1921
Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We report the results of clinical studies carried out at six sites in Madagascar, between January and October 2006. The aims were (i) to update our knowledge of the burden of infection and (ii) to assess the therapeutic efficacy of chloroquine for uncomplicated quartan malaria. Our findings confirm that is the third leading cause of malaria, accounting for 1.1% of all malarial infections. They also demonstrate that chloroquine—currently recommended for the home management of presumed malaria in children under the age of five years and commonly used by adults—remains highly effective in patients with uncomplicated infection.

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2007-12-01
2017-09-22
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References

  1. Greenwood BM, Bradley AK, Greenwood AM, Byass P, Jammeh K, Marsh K, Tulloch S, Oldfield FS, Hayes R, 1987. Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. Trans R Soc Trop Med Hyg 81 : 478–486.
  2. Molineaux L, Storey J, Cohen JE, Thomas A, 1980. A longitudinal study of human malaria in the West African Savanna in the absence of control measures: relationships between different Plasmodium species, in particular P. falciparum and P. malariae. Am J Trop Med Hyg 29 : 725–737.
  3. Smith T, Charlwood JD, Kihonda J, Mwankusye S, Billingsley P, Meuwissen J, Lyimo E, Takken W, Teuscher T, Tanner M, 1993. Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop 54 : 55–72.
  4. Trape JF, Rogier C, Konate L, Diagne N, Bouganali H, Canque B, Legros F, Badji A, Ndiaye G, Ndiaye P, Brahimi K, Faye O, Druilhe P, Pereira Da Silva L, 1994. The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal. Am J Trop Med Hyg 51 : 123–137.
  5. Breman JG, Egan A, Keusch GT, 2001. The intolerable burden of malaria: a new look at the numbers. Am J Trop Med Hyg 64 : iv–vii.
  6. Greenwood B, Marsh K, Snow R, 1991. Why do some African children develop severe malaria? Parasitol Today 7 : 277–281.
  7. Kawamoto F, Liu Q, Ferreira MU, Tantular IS, 1999. How prevalent are Plasmodium ovale and P. malariae in East Asia? Parasitol Today 15 : 422–426.
  8. Zhou M, Liu Q, Wongsrichanalai C, Suwonkerd W, Panart K, Prajakwong S, Pensiri A, Kimura M, Matsuoka H, Ferreira MU, Isomura S, Kawamoto F, 1998. High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR-based diagnoses. Trop Med Int Health 3 : 304–312.
  9. Werndorfer WH, MacGregor I, 1998. Malaria: Principles and Practice of Malariology. London: Churchill Livingstone.
  10. Abdurrahman MB, Aikhionbare HA, Babaoye FA, Sathiakumar N, Narayana PT, 1990. Clinicopathological features of childhood nephrotic syndrome in northern Nigeria. Q J Med 75 : 563–576.
  11. Kibukamusoke JW, 1986. The hazard of malarial nephropathy. Parasitol Today 2 : 119–121.
  12. Otieno LS, Mc’Ligeyo SO, 1988. Review article: immune nephritides due to malaria. East Afr Med J 65 : 402–406.
  13. Institut National de la Statistique de Madagascar, 2002. Enquête Auprès des Ménages. Antananarivo: Institut National de la Statistique de Madagascar, 71–83.
  14. Jeremiah M, Sulhuan A, 2004. Mortalité des enfants de moins de 5 ans à Madagascar. Enquête Démographique et de la Santé III à Madagascar 2004 : 191–201.
  15. UNICEF. Multiple Indicator Cluster Survey (MICS), 2000. Available at: http://www.childinfo.org/MICS2/newreports/madagascar/madagascar.pdf.
  16. Collins WE, Jeffery GM, 2002. Extended clearance time after treatment of infections with Plasmodium malariae may not be indicative of resistance to chloroquine. Am J Trop Med Hyg 67 : 406–410.
  17. Maguire JD, Sumawinata IW, Masbar S, Laksana B, Prodjodipuro P, Susanti I, Sismadi P, Mahmud N, Bangs MJ, Baird JK, 2002. Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet 360 : 58–60.
  18. World Health Organization, 2001. Monitoring Antimalarial Drug Resistance. Report of a WHO consultation (WHO/CDS/CSR/ EPH/2002.17; WHO/CDS/RBM/2002.39). December 3–5, 2001; Geneva, Switzerland.
  19. de Monbrison F, Angei C, Staal A, Kaiser K, Picot S, 2003. Simultaneous identification of the four human Plasmodium species and quantification of Plasmodium DNA load in human blood by real-time polymerase chain reaction. Trans R Soc Trop Med Hyg 97 : 387–390.
  20. Robert V, Le Goff G, Andrianaivolambo L, Randimby FM, Domarle O, Randrianarivelojosia M, Raharimanga V, Raveloson A, Ravaonjanahary C, Ariey F, 2006. Moderate transmission but high prevalence of malaria in Madagascar. Int J Parasitol 36 : 1273–1281.
  21. Ratsimbasoa A, Randriamanantena A, Raherinjafy R, Rasoarilalao N, Menard D, 2007. Which malaria rapid test for Madagascar? Field and laboratory evaluation of three tests and expert microscopy of samples from suspected malaria patients in Madagascar. Am J Trop Med Hyg 76 : 481–485.
  22. Lepers JP, Fontenille D, Rason MD, Raharimalala L, Coulanges P, 1990. Malaria in 1989 in a village in the Highland Plateaux of Madagascar. Parasitologic and clinical data obtained in a longitudinal study of a population representative of this region. Arch Inst Pasteur Madagascar 57 : 11–52.
  23. Lepers JP, Rason MD, Raharimalala L, Rabarison P, Rene JP, Coulanges P, 1990. Malaria in the island of Sainte Marie in 1989. Epidemiologic, parasitologic, serologic and clinical data. Arch Inst Pasteur Madagascar 57 : 53–74.
  24. Menard D, Nina Harimanana Andrianina N, Ramiandrasoa Z, Randriamanantena A, Rasoarilalao N, Jahevitra M, Tuseo L, Raveloson A, 2007. Randomized clinical trial to assess artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar. Malar J 6 : 65.
  25. Service de Lutte contre le Paludisme, 2005. Politique Nationale de Lutte contre le Paludisme. Ministère de la Santé et du Planning Familial: Antananarivo, Madagascar.
  26. Ratsimbasoa A, Randrianarivelojosia M, Millet P, Soares JL, Rabarijaona L, Rakotoson B, Malvy D, Menard D, 2006. Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy children. Malar J 5 : 79.
  27. Tangpukdee N, Thanachartwet V, Krudsood S, Luplertlop N, Pornpininworakij K, Chalermrut K, Phokham S, Kano S, Looareesuwan S, Wilairatana P, 2006. Minor liver profile dysfunctions in Plasmodium vivax, P. malaria and P. ovale patients and normalization after treatment. Korean J Parasitol 44 : 295–302.
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  • Received : 30 Apr 2007
  • Accepted : 02 Jul 2007

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