1921
Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The potential role of polymorphisms in the and genes and susceptibility to amodiaquine and desethylamodiaquine were explored in 15 chloroquine-resistant Colombian isolates. Single nucleotide polymorphisms in the gene, including a newly reported mutation (), were seen in isolates with decreased susceptibility to amodiaquine and desethylamodiaquine. The lowest susceptibility found to amodiaquine was observed in an isolate carrying a and Dd2-like haplotype, whereas a haplotype related to the 7G8 Brazilian strain was found in a Colombian isolate with the lowest susceptibility to desethylamodiaquine. This exploratory study suggests that polymorphisms in the and genes play a role in amodiaquine and desethylamodiaquine resistance and warrants further study.

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2007-12-01
2017-11-22
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  • Received : 21 Mar 2007
  • Accepted : 05 Sep 2007

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