.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2007.77.1074
2007-12-01
2017-09-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/77/6/0771074.html?itemId=/content/journals/10.4269/ajtmh.2007.77.1074&mimeType=html&fmt=ahah

References

  1. WHO, 2000. Onchocerciasis (River Blindness). The World Health Organization, Geneva, Fact sheet No: 95.
  2. WHO, 1995. Onchocerciasis and its control. Report of a WHO Expert Committee on Onchocerciasis Control. World Health Organ Tech Rep Ser 852 : 1– 104.
  3. Ali MM, Baraka OZ, AbdelRahman SI, Sulaiman SM, Williams JF, Homeida MM, Mackenzie CD, 2003. Immune responses directed against microfilariae correlate with severity of clinical onchodermatitis and treatment history. J Infect Dis 187 : 714–717.
  4. Gallin MY, Jacobi AB, Buttner DW, Schonberger O, Marti T, Erttmann KD, 1995. Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda). J Exp Med 182 : 41– 47.
  5. Mackenzie CD, Williams JF, Sisley BM, Steward MW, O’Day J, 1985. Variations in host responses and the pathogenesis of human onchocerciasis. Rev Infect Dis 7 : 802– 808.
  6. Murdoch ME, Payton A, Abiose A, Thomson W, Panicker VK, Dyer PA, Jones BR, Maizels RM, Ollier WE, 1997. HLA-DQ alleles associate with cutaneous features of onchocerciasis. The Kaduna-London-Manchester Collaboration for Research on Onchocerciasis. Hum Immunol 55 : 46– 52.
  7. Ottesen EA, 1995. Immune responsiveness and the pathogenesis of human onchocerciasis. J Infect Dis 171 : 659– 671.
  8. Hall LR, Lass JH, Diaconu E, Strine ER, Pearlman E, 1999. An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis. J Immunol 163 : 4970– 4975.
  9. Hall LR, Diaconu E, Pearlman E, 2001. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J Immunol 167 : 919– 925.
  10. Ravetch JV, Bolland S, 2001. IgG Fc receptors. Annu Rev Immunol 19 : 275– 290.
  11. Marzocchi-Machado CM, Alves CM, Azzolini AE, Polizello AC, Carvalho IF, Lucisano-Valim YM, 2002. Fcgamma and complement receptors: expression, role and co-operation in mediating the oxidative burst and degranulation of neutrophils of Brazilian systemic lupus erythematosus patients. Lupus 11 : 240– 248.
  12. Sisley BM, Mackenzie CD, Steward MW, Williams JF, O’Day J, Luty AJ, Braga M, el Sheikh H, 1987. Associations between clinical disease, circulating antibodies and C1q-binding immune complexes in human onchocerciasis. Parasite Immunol 9 : 447– 463.
  13. van Sorge NM, van der Pol WL, van de Winkel JG, 2003. FcgammaR polymorphisms: implications for function, disease susceptibility and immunotherapy. Tissue Antigens 61 : 189–202.
  14. Bharadwaj D, Stein MP, Volzer M, Mold C, Du Clos TW, 1999. The major receptor for C-reactive protein on leukocytes is fcgamma receptor II. J Exp Med 190 : 585– 590.
  15. Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ, 1991. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147 : 1338–1343.
  16. Tax WJ, Frenken LA, Glaudemans CA, Tamboer WP, Koene RA, 1995. Polymorphism of Fc receptor (Fc gamma RII) is reflected in cytokine release and adverse effects of mIgG1 anti-CD3/TCR antibody during rejection treatment after renal transplantation. Transplant Proc 27 : 867– 868.
  17. Ghalib HW, MacKenzie CD, Kron MA, Williams JF, el Khalifa M, el Sheikh H, 1987. Severe onchocercal dermatitis in the Ethiopian border region of Sudan. Ann Trop Med Parasitol 81 : 405– 419.
  18. Mackenzie CD, Williams JF, Guderian RH, O’Day J, 1987. Clinical responses in human onchocerciasis: parasitological and immunological implications. Ciba Found Symp 127 : 46– 72.
  19. Murdoch ME, Hay RJ, Mackenzie CD, Williams JF, Ghalib HW, Cousens S, Abiose A, Jones BR, 1993. A clinical classification and grading system of the cutaneous changes in onchocerciasis. Br J Dermatol 129 : 260– 269.
  20. Jiang XM, Arepally G, Poncz M, McKenzie SE, 1996. Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). J Immunol Methods 199 : 55– 59.
  21. Rascu A, Repp R, Westerdaal NA, Kalden JR, van de Winkel JG, 1997. Clinical relevance of Fc gamma receptor polymorphisms. Ann N Y Acad Sci 815 : 282– 295.
  22. Bandi C, Trees AJ, Brattig NW, 2001. Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases. Vet Parasitol 98 : 215–238.
  23. Brattig NW, 2004. Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria. Microbes Infect 6 : 113– 128.
  24. Shi YP, Nahlen BL, Kariuki S, Urdahl KB, McElroy PD, Roberts JM, Lal AA, 2001. Feγ receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis 184 : 107– 111.
  25. Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP, 1996. Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest 97 : 1348–1354.
  26. Bliss SK, Butcher BA, Denkers EY, 2000. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol 165 : 4515–4521.
  27. Karassa FB, Trikalinos TA, Ioannidis JP, 2004. The role of FcgammaRIIA and IIIA polymorphisms in autoimmune diseases. Biomed Pharmacother 58 : 286– 291.
  28. Doetze A, Satoguina J, Burchard G, Rau T, Loliger C, Fleischer B, Hoerauf A, 2000. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. Int Immunol 12 : 623– 630.
  29. Dafa’Alla TH, Ghalib HW, Abdelmageed A, Williams JF, 1992. The profile of IgG and IgG subclasses of onchocerciasis patients. Clin Exp Immunol 88 : 258– 263.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.77.1074
Loading
/content/journals/10.4269/ajtmh.2007.77.1074
Loading

Data & Media loading...

  • Received : 13 Mar 2007
  • Accepted : 02 Jul 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error