1921
Volume 77, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Three different drugs (mefloquine, atovaquone/proguanil, doxycycline) are recommended for malaria chemoprophylaxis, each with approximately the same efficacy but various adverse event profiles, regimens, and prices. We investigated which medication the travelers would have chosen on the basis of written evidence-based information and the impact that pretravel consultation had on their decision. A prospective study was performed in a travel clinic and private practice, and 1073 travelers were included; 45% chose mefloquine (Lariam or Mephaquine), 21% atovaquone/proguanil (Malarone), 18% doxycycline (Supracycline), 5% “no prophylaxis,” and 11% “do not know.” Lariam was principally chosen because of prior experience (38%), Mephaquine because of low price (34%), and doxycycline and Malarone because of the profile of adverse events (55% and 43%, respectively). Based on objective written information, travelers most frequently chose mefloquine for chemoprophylaxis. This suggests that evidence-based information weighs more heavily than negative publicity. Taking into account the perspective of the user should improve appropriateness of the pretravel advice.

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2007-12-01
2017-11-20
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References

  1. Schlagenhauf P, Tschopp A, Johnson R, Nothdurft HD, Beck B, Schwartz E, Herold M, Krebs B, Veit O, Allwinn R, Steffen R, 2003. Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. BMJ 327 : 1078.
  2. Petersen E, Ronne T, Ronn A, Bygbjerg I, Larsen SO, 2000. Reported side effects to chloroquine, chloroquine plus proguanil, and mefloquine as chemoprophylaxis against malaria in Danish travelers. J Travel Med 7 : 79–84.
  3. Lobel HO, Baker MA, Gras FA, Stennies GM, Meerburg P, Hiemstra E, Parise M, Odero M, Waiyaki P, 2001. Use of malaria prevention measures by North American and European travelers to East Africa. J Travel Med 8 : 167–172.
  4. Chatterjee S, 1999. Compliance of malaria chemoprophylaxis among travelers to India. J Travel Med 6 : 7–11.
  5. Behrens RH, Taylor RB, Pryce DI, Low AS, 1998. Chemoprophylaxis compliance in travelers with malaria. J Travel Med 5 : 92–94.
  6. Cobelens FG, Leentvaar-Kuijpers A, 1997. Compliance with malaria chemoprophylaxis and preventative measures against mosquito bites among Dutch travellers. Trop Med Int Health 2 : 705–713.
  7. Landry PID, Darioli R, Burnier M, Genton B, 2006. Do travelers really take their mefloquine prophylaxis? Estimation of adherence by an electronic pill box. J Travel Med 13 : 8–14.
  8. Croft AM, Garner P, 2000. Mefloquine for preventing malaria in non-immune adult travellers. Cochrane Database Syst Rev 4 : CD000138.
  9. Carme B, Peguet C, Nevez G, 1997. Compliance with and tolerance of mefloquine and chloroquine + proguanil malaria chemoprophylaxis in French short-term travellers to sub-Saharan Africa. Trop Med Int Health 2 : 953–956.
  10. Wolters BA, Bosje T, Luinstra-Passchier MJ, 1997. [Not more symptoms with mefloquine use than with other drugs in malaria prophylaxis]. Ned Tijdschr Geneeskd 141 : 331–334 [article in Dutch].
  11. Dupouy-Camet J, Yera H, Tourte-Schaeffer C, 2003. Problems in prescribing malaria chemoprophylaxis for travelers. Fundam Clin Pharmacol 17 : 161–169.
  12. Hoebe C, de Munter J, Thijs C, 1997. Adverse effects and compliance with mefloquine or proguanil antimalarial chemoprophylaxis. Eur J Clin Pharmacol 52 : 269–275.
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  • Received : 06 Mar 2007
  • Accepted : 04 Aug 2007

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