Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Three different drugs (mefloquine, atovaquone/proguanil, doxycycline) are recommended for malaria chemoprophylaxis, each with approximately the same efficacy but various adverse event profiles, regimens, and prices. We investigated which medication the travelers would have chosen on the basis of written evidence-based information and the impact that pretravel consultation had on their decision. A prospective study was performed in a travel clinic and private practice, and 1073 travelers were included; 45% chose mefloquine (Lariam or Mephaquine), 21% atovaquone/proguanil (Malarone), 18% doxycycline (Supracycline), 5% “no prophylaxis,” and 11% “do not know.” Lariam was principally chosen because of prior experience (38%), Mephaquine because of low price (34%), and doxycycline and Malarone because of the profile of adverse events (55% and 43%, respectively). Based on objective written information, travelers most frequently chose mefloquine for chemoprophylaxis. This suggests that evidence-based information weighs more heavily than negative publicity. Taking into account the perspective of the user should improve appropriateness of the pretravel advice.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Schlagenhauf P, Tschopp A, Johnson R, Nothdurft HD, Beck B, Schwartz E, Herold M, Krebs B, Veit O, Allwinn R, Steffen R, 2003. Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. BMJ 327 : 1078. [Google Scholar]
  2. Petersen E, Ronne T, Ronn A, Bygbjerg I, Larsen SO, 2000. Reported side effects to chloroquine, chloroquine plus proguanil, and mefloquine as chemoprophylaxis against malaria in Danish travelers. J Travel Med 7 : 79–84. [Google Scholar]
  3. Lobel HO, Baker MA, Gras FA, Stennies GM, Meerburg P, Hiemstra E, Parise M, Odero M, Waiyaki P, 2001. Use of malaria prevention measures by North American and European travelers to East Africa. J Travel Med 8 : 167–172. [Google Scholar]
  4. Chatterjee S, 1999. Compliance of malaria chemoprophylaxis among travelers to India. J Travel Med 6 : 7–11. [Google Scholar]
  5. Behrens RH, Taylor RB, Pryce DI, Low AS, 1998. Chemoprophylaxis compliance in travelers with malaria. J Travel Med 5 : 92–94. [Google Scholar]
  6. Cobelens FG, Leentvaar-Kuijpers A, 1997. Compliance with malaria chemoprophylaxis and preventative measures against mosquito bites among Dutch travellers. Trop Med Int Health 2 : 705–713. [Google Scholar]
  7. Landry PID, Darioli R, Burnier M, Genton B, 2006. Do travelers really take their mefloquine prophylaxis? Estimation of adherence by an electronic pill box. J Travel Med 13 : 8–14. [Google Scholar]
  8. Croft AM, Garner P, 2000. Mefloquine for preventing malaria in non-immune adult travellers. Cochrane Database Syst Rev 4 : CD000138. [Google Scholar]
  9. Carme B, Peguet C, Nevez G, 1997. Compliance with and tolerance of mefloquine and chloroquine + proguanil malaria chemoprophylaxis in French short-term travellers to sub-Saharan Africa. Trop Med Int Health 2 : 953–956. [Google Scholar]
  10. Wolters BA, Bosje T, Luinstra-Passchier MJ, 1997. [Not more symptoms with mefloquine use than with other drugs in malaria prophylaxis]. Ned Tijdschr Geneeskd 141 : 331–334 [article in Dutch]. [Google Scholar]
  11. Dupouy-Camet J, Yera H, Tourte-Schaeffer C, 2003. Problems in prescribing malaria chemoprophylaxis for travelers. Fundam Clin Pharmacol 17 : 161–169. [Google Scholar]
  12. Hoebe C, de Munter J, Thijs C, 1997. Adverse effects and compliance with mefloquine or proguanil antimalarial chemoprophylaxis. Eur J Clin Pharmacol 52 : 269–275. [Google Scholar]

Data & Media loading...

  • Received : 06 Mar 2007
  • Accepted : 04 Aug 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error